1 research outputs found
Single Site <i>N</i>‑Glycosylation of B Cell Maturation Antigen (BCMA) Inhibits γ‑Secretase-Mediated Shedding and Improves Surface Retention and Cell Survival
B cell maturation antigen (BCMA),
a member of the tumor
necrosis
factor receptor (TNFR) family, on the cell surface plays a key role
in maintaining the survival of plasma cells and malignant as well
as inflammatory accessory cells. Therefore, targeting BCMA or disrupting
its interaction with ligands has been a potential approach to cancer
therapy. BCMA contains a single N-glycosylation site,
but the function of N-glycan on BCMA is not understood.
Here, we found that the N-glycosylation of BCMA promoted
its cell-surface retention while removing the N-glycan
increased BCMA secretion through γ-secretase-mediated shedding.
Addition of γ-secretase inhibitor prevented nonglycosylated
BCMA from shedding and protected cells from dexamethasone and TRAIL-induced
apoptosis