Effect of Service-Learning on the Multicultural Competence of Teacher Candidates: From a Doing With Community Framework

This article details the findings of a study investigating the effect of service-learning with a Doing With Community framework on teacher candidates’ multicultural attitudes and competence. Fifty-one teacher candidates participated in the research: 27 in an experimental condition and 24 in a comparison classroom. In order to transform the conventional service-learning experience into one incorporating the Doing With framework, a Dialogue with Diverse Families component was included in the experimental condition. A mixed-methods design was employed; specifically, a quasi-experimental design was utilized to obtain quantitative data from measures on multicultural attitudes and competence, and a phenomenological method was used to collect qualitative data from the students’ reflections on project experiences. The service-learning project with the Dialogue With Diverse Families component had a significant effect on teacher candidates’ multicultural competence but not on their multicultural attitudes. This article argues that the Doing With framework of service-learning contributes to teacher candidates’ multicultural competence and civic responsibility

Development and Implementation of a Culturally Responsive Mentoring Program for Faculty and Staff of Color

This paper describes a mentoring program for university employees of color and American Indians that employs a culturally responsive mentoring framework. The mission of the program is to foster a community of support and interdependence to assist members to navigate the university systems, so that members can thrive and, ultimately, be successful. The partnership and collaboration among faculty, staff, and students of color across campus has created a robust mentoring network that has organically grown stronger through the diversity of members represented. This paper discusses the history, goals, components, and outcomes of the culturally responsive mentoring program, and the plans for the future. The paper concludes by offering recommendations for individuals, researchers, and administrators who might consider adopting a similar mentoring program to improve retention, recruitment, and satisfaction of employees of color in their respective higher education institutions

Bioinformatics services for analyzing massive genomic datasets

The explosive growth of next-generation sequencing data has resulted in ultra-large-scale datasets and ensuing computational problems. In Korea, the amount of genomic data has been increasing rapidly in the recent years. Leveraging these big data requires researchers to use large-scale computational resources and analysis pipelines. A promising solution for addressing this computational challenge is cloud computing, where CPUs, memory, storage, and programs are accessible in the form of virtual machines. Here, we present a cloud computing-based system, Bio-Express, that provides user-friendly, cost-effective analysis of massive genomic datasets. Bio-Express is loaded with predefined multi-omics data analysis pipelines, which are divided into genome, transcriptome, epigenome, and metagenome pipelines. Users can employ predefined pipelines or create a new pipeline for analyzing their own omics data. We also developed several web-based services for facilitating down-stream analysis of genome data. Bio-Express web service is freely available at https://www. bioexpress.re.kr/. ?? 2020, Korea Genome Organization

Evidence-based reading instruction for English language learners in preschool through sixth grades: a meta-analysis of group design studies.

University of Minnesota Ph.D. dissertation. August 2009. Major: Educational Psychology. Advisor: Dr. Kristen L. McMaster. 1 computer file (PDF); vii, 133 pages, appendices A-D.The purpose of the study was to synthesize research studies that examined reading instruction for English language learners (ELL) in preschool through sixth grades. Specific goals were to determine the availability of reading instruction for ELLs, the effects of that instruction, and which instructional programs can be considered evidence-based. An extensive search of the research studies identified 29 studies employing group design published in peer-reviewed journals since 1967, which yielded 44 samples with a total of 225 effect sizes. Findings revealed that at both tier 1 and 2, there are more than 10 instructional programs that address phonemic awareness and phonics instruction at preschool to 2nd grade levels, but there were no phonemic awareness and phonics instruction for third to sixth graders. The overall effect of reading instruction was moderate, with a mean ES of 0.50. HLM revealed that factors strengthen the effect were: English as a language of intervention; a session lasted 45 min or less; upper grade level; single grade; average or higher SES; and lower study quality. Three evidence-based or promising practices from 13 programs were identified; Keyword method, Proactive Reading and Peer-Assisted Learning Strategies. The research community should continue to reinforce efforts to improve the quality of research while seeking strong support for rigorous research from policy makers to empower ELL students who are otherwise likely to be at-risk readers by providing them with evidence-based reading instruction

Universal Execution of Parallel Processes: Penetrating NATs over the Grid

Abstract. Today, clusters are very important computing resources and many computing centers manage their clusters in private networks. But parallel programs may not work in private clusters. Because hosts in private clusters are not globally reachable, hosts behind different private clusters cannot be reached directly in order to communicate. It will certainly be a huge loss of resources if private clusters are excluded from the computing due to this reason. There has been much research on this issue, but most of them concentrate on user-level relaying because it is a general and easily-implementable solution. However, even wellimplemented, user-level solutions result in much longer communication latency than kernel-level solutions. This paper adopted a novel kernellevel solution and applied it to MPICH-G2. Our scheme is generally applicable, simple and efficient. The experimental results show that our scheme incurs very little overhead except when small messages are transmitted. That is, it supports a more universal computing environment by including private clusters with remarkably little overhead.

Biological Function and Potential Applications of Garcinol in Human Dental Pulp Stem Cells

IntroductionThe regeneration of pulp tissue is crucial for true regenerative endodontic treatment, which requires a reduction in osteogenic differentiation. Garcinol, a histone acetyltransferase inhibitor, is a natural regulator that is known to suppress the osteogenic differentiation of dental pulp stem cells. In this study, the inhibitory effect of garcinol on the osteogenic differentiation of human dental pulp stem cells (hDPSCs) was evaluated using three-dimensional culture under in vitro and in vivo conditions.MethodshDPSCs were obtained from caries-free third molars and cultured with 10 μM garcinol for 7 days in an ultra-low attachment plate. The cell stemness and expression of osteogenic differentiation-related genes were analyzed using reverse transcription-polymerase chain reaction and single-cell analysis. A transplantation experiment was performed in mice to investigate whether garcinol-treated hDPSCs showed restrained osteogenic differentiation.ResultshDPSCs cultured in the U-shaped ultra-low attachment plate showed the highest expression of stemness-related genes. Garcinol-treated hDPSCs demonstrated downregulation of osteogenic differentiation, with lower expression of bone sialoprotein, which is related to bone formation, and higher expression of dentin sialophosphoprotein, which is related to dentin formation. However, the garcinol-treated hDPSCs did not show any alterations in their stemness. Consistent results were observed in the transplantation experiment in mice.ConclusionsGarcinol reduced the osteogenic differentiation of hDPSCs, which can contribute to true regenerative endodontic treatment

Genetic profiles of subcutaneous panniculitis-like T-cell lymphoma and clinicopathological impact of HAVCR2 mutations

Recent studies identified germline mutations in HAVCR2 (encoding T-cell immunoglobulin mucin 3) as a genetic factor that predisposes to subcutaneous panniculitis-like T-cell lymphoma (SPTCL). However, the differences between HAVCR2-mutated (HAVCR2(MUT)) and HAVCR2 wild-type (HAVCR2(WT)) SPTCLs remain unclear. A nationwide cohort of 53 patients with SPTCL diagnosed at 8 Korean institutions was established. Whole-exome sequencing and RNA-sequencing were performed on 8 patients in the discovery set. In the validation set, targeted gene sequencing or direct sequencing of HAVCR2 was performed. Of 49 patients with available HAVCR2 status, 25 (51.0%) were HAVCR2(Y82C). HAVCR2(Y82C) was associated with younger age (P = .001), development of hemophagocytic lymphohistiocytosis or hemophagocytic lymphohistiocytosis-like systemic illness (P < .001), and short relapse-free survival (RFS) (P = .023). Most mutated genes in SPTCLs were involved in immune responses, epigenetic modifications, and cell signaling. Mutations in UNC13D, PIAS3, and KMT2D were more frequent in HAVCR2(WT) SPTCLs. At the gene expression level, HAVCR2(Y82C) SPTCLs were enriched in genes involved in IL6-JAK-STAT3 signaling and in tumor necrosis factor-alpha signaling via NF-kappa B. CCR4 was significantly upregulated in HAVCR2(WT) SPTCLs both at the messenger RNA level and at the protein level. We established a risk stratification system for SPTCL by integrating clinical and histopathological features, including age and HAVCR2 mutation status. This risk stratification system was strongly associated with RFS (P = .031). In conclusion, the HAVCR2(Y82C) mutation was common in Korean patients with SPTCL and was associated with unique clinicopathological and genetic features. Combining clinicopathological parameters could aid in predicting prognosis for patients with SPTCL.Y