Silver-based surface plasmon waveguide for terahertz quantum cascade lasers

Terahertz quantum cascade lasers (THz QCLs) have undergone rapid developments since their first demonstration in 2002. Presently, the wide spectral range (1.2–5.2 THz) and high output power (1 W) make THz QCLs promising sources for applications in high-resolution spectroscopy and THz imaging. However, their maximum operating temperature is only 199.5 K and therefore cryogenic cooling is still needed. Improving the thermal performance of THz QCLs is a key challenge for their practical usage. The waveguide loss is closely related with the device thermal performance. To lower the loss, copper has been used to replace the gold in the standard metal–metal waveguide scheme, and around 10 K increase in the maximum lasing temperature has been achieved. Here, we employ silver as the waveguide metal and investigate its effects on devices with a single surface-plasmon waveguide configuration

Effects of Huanglian-Jie-Du-Tang and its modified formula on the modulation of amyloid-β precursor protein processing in Alzheimer's disease models.

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Terahertz frequency quantum cascade lasers for use as waveguide-integrated local oscillators

Since their first demonstration in 2002, the performance of terahertz frequency quantum cascade lasers has developed extremely rapidly. We consider the potential use of terahertz frequency quantum cascade lasers as local oscillators in satellite-borne instrumentation for future Earth observation and planetary science missions. A specific focus will be on the development of compact, waveguide-integrated, heterodyne detection systems for the supra-terahertz range

Waveguide-integrated Terahertz Quantum Cascade Lasers for use as Local Oscillators

Terahertz-frequency quantum cascade lasers (THz QCLs) are compact sources of 1–5 THz radiation, which show great promise for use as local oscillators in satellite-borne heterodyne radiometers. We present a waveguide-integration scheme, in which a THz QCL is mounted in a copper heat-sink block, with radiation outcoupled into a precision micromachined rectangular waveguide. Electrical bias is provided by an integrated SMA connector and mounting points are provided for attachment to a cryocooler and a temperature sensor. The integration scheme is mechanically robust and is shown to have negligible impact on the thermal performance or threshold current of the device. The emitted beam quality is significantly improved, compared with that of a conventional device, with single-lobed profile with divergence <20 degrees

The Acute Liver Injury in Mice Caused by Nano-Anatase TiO2

Although it is known that nano-TiO2or other nanoparticles can induce liver toxicities, the mechanisms and the molecular pathogenesis are still unclear. In this study, nano-anatase TiO2(5 nm) was injected into the abdominal cavity of ICR mice for consecutive 14 days, and the inflammatory responses of liver of mice was investigated. The results showed the obvious titanium accumulation in liver DNA, histopathological changes and hepatocytes apoptosis of mice liver, and the liver function damaged by higher doses nano-anatase TiO2. The real-time quantitative RT-PCR and ELISA analyses showed that nano-anatase TiO2can significantly alter the mRNA and protein expressions of several inflammatory cytokines, including nucleic factor-κB, macrophage migration inhibitory factor, tumor necrosis factor-α, interleukin-6, interleukin-1β, cross-reaction protein, interleukin-4, and interleukin-10. Our results also implied that the inflammatory responses and liver injury may be involved in nano-anatase TiO2-induced liver toxicity

Waveguide-integrated terahertz-frequency quantum cascade lasers for detection of trace-gas species

We demonstrate high-performance THz QCLs lasing at 2.2, 2.53, 3.5 and 4.7 THz, which target absorption lines of water, methane, hydroxyl and atomic oxygen respectively. Reliable single-mode targeting of gas species is obtained through the use of a photonic lattice design. A highly reproducible micro-machined waveguide block yields narrow beam-divergence and enables future integration of a complete THz heterodyne system including local-oscillator, mixer, and feed-horn

Detection of 2.2-3.5 Terahertz Radiation Using a Quasi-Optically Mounted Planar Schottky Diode

Practical supra-terahertz (1–5 THz) heterodyne radiometry systems require compact local oscillator and mixer components, which are suitable for robust waveguide integration. We demonstrate detection of radiation emitted by quantum cascade lasers at frequencies between 2.2 and 3.5 THz using room-temperature quasi-optically mounted planar Schottky diodes. These diodes are more readily integrated into waveguides than point-contact diodes, do not require the cryogenic environment of hot-electron bolometers and offer potentially better noise performance than superlattice devices

Phylogeography Study of Ammodytes personatus in Northwestern Pacific: Pleistocene Isolation, Temperature and Current Conducted Secondary Contact

To assess the role of historical process and contemporary factors in shaping population structures in Northwestern Pacific, mitochondrial control region sequences were analyzed to characterize the phylogeography and population structure of the Japanese sand lance Ammodytes personatus. A total of 429 individuals sampled from 17 populations through the species' range are sequenced. Two distinct lineages are detected, which might have been divergent in the Sea of Japan and Pacific costal waters of Japanese Island, during the low sea level. Significant genetic structure is revealed between the Kuroshio and Oyashio Currents. However, significant genetic structure is also detected in the Sea of Japan, contracting expected homogenization hypothesis in Tsushima Current. The haplotype frequency of lineages in both sides of Japanese Island and significant genetic structure between north and south groups revealed that the distribution of lineage B and north group were highly limited by the annual sea temperature. The lack of lineage B in Qingdao population with low sea temperature reflects the sea temperature barrier. Lack of genetic structure in the south group and north group populations indicated that ocean currents within groups facilitated the dispersal of A. personatus

I-Motif Structures Formed in the Human c-MYC Promoter Are Highly Dynamic–Insights into Sequence Redundancy and I-Motif Stability

The GC-rich nuclease hypersensitivity element III1 (NHE III1) of the c-MYC promoter largely controls the transcriptional activity of the c-MYC oncogene. The C-rich strand in this region can form I-motif DNA secondary structures. We determined the folding pattern of the major I-motif formed in the NHE III1, which can be formed at near-neutral pH. While we find that the I-motif formed in the four 3′ consecutive runs of cytosines appears to be the most favored, our results demonstrate that the C-rich strand of the c-MYC NHE III1 exhibits a high degree of dynamic equilibration. Using a trisubstituted oligomer of this region, we determined the formation of two equilibrating loop isomers, one of which contains a flipped-out cytosine. Our results indicate that the intercalative cytosine+–cytosine base pairs are not always necessary for an intramolecular I-motif. The dynamic character of the c-MYC I-motif is intrinsic to the NHE III1 sequence and appears to provide stability to the c-MYC I-motif