Yaşa bağlı maküla dejenerasyonu hastalarında fotodinamik tedavi sonuçları

Purpose: To evaluate the efficacy of photodynamic therapy in patients who had choroidal neovascularization due to agerelated macular degeneration (AMD). Materials and Methods: Data on 30 eyes of 30 patients were evaluated. Sixteen patients were men and 14 were women. Mean age was 68.4;plusmn;8.74 (47 to 81 years) years. Mean follow-up time was 15.7;plusmn;3.28 months (10-22 months). The patients;amp;#8217; best corrected visual acuities were measured by Early Treatment of Diabetic Retinopathy Study (ETDRS) chart number 2 and lesion types and the GLD of the lesions were measured by Topcon Image Net Fundus Camera. The indication for photodynamic therapy was based on the European Ophthalmology Society;amp;#8217;s criteria published in 2001. The patients were invited to undergo control examinations 1 week and 3 months after the therapy and thereafter every 3 months. In each control examination the best corrected visual acuity was checked by ETDRS chart, fundus examinations were performed and fundus photographs were recorded by fundus camera, and FFA examinations was performed, especially in the first and second controls. Results: After 2;plusmn;1.44 therapies (ranging from 1 to 5) 22 patients (73.3%) could have been treated, but 8 patients (27.7%) had persistent CNVs. There was no significant difference in visual loss between the two groups but the loss in the successful group was 1.5 LogMAR standard lines less than that in the unsuccessful group.Amaç: Bu çalışmada fotodinamik tedavinin yaşa bağlı maküla dejenerasyonda gelişen koroidal neovaskülarizasyonların tedavisindeki etkinliği değerlendirildi. Gereç ve Yöntem: Çalışmaya 30 hastanın 30 gözü alındı. Hastaların 16’sı (%53.3) erkek, 14’ü (%47.7) kadındı. Hastaların yaş ortalaması 68.4±8.74 (47-81 yaş), ortalama takip süresi 15.7±3.28 ay (10-22 ay) idi. Tedavi öncesi hastaların en iyi düzeltilmiş görme keskinlikleri Early Treatment of Diabetic Retinopathy Study 2 numaralı eşeli ve lezyon tipleri ve lezyon büyüklükleri fundus kamera ile ölçüldü. Hastalara fotodinamik tedavi endikasyonu Avrupa Oftalmoloji Cemiyeti’nin 2001 yılında yayınladığı rehbere göre kondu. Hastalar FDT sonrası 1. hafta, 3. ay ve sonrasında her üç ayda bir kontrol edildi. Kontrollerde ETDRS eşeli ile en iyi düzeltilmiş görme keskinlikleri, fundus muayeneleri ve fundus kamera ile renkli fundus görüntüleri alındı ve özellikle ilk ve ikinci kontrollerde FFA’ları çekildi. Hastalar kontrollerinde FFA’daki florosein sızdırma özelliklerine göre dört gruba ayrıldılar ve sızıntının olmadığı durumlar ile sızıntının %50’den daha az hale geldiği durumlarda tedavi başarılı, sızıntının %50’den fazla olduğu durumlarda ise başarısız kabul edildi. Bulgular: Ortalama 2±1.44 (1-5) seanslık tedavi sonucunda 22 (%73.3) olguda KNV’nin gerilediği, 8 (%27.7) olguda ise KNV’nin devam ettiği tespit edildi. Başarılı grupla başarısız grup görme kaybı açısından değerlendirildiğinde başarılı grupta ortalama 1.5 LogMAR standart sırası daha az görme kaybı gelişti fakat aradaki fark istatistiksel olarak anlamlı değildi. (p=0.101). Tartışma: Sonuç olarak Verteporfin ile FDT ile Eksudatif tip YBMD tedavisinde etkili ve güvenli bir yöntemdir

Efficacy and Safety of Stereotactic Radiotherapy in Cushing's Disease: A Single Center Experience

Objective To determine the efficacy and safety of stereotactic RT in patients with Cushing's disease (CD)

Can "VAI" Better Indicate Metabolic Syndrome Compared with Other Metabolic Syndrome-Related Parameters in Patients with Thyroid Nodules? A Study from Turkey

Background: To investigate the relationship between visceral adiposity index (VAI) and other metabolic syndrome (MetS)-related parameters, and thyroid nodules

Sexual Functions of Transgender Individuals Before Gender Transition

Objective: It is important to evaluate sexual function during the follow-up of transgender individuals in the gender pre-transition period. However, there exists inadequate literature evaluating the sexual functions of transgender individuals who have not received hormone therapy and/or undergone gender-affirming surgery. The aim of this study was to evaluate sexual function in transgender individuals in the gender pre-transition period. Material and Methods: Transgender individuals who were admitted consecutively to the tertiary care hospital between February and December 2019 were evaluated. Those who agreed to fill the questionnaires were included. Sexual functions of participants were evaluated using the Golombok-Rust Inventory of Sexual Satisfaction developed for cisgender and heterosexual individuals. In addition, the Arizona Sexual Experiences Scale was used for a psychometric test. Results: Sixty-five participants who did not receive hormone therapy and/or undergone gender-affirming surgery were included. Of these, 45 individuals were trans men (TM), and 20 were trans women (TW). The mean ages of TW and TM were 25.05 +/- 6.73 and 24.23 +/- 5.58 years, respectively. The percentages of sexual dysfunction were found to be 87.8 degrees/o in TM and 92.3% in TW, according to the Arizona Sexual Experiences Scale. According to the common subscales of the Golombok-Rust Inventory of Sexual Satisfaction, the most common problem in both groups was low sexual frequency. Conclusion: Owing to the importance of evaluating the sexual function in transgender individuals during the gender pre-transition period or in those who do not intend to undergo gender-affirming treatment, a scale should be developed for this period

Effectiveness of Cabergoline Treatment in Patients with Acromegaly Uncontrolled with SSAs: Experience of a Single Tertiary Center

Purpose To evaluate the effectiveness of cabergoline and the parameters affecting cabergoline response as add-on treatment to somatostatin analaogues (SSA) in patients with acromegaly uncontrolled with SSAs