Exploring the roles of multidimensional versus unidimensional construct of destination social responsibility in explaining destination trust and relationship continuity

Funding: This study was supported by 2021 Research Grant from Kangwon National University.Peer reviewedPublisher PD

Evaluating Impacts of a Museum-Based Program for Transitional Homeless Adults

Abstract One broad goal of museums is to benefit community members, within their respective museum missions. Some museums are expanding their audiences beyond traditional on-site visitors to broaden and diversify their impacts, including at-risk populations. Evaluation of newly developed museum-based programs is important for program staff, partners, and sponsors to understand effectiveness of, and to find ways to improve, their programs. This study assessed perceived impacts of a museum-based program, Your Story and Mine (YSM), which was developed for homeless adults in mid-Michigan. Semi-structured in-depth interviews were conducted with six program participants. Based on a three-tier “hierarchy of evidence” framework, developed specifically for evaluating the YSM program, responses were coded and categorized into three levels of impacts: i) knowledge/awareness gain; ii) attitude and behavior change; and iii) group development. An emerging fourth response category, “program features” valued by respondents, was added. Participants’ responses reflected their perceptions of program benefits

When Literature is Limited: Using Grant Language and Project Partner Notes to Conceptually Frame a Study

Abstract Expanding beyond traditional roles, some museums are now striving to serve as public learning and social catalyst institutions for their communities. Museums are increasingly engaging with communities to address social, environmental and other complex contemporary issues, sometimes partnering with other institutions and organizations to engage and serve community members. Because these roles and programs are often untested, assessment is critical for identifying potential outcomes, developing recommendations for program improvement, and justifying their existence in a world that increasingly demands accountability. However, literature relevant to museum programs addressing specific social issues is limited. This paper presents an alternative strategy for developing a conceptual framework for a future program assessment, using grant language and project notes as the foundation

Osimertinib in Patients with T790M-Positive Advanced Non-small Cell Lung Cancer: Korean Subgroup Analysis from Phase II Studies

Purpose Osimertinib is a third-generation, irreversible, oral epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) that potently and selectively inhibits both EGFR sensitizing mutation and EGFR T790M and has demonstrated efficacy in non-small cell lung cancer (NSCLC) central nervous system (CNS) metastases. We present results of a subgroup analysis of Korean patients from the pooled data of two global phase II trials: AURA extension (NCT01802632) and AURA2 (NCT02094261). Materials and Methods Enrolled patients had EGFR T790M-positive NSCLC and disease progression during or after EGFR-TKI therapy. Patients received osimertinib 80 mg orally once daily until disease progression. The primary endpoint was objective response rate (ORR). Results In total, 66 Korean patients received osimertinib treatment with a median treatment duration of 19 months. In the evaluable-for-response population (n=62), ORR was 74% (95% confidence interval [CI], 61.5 to 84.5) and median duration of response was 9.8 months (95% CI, 7.1 to 16.8). In the full analysis set (n=66), median progression-free survival was 10.9 months (95% CI, 8.3 to 15.0; data cutoff November 1, 2016), and median overall survival was 29.2 months (95% CI, 24.8 to 35.7; data cutoff May 1, 2018). Eight patients with CNS metastases were evaluable for response, none of whom showed CNS progression. The most common adverse events were rash (53%), cough (33%), paronychia, diarrhea, and decreased appetite (each 32%). Conclusion Efficacy and safety profiles of osimertinib in this subgroup are consistent with the global phase II pooled population, which supports osimertinib as a recommended treatment for Korean patients with T790M positive NSCLC.

Patterns of Post-thyroidectomy Hemorrhage

ObjectivesPostoperative hemorrhage is a potentially life-threatening complication in thyroid surgery. This study was performed to review the clinical patterns of post-thyroidectomy hemorrhage, and especially as they are related to the source of bleeding.MethodsWe performed a retrospective review of 10 patients (0.96%) with post-thyroidectomy hemorrhage that required surgical evacuation. The clinical patterns such as the time interval from surgery to hemorrhage and the signs and symptoms according to the bleeding focus were evaluated.ResultsThe mean time interval from surgery to symptom onset was 7 hr 52 min. Six cases showed bleeding deep to the strap muscles, while the other 4 cases showed bleeding superficial to the muscles. Ecchymosis was prominent and dark in color in 3 of the 4 cases (75%) of superficial bleeding, however it was identified in only 2 of the 6 cases (33%) of deep bleeding. Respiratory distress occurred in two cases of hematoma deep to the strap muscles, but in none of the cases with superficial bleeding.ConclusionThe post-thyroidectomy hemorrhage had some different clinical patterns between the superficial cases and the deep cases, showing that life-threatening airway obstruction occurred from the deep hematoma. A thorough understanding of the clinical patterns of post-thyroidectomy hemorrhage between the cases of superficial and those cases of deep hematoma may provide valuable surgical tips to manage this potentially lethal complication