Numerical analysis of dielectric micro-particle motion in a fluid and electric field

We present numerical analysis of a coupled problem composed of fluidics, electromagnetic and particle dynamics. The forces acting on the dielectric micro-particle consist of a dielectrophoretic(DEP) force, drag force and gravitational force in the proposed analysis model. DEP force and drag force are calculated using the distribution of the electric field and fluid velocity field to analyze the characteristic of the micro-particle motion. The forces exerted by each field are driving terms in the Newton’s equation for particle motion. The designed particle separating device, which has the one inlet and the two outlets, is simulated to validate proposed numerical scheme. The analysis results show the trace of the micro-particles can be analyzed using the proposed numerical approach

Dieulafoy's Lesion of Jejunum: Presenting Small Bowel Mass and Stricture

Dieulafoy's lesion is an uncommon cause of gastrointestinal bleeding. Hemorrhage occurs through mucosal erosion from an abnormally dilated submucosal artery. Although Dieulafoy's lesion is usually located in the stomach, it may occur anywhere in the gastrointestinal tract. We report here on a case of jejunal Dieulafoy's lesion presenting as a mass and short segment stricture on CT and enteroclysis

Pion and Kaon Electromagnetic Form Factors in a SUL(3)⊗SUR(3)SU_{L}(3)\otimes SU_{R}(3) Effective Lagrangian

A SU(2) effective lagrangian is extended to a $SU_{L}(3)\otimes SU_{R}(3)$ by including the vector and axial vector meson. With this effective lagrangian, electromagnetic form factors of charged pion and kaon are calculated. The pseudoscalar meson loops are taken into account. Good agreement with experimental data is obtained for those form factors. Decay widths of $\rho\to \pi\pi$ and $\phi\to K^{+}K^{-}$ are also calculated and shown to agree with experimental data very well.Comment: 19pages, 7figure

The pseudo scalar form factor of the nucleon, the sigma-like term, and the L0+L_0^+ amplitude for charged pion electro-production near threshold

The pseudo scalar form factor, which represents the pseudo scalar quark density distribution due to finite quark masses on the nucleon, is shown to manifest itself with the induced pseudo scalar form factor in the $L_0^+$ amplitude for the charged pion electro-production. Both form factors show their own peculiar momentum dependence. Under the approximation on which the Goldberg-Treimann relation holds, a sum of both form factors' contributions accounts for the t-channel contribution in the charged pion electro-production near threshold.Comment: 10 page

Crystal structures of murine norovirus-1 RNA-dependent RNA polymerase in complex with 2-thiouridine or ribavirin

AbstractMurine norovirus-1 (MNV-1) shares many features with human norovirus (HuNoV) and both are classified within the norovirus genus of Caliciviridae family. MNV-1 is used as the surrogate for HuNoV research since it is the only form that can be grown in cell culture. HuNoV and MNV-1 RNA dependent RNA polymerase (RdRp) proteins with the sequence identity of 59% show essentially identical conformations. Here we report the first structural evidence of 2-thiouridine (2TU) or ribavirin binding to MNV-1 RdRp, based on the crystal structures determined at 2.2Å and 2.5Å resolutions, respectively. Cellular and biochemical studies revealed stronger inhibitory effect of 2TU on the replication of MNV-1 in RAW 264.7 cells, compared to that of ribavirin. Our complex structures highlight the key interactions involved in recognition of the nucleoside analogs which block the active site of the viral RNA polymerase

Beneficial Effect of Efonidipine, an L- and T-Type Dual Calcium Channel Blocker, on Heart Rate and Blood Pressure in Patients With Mild-to-Moderate Essential Hypertension

Background and Objectives: Efonidipine hydrochloride, an L- and T-type dual calcium channel blocker, is suggested to have a heart rate (HR)-slowing action in addition to a blood pressure (BP)-lowering effect. The aim of this study was to determine the effect of efonidipine on HR and BP in patients with mild-to-moderate hypertension. Subjects and Methods: In a multi-center, prospective, open-labeled, single-armed study, we enrolled 53 patients who had mild-to-moderate hypertension {sitting diastolic BP (SiDBP) 90-110 mmHg}. After a 2-week washout, eligible patients were treated with efonidipine (40 mg once daily for 12 weeks). The primary end point was the change in HR from baseline to week 12. The secondary end-point included the change in trough sitting BP and 24-hour mean BP between baseline and week 12. Laboratory and clinical adverse events were monitored at each study visit (4, 8, and 12 weeks). Results: Fifty-two patients were included in the intention-to-treat analysis. After 12 weeks of treatment with efonidipine, the resting HR decreased significantly from baseline to week 12 (from 81.5??5.3 to 71.8??9.9 beats/minute (difference, -9.9??9.0 beats/minute), p<0.0001}. The trough BP {sitting systolic blood pressure (SiSBP) and SiDBP} and 24-hour mean BP also decreased significantly (SiSBP: from 144.6??8.2 to 132.9??13.5 mmHg, p<0.0001; SiDBP: from 96.9??5.4 to 88.3??8.6 mmHg, p<0.0001, 24-hour mean systolic BP: from 140.4??13.5 to 133.8??11.6 mmHg, p<0.0001; 24-hour mean diastolic BP: from 91.7??8.7 to 87.5??9.5 mmHg, p<0.0001). Conclusion: Efonidipine was effective in controlling both HR and BP in patients with mild-to-moderate hypertension. Copyright ?? 2010 The Korean Society of Cardiology

High-quality thin-film passivation by catalyzer-enhanced chemical vapor deposition for organic light-emitting diodes

The thin-film passivation of organic light-emitting diodes (OLEDs) by a SiNx film grown by catalyzer-enhanced chemical vapor deposition was investigated. Using a tungsten catalyzer connected in series, a high-density SiNx passivation layer was deposited on OLEDs and bare polycarbonate (PC) substrates at a substrate temperature of 50 °C. Despite the low substrate temperature, the single SiNx passivation layer, grown on the PC substrate, exhibited a low water vapor transmission rate of (2–6)×10−2 g/m2/day and a high transmittance of 87%. In addition, current-voltage-luminescence results of an OLED passivated with a 150-nm-thick SiNx film compared to nonpassivated sample were identical indicating that the performance of an OLED is not critically affected by radiation from tungsten catalyzer during the SiNx deposition. Moreover, the lifetime to half initial luminance of an OLED passivated with the single 150-nm-thick SiNx layer was 2.5 times longer than that of a nonpassivated sample.This work was supported by Korea Research Foundation Grant funded by Korea Government (MOEHRD: Basic Research Promotion Fund)(KRF-2006-331-D00243) and Ministry of Commerce, Industry and Energy. Experiments at PLS were supported in part by MOST and POSTECH