561 research outputs found
Tungsten disulfide-gold nanohole hybrid metasurfaces for nonlinear metalens in the visible region
Recently, nonlinear hybrid metasurface comes into an attractive new concept
in the research of nanophotonics and nanotechnology. It is composed of
semiconductors with an intrinsically large nonlinear susceptibility and
traditional plasmonic metasurfaces, offering opportunities for efficiently
generating and manipulating nonlinear optical responses. A high second-harmonic
generation (SHG) conversion efficiency has been demonstrated in the
mid-infrared region by using multi-quantum-well (MQW) based plasmonic
metasurfaces. However, it has yet to be demonstrated in the visible region.
Here we present a new type of nonlinear hybrid metasurfaces for the visible
region, which consists of a single layer of tungsten disulfide (WS2) and a
phased gold nanohole array. The results indicate that a large SHG
susceptibility of ~0.1 nm/V at 810 nm is achieved, which is 2~3 orders of
magnitude larger than that of typical plasmonic metasurfaces. Nonlinear
metalenses with the focal lengths of 30 {\mu}m, 50 {\mu}m and 100 {\mu}m are
demonstrated experimentally, providing a direct evidence for both generating
and manipulating SH signals based on the nonlinear hybrid metasurfaces. It
shows great potential applications in designing of integrated, ultra-thin,
compacted and efficient nonlinear optical devices, such as frequency
converters, nonlinear holography and generation of nonlinear optical vortex
beam
Proprioceptive Learning with Soft Polyhedral Networks
Proprioception is the "sixth sense" that detects limb postures with motor
neurons. It requires a natural integration between the musculoskeletal systems
and sensory receptors, which is challenging among modern robots that aim for
lightweight, adaptive, and sensitive designs at a low cost. Here, we present
the Soft Polyhedral Network with an embedded vision for physical interactions,
capable of adaptive kinesthesia and viscoelastic proprioception by learning
kinetic features. This design enables passive adaptations to omni-directional
interactions, visually captured by a miniature high-speed motion tracking
system embedded inside for proprioceptive learning. The results show that the
soft network can infer real-time 6D forces and torques with accuracies of
0.25/0.24/0.35 N and 0.025/0.034/0.006 Nm in dynamic interactions. We also
incorporate viscoelasticity in proprioception during static adaptation by
adding a creep and relaxation modifier to refine the predicted results. The
proposed soft network combines simplicity in design, omni-adaptation, and
proprioceptive sensing with high accuracy, making it a versatile solution for
robotics at a low cost with more than 1 million use cycles for tasks such as
sensitive and competitive grasping, and touch-based geometry reconstruction.
This study offers new insights into vision-based proprioception for soft robots
in adaptive grasping, soft manipulation, and human-robot interaction.Comment: 20 pages, 10 figures, 2 tables, submitted to the International
Journal of Robotics Research for revie
Hybrid High-order Functional Connectivity Networks Using Resting-state Functional MRI for Mild Cognitive Impairment Diagnosis
Conventional functional connectivity (FC), referred to as low-order FC, estimates temporal correlation of the resting-state functional magnetic resonance imaging (rs-fMRI) time series between any pair of brain regions, simply ignoring the potentially high-level relationship among these brain regions. A high-order FC based on "correlation's correlation" has emerged as a new approach for abnormality detection of brain disease. However, separate construction of the low- and high-order FC networks overlooks information exchange between the two FC levels. Such a higher-level relationship could be more important for brain diseases study. In this paper, we propose a novel framework, namely "hybrid high-order FC networks" by exploiting the higher-level dynamic interaction among brain regions for early mild cognitive impairment (eMCI) diagnosis. For each sliding window-based rs-fMRI sub-series, we construct a whole-brain associated high-order network, by estimating the correlations between the topographical information of the high-order FC sub-network from one brain region and that of the low-order FC sub-network from another brain region. With multi-kernel learning, complementary features from multiple time-varying FC networks constructed at different levels are fused for eMCI classification. Compared with other state-of-the-art methods, the proposed framework achieves superior diagnosis accuracy, and hence could be promising for understanding pathological changes of brain connectome
A semi-supervised learning approach to predict synthetic genetic interactions by combining functional and topological properties of functional gene network
<p>Abstract</p> <p>Background</p> <p>Genetic interaction profiles are highly informative and helpful for understanding the functional linkages between genes, and therefore have been extensively exploited for annotating gene functions and dissecting specific pathway structures. However, our understanding is rather limited to the relationship between double concurrent perturbation and various higher level phenotypic changes, e.g. those in cells, tissues or organs. Modifier screens, such as synthetic genetic arrays (SGA) can help us to understand the phenotype caused by combined gene mutations. Unfortunately, exhaustive tests on all possible combined mutations in any genome are vulnerable to combinatorial explosion and are infeasible either technically or financially. Therefore, an accurate computational approach to predict genetic interaction is highly desirable, and such methods have the potential of alleviating the bottleneck on experiment design.</p> <p>Results</p> <p>In this work, we introduce a computational systems biology approach for the accurate prediction of pairwise synthetic genetic interactions (SGI). First, a high-coverage and high-precision functional gene network (FGN) is constructed by integrating protein-protein interaction (PPI), protein complex and gene expression data; then, a graph-based semi-supervised learning (SSL) classifier is utilized to identify SGI, where the topological properties of protein pairs in weighted FGN is used as input features of the classifier. We compare the proposed SSL method with the state-of-the-art supervised classifier, the support vector machines (SVM), on a benchmark dataset in <it>S. cerevisiae </it>to validate our method's ability to distinguish synthetic genetic interactions from non-interaction gene pairs. Experimental results show that the proposed method can accurately predict genetic interactions in <it>S. cerevisiae </it>(with a sensitivity of 92% and specificity of 91%). Noticeably, the SSL method is more efficient than SVM, especially for very small training sets and large test sets.</p> <p>Conclusions</p> <p>We developed a graph-based SSL classifier for predicting the SGI. The classifier employs topological properties of weighted FGN as input features and simultaneously employs information induced from labelled and unlabelled data. Our analysis indicates that the topological properties of weighted FGN can be employed to accurately predict SGI. Also, the graph-based SSL method outperforms the traditional standard supervised approach, especially when used with small training sets. The proposed method can alleviate experimental burden of exhaustive test and provide a useful guide for the biologist in narrowing down the candidate gene pairs with SGI. The data and source code implementing the method are available from the website: <url>http://home.ustc.edu.cn/~yzh33108/GeneticInterPred.htm</url></p
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