Integrating Service and Academic Study: Service-Learning and Faculty Motivation in Michigan Higher Education

Student involvement in community service projects is viewed primarily as an extra-curricular activity on most college campuses (Kendall, 1990; Lieberman and Connolly, 1992). However, an increasing number of educators are calling for greater integration between service and study through courses which incorporate service-learning (Barber, 1989, 1991, 1992: Nathan and Keilsmeier, 1991; NeWlllan, 1992: Stanton, 1987, 1990; Wieckowski, 1992). Politicians, practitioners, and philosophers offer many arguments to support the inclusion of service-learning in the formal curriculum (Bok, 1982, 1986; Boyer, 1981, 1987; Boyte, 1992; Bradfield and Hyers, 1992; Coles, 1988: Levine, 1989; Stanley, 1989, 1991; Stanton, 1987; Wagner, 1990). This chorus of support for service-learning is generally rooted in a commitment to volunteer ism and has three recurrent strains: service-learning contributes to the vitality of the college or university; service-learning promotes civic responsibility which strengthens the nation; and service-learning contributes to the solution cf problems in the wider society (Agria, 1990: Barber, 1992: Conrad and Hedin, 1987: Delve, Mintz and Stewart, 1990; Fitch, 1987)

Emerging Microbial and Viral Infections of the Central Nervous System

This review focuses on emerging viral and bacterial infections in the human central nervous system (CNS) that are responsible for significant global morbidity and mortality. These infections include those responsible for acute neurological disease such as meningitis and encephalitis as well those associated with chronic neurodegenerative conditions. Recent changes in climate conditions and pollution have been precipitating factors leading to the emergence of many of these pathogenic organisms. In addition, increased urbanization, global travel, life span, and exposure to new vectors have promoted the organisms’ spread across the globe. Categorization of many of these organisms includes identification of new species, recognition of new tropism to the CNS, spread into naïve demographic areas, increased human contact with zoonotic repositories including insect vectors, and reemergence of well-known organisms. These mechanisms are highlighted for the different organisms included in this review. Other mechanisms for CNS emergence such as genetic mutation of the organisms and immunosuppression and/or immunosenescence of the host are addressed. Viral and bacterial infections in chronic neurodegenerative diseases traditionally not thought to be infectious are considered. Although this review cannot be all-inclusive, the organisms included represent a sampling of extremely important microbes and their role in CNS pathogenesis in the twenty-first century

Consistent use of a combination product versus a single product in a safety trial of the diaphragm and microbicide in Harare, Zimbabwe.

BACKGROUND: We examined the use and acceptability of a combination product (diaphragm and gel) compared to a single product (gel) during a 6-month safety trial in Zimbabwe. STUDY DESIGN: Women were randomized to the use of a diaphragm with gel or the use of gel alone, in addition to male condoms. Ever use and use of study product on the last act of sexual intercourse were assessed monthly by Audio Computer-Assisted Self-Interviewing. Acceptability, correct use and consistent use (use at every sexual act during the previous 3 months) were measured on the last visit by face-to-face interview. Predictors of consistent use were examined using multivariate logistic regression analyses. RESULTS: In this sample of 117 sexually active, monogamous, contracepting women, rates of consistent use were similar in both groups (59.7% for combination method vs. 56.4% for gel alone). Product acceptability was high, but was not independently associated with consistent use. Independent predictors of consistent use included age [adjusted odds ratio (AOR)=1.08; 95% confidence interval (95% CI)=1.01-1.16], consistent condom use (AOR=3.85; 95% CI=1.54-9.63) and having a partner who approves of product use (AOR=2.66; 95% CI=1.10-6.39). CONCLUSIONS: Despite high reported acceptability and few problems with the products, the participants reported only moderate product adherence levels. Consistent use of condoms and consistent use of products were strongly associated. If observed in other studies, this may bias the estimation of product effectiveness in future trials of female-controlled methods

Particle Size Distribution in Aluminum Manufacturing Facilities.

As part of exposure assessment for an ongoing epidemiologic study of heart disease and fine particle exposures in aluminum industry, area particle samples were collected in production facilities to assess instrument reliability and particle size distribution at different process areas. Personal modular impactors (PMI) and Minimicro-orifice uniform deposition impactors (MiniMOUDI) were used. The coefficient of variation (CV) of co-located samples was used to evaluate the reproducibility of the samplers. PM2.5 measured by PMI was compared to PM2.5 calculated from MiniMOUDI data. Mass median aerodynamic diameter (MMAD) and concentrations of sub-micrometer (PM1.0) and quasi-ultrafine (PM0.56) particles were evaluated to characterize particle size distribution. Most of CVs were less than 30%. The slope of the linear regression of PMI_PM2.5 versus MiniMOUDI_PM2.5 was 1.03 mg/m3 per mg/m3 (± 0.05), with correlation coefficient of 0.97 (± 0.01). Particle size distribution varied substantively in smelters, whereas it was less variable in fabrication units with significantly smaller MMADs (arithmetic mean of MMADs: 2.59 μm in smelters vs. 1.31 μm in fabrication units, p = 0.001). Although the total particle concentration was more than two times higher in the smelters than in the fabrication units, the fraction of PM10 which was PM1.0 or PM0.56 was significantly lower in the smelters than in the fabrication units (p < 0.001). Consequently, the concentrations of sub-micrometer and quasi-ultrafine particles were similar in these two types of facilities. It would appear, studies evaluating ultrafine particle exposure in aluminum industry should focus on not only the smelters, but also the fabrication facilities

Using relationships as a tool: early childhood educators’ perspectives of the child–caregiver relationship in a childcare setting

Children's early years are critical for development and many children access out-of-home care during this time. Services offering high-quality childcare afford an opportunity to impact positively on children's development, including acquisition of communication skills. A strong, responsive relationship between child and carer is important in facilitating children's communication development. For infants who are not yet verbal, early childhood educators (ECEs) need to be highly sensitive to the child's communication, and they need to develop a relationship with the child to interpret their signals and facilitate their communication. This study investigated the perspectives of ECEs on their relationships with infants in their care. Individual semi-structured interviews with ECEs were conducted and the interview data were triangulated with videoed observational data. The results demonstrate that these ECEs use the relationship with the children in their care as a tool for provision of optimal learning experiences across multiple developmental domains

Temporal variability of GNSS-Reflectometry ocean wind speed retrieval performance during the UK TechDemoSat-1 mission

This paper presents the temporal evolution of Global Navigation Satellite System Reflectometry (GNSS-R) ocean wind speed retrieval performance during three years of the UK TechDemoSat-1 (TDS-1) mission. TDS-1 was launched in July 2014 and provides globally distributed spaceborne GNSS-R data over a lifespan of over three years, including several months of 24/7 operations. TDS-1 wind speeds are computed using the NOC Calibrated Bistatic Radar Equation algorithm version 0.5 (C-BRE v0.5), and are evaluated against ERA5 high resolution re-analysis data over the period 2015–2018. Analyses reveal significant temporal variability in TDS-1 monthly wind speed retrieval performance over the three years, with the best performance (~2 m∙s−1) achieved in the early part of the mission (May 2015). The temporal variability of retrieval performance is found to be driven by several non-geophysical factors, including TDS-1 platform attitude uncertainty and spatial/temporal changes in GPS transmit power from certain satellites. Evidence is presented of the impact of the GPS Block IIF Flex mode on retrieved GNSS-R wind speed after January 2017, which results in significantly underestimated ocean winds over a large region covering the North Atlantic, northern Indian Ocean, the Mediterranean, the Black Sea, and the Sea of Okhotsk. These GPS transmit power changes are shown to induce large negative wind speed biases of up to 3 m∙s−1. Analyses are also presented of the sensitivity of TDS-1 wind speed retrieval to platform attitude uncertainty using statistical simulations. It is suggested that a 4° increase in attitude uncertainty can produce up to 1 m∙s−1 increase in RMSE, and that TDS-1 attitude data do not fully reflect actual platform attitude. We conclude that the lack of knowledge about the GNSS-R nadir antenna gain map and TDS-1 platform-attitude limits the ability to determine the achievable wind speed retrieval performance with GNSS-R on TDS-1. The paper provides recommendations that accurate attitude knowledge and a good characterisation of GNSS-R nadir antenna patterns should be prioritised for future GNSS-R missions

A quasi-experimental study of a mandatory calorie-labelling policy in restaurants: Impact on use of nutrition information among youth and young adults in Canada

The final publication is available at Elsevier via https://dx.doi.org/10.1016/j.ypmed.2018.09.013 © 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/In 2017, Ontario became the first Canadian province to require calorie amounts on menus/menu boards of chain restaurants. The province of British Columbia (BC) implemented a voluntary nutrition information initiative in which calorie and sodium information were available upon request. A quasi-experimental design was used to examine the use of nutrition information in Ontario (mandatory calorie labelling), compared to BC (voluntary policy) and three other provinces with no formal menu labelling policy (‘control’). Data were collected from youth and young adults (16–30 years) in all provinces pre- (fall 2016; n = 2929) and post- (fall 2017; n = 968) implementation of Ontario's calorie-labelling policy in January 2017. Generalized estimating equations tested differences between provinces over time in noticing and impact of nutrition information and support of mandatory calorie labelling. Noticing of nutrition information in restaurants increased in Ontario significantly more than in BC (+25.1% vs. +1.6%; AOR = 4.26, 95% CI = 2.39–7.61) and control provinces (+6.5%; AOR = 3.00, 95% CI = 1.91–4.73). Ontario respondents were significantly more likely to report that the nutrition information influenced their order than those in BC (+12.9% vs. +2.2%; AOR = 3.53, 95%CI = 1.61–7.76) and control provinces (+2.0%; AOR = 3.71, 95%CI = 1.87–7.36). Policy support increased in all groups at follow-up, with a significantly greater increase in Ontario than control provinces (+12.9% vs. +5.7%; AOR = 1.57, 95%CI = 1.06–2.34). Socio-demographic differences were also observed. Findings suggest that the mandatory menu labelling policy implemented in Ontario has increased noticing and use of nutrition information, with no evidence to support the effectiveness of voluntary policies that require consumers to request nutrition information.Public Health Agency of Canad

Chlamydia pneumoniae Infection of Monocytes in vitro Stimulates Innate and Adaptive Immune Responses Relevant to those in Alzheimer\u27s Disease.

Background: Alzheimer\u27s disease (AD) is a progressive neurodegenerative disorder in which infection with Chlamydia pneumoniae (Cpn) has been associated. Cpn is an obligate intracellular respiratory pathogen that may enter the central nervous system (CNS) following infection and trafficking of monocytes through the blood-brain barrier. Following this entry, these cells may secrete pro-inflammatory cytokines and chemokines that have been identified in the AD brain, which have been thought to contribute to AD neurodegeneration. The objectives of this work were: (i) to determine if Cpn infection influences monocyte gene transcript expression at 48 hours post-infection and (ii) to analyze whether pro-inflammatory cytokines are produced and secreted from these cells over 24 to 120 hours post-infection. Methods: Gene transcription was analyzed by RT-PCR using an innate and adaptive immunity microarray with 84 genes organized into 5 functional categories: inflammatory response, host defense against bacteria, antibacterial humoral response, septic shock, and cytokines, chemokines and their receptors. Statistical analysis of the results was performed using the Student\u27s t-test. P-values ≤ 0.05 were considered to be significant. ELISA was performed on supernatants from uninfected and Cpn-infected THP1 monocytes followed by statistical analysis with ANOVA. Results: When Cpn-infected THP1 human monocytes were compared to control uninfected monocytes at 48 hours post-infection, 17 genes were found to have a significant 4-fold or greater expression, and no gene expression was found to be down-regulated. Furthermore, cytokine secretion (IL-1ß, IL-6, IL-8) appears to be maintained for an extended period of infection. Conclusions: Utilizing RT-PCR and ELISA techniques, our data demonstrate that Cpn infection of THP1 human monocytes promotes an innate immune response and suggests a potential role in the initiation of inflammation in sporadic/late-onset Alzheimer\u27s disease

Socio-demographic characteristics, diet and health among food insecure UK adults: cross-sectional analysis of the International Food Policy Study.

OBJECTIVE: To estimate food insecurity (FI) prevalence among UK adults and investigate associations with socio-demographic characteristics, diet and health. DESIGN: Weighted cross-sectional survey data. FI was measured using the USDA Adult Food Security Survey Module. Data were analysed using adjusted logistic regression models. SETTING: United Kingdom. PARTICIPANTS: 2551 participants (aged 18-64 years); sub-sample (n 1949) used to investigate association between FI and overweight. RESULTS: FI prevalence was 24·3 %. Higher odds of FI were observed among participants who reported that making ends meet was difficult v. easy (OR 19·76, 95 % CI 13·78, 28·34), were full-time students v. non-students (OR 3·23, 95 % CI 2·01, 5·18), had low v. high education (OR 2·30, 95 % CI 1·66, 3·17), were male v. female (OR 1·36, 95 % CI 1·01, 1·83) and reported their ethnicity as mixed (OR 2·32, 95 % CI 1·02, 5·27) and white other (OR 2·04, 95 % CI 1·04, 3·99) v. white British. Odds of FI were higher in participants living with children v. alone, especially in single-parent households (OR 2·10, 95 % CI 1·19, 3·70). Odds of FI decreased per year of increase in age (OR 0·95, 95 % CI 0·94, 0·96) and were lower in participants not looking for work v. full-time employed (OR 0·60, 95 % CI 0·42, 0·87). Food insecure v. food secure adults had lower odds of consuming fruits (OR 0·59, 95 % CI 0·47, 0·74) and vegetables (OR 0·68, 95 % CI 0·54, 0·86) above the median frequency, and higher odds for fruit juice (OR 1·39, 95 % CI 1·10, 1·75). Food insecure v. food secure adults had higher odds of reporting unhealthy diets (OR 1·65, 95 % CI 1·31, 2·10), poor general health, (OR 1·90, 95 % CI 1·50, 2·41), poor mental health (OR 2·10, 95 % CI 1·64, 2·69), high stress (OR 3·15, 95 % CI 2·42, 4·11) and overweight (OR 1·32, 95 % CI 1·00, 1·75). CONCLUSIONS: FI prevalence was high and varied by socio-demographic characteristics. FI was associated with poorer diet and health.AY is funded via a CEDAR PhD studentship. JA and MW are funded by the University of Cambridge and CEDAR. Funding for CEDAR from Cancer Research UK, British Heart Foundation, Economic and Social Research Council (grant number ES/G007462/1), Medical Research Council (grant number MR/K023187/1), National Institute for Health Research, and Wellcome Trust (grant number 087636/Z/08/Z) is gratefully acknowledged. Funding for the International Food Policy Study was provided by a Population Health Intervention Research operating grant from the Canadian Institutes of Health Research (CIHR). Additional funding for this project has been provided by a PHAC – CIHR Chair in Applied Public Health (DH). The funders had no role in study design, data collection, data analysis, data interpretation, or writing of the manuscript

Herpes simplex virus type 1 and Chlamydia pneumoniae infection of astrocytes: the effects of co-infection on pathogen replication

Background: Chlamydia pneumoniae (Cpn) and Herpes simplex virus type 1 (HSV-1) have been studied as pathogens contributing to neurodegenerative diseases. Cpn and HSV-1 are both ubiquitous, thus many individuals presumably are exposed to both pathogens during their life time. Since Cpn can establish persistence under adverse environmental conditions, we speculate that productive HSV infection might induce Cpn persistence in cells infected with both pathogens. Intermittent reactivation of either or both pathogens might contribute to progressive pathology associated with neurodegenerative diseases. Objectives: Determine whether Cpn and HSV-1 can co-infect cells and whether the presence of one pathogen alters replication of the other. Methods: The ability of Cpn and HSV-1 to co-infect an astrocyte cell line (STTG-1) was analyzed by immunofluorescence (IF) labeling using antibodies specific for HSV and Cpn, and RT-PCR using primers specific for each pathogen. Cells were infected with HSV or Cpn alone, or co infected with both pathogens for 24 or 48 hours. Results: IF revealed that cells could be simultaneously infected with both pathogens. Gene expression data support the observation that HSV replication is somewhat diminished in the presence of Cpn; similarly, the developmental cycle of Cpn appears to be disrupted by HSV. Conclusions: IF and gene expression data suggest both HSV-1 and Cpn inhibit, but do not prevent, infection by the second pathogen, possibly by competing for the same cellular receptors. Moreover, disruption of host cell transcription by HSV-1 may modify normal Cpn developmen