Influence of Tool Variables on Wear when Milling Iron Aluminide Alloy Fe25Al1.5Ta [at.-%]

Non-ferrous high-performance materials such as titanium- and nickel-base alloys are of great importance for the aerospace industry due to their advantageous properties. However, the high material prices of these alloys are a disadvantage. At the same time, iron aluminide alloys can feature similar mechanical and thermal properties combined with a significant economic advantage over other high-performance alloys. Thus, iron aluminides present a promising alternative to high priced non-ferrous alloys and have the potential to substitute established materials for components such as turbine blades. In aerospace part production, milling represents an important finishing process. Iron aluminides are considered difficult to cut materials. Therefore, occurring tool wear and its mechanisms are the primary issues in machining. These topics are not yet covered in depth by the prevailing knowledge base. In this paper, near-net-shape cast iron aluminide cross-samples were machined using ball end milling cutters to analyze the occurring tool wear and the performance of different milling tool systems. The results show a fundamental influence of the tungsten carbide substrate and the tool coating on tool wear when milling iron aluminide. The tools' macro and micro geometry affect the active forces and stabilize the cutting edge. The present study provides insights about preferable tool variables that contribute to extending tool life in iron aluminide turbine blade production

Religionsfreiheit, evangelikale Lobby und US-Außenpolitik

Schade J. Religionsfreiheit, evangelikale Lobby und US-Außenpolitik. In: Bielefeldt H, Deile V, Hamm B, Hutter F-J, Kurtenbach S, Tretter H, eds. Religionsfreiheit. Jahrbuch Menschenrechte. Vol 2009. Wien: Böhlau; 2008: 139-151

Candidose der Haut

Seebacher C, Abeck D, Brasch J, et al. Candidose der Haut. Journal der Deutschen Dermatologischen Gesellschaft (JDDG). 2006;4(7):591-596

Tinea der freien Haut

Seebacker C, Korting HC, Abeck D, et al. Tinea der freien Haut. Journal der Deutschen Dermatologischen Gesellschaft (JDDG). 2005;3(11):921-926

Onychomykose

Seebacher C, Brasch J, Abeck D, et al. Onychomycosis. Journal der Deutschen Dermatologischen Gesellschaft (JDDG). 2007;5(1):61-66.Dt. Version erschienen u.d.T.: Onychomykose ([https://doi.org/10.1111/j.1610-0387.2007.06134_supp.x]( https://doi.org/10.1111/j.1610-0387.2007.06134_supp.x)

Tinea of glabrous skin

Seebacher C, Korting HC, Abeck D, et al. Tinea of glabrous skin. Journal der Deutschen Dermatologischen Gesellschaft. 2010;8(7):549-554

Cysteine-Rich Angiogenic Inducer 61 Improves Prognostic Accuracy of GRACE (Global Registry of Acute Coronary Events) 2.0 Risk Score in Patients With Acute Coronary Syndromes

Background It remains unclear whether the novel biomarker cysteine-rich angiogenic inducer 61 (CCN1) adds incremental prognostic value to the GRACE 2.0 (Global Registry of Acute Coronary Events) risk score and biomarkers high-sensitivity Troponin T, hsCRP (high-sensitivity C-reactive protein), and NT-proBNP (N-terminal pro-B-type natriuretic peptide) in patients with acute coronary syndromes. Methods and Results Patients referred for coronary angiography with a primary diagnosis of acute coronary syndromes were enrolled in the Special Program University Medicine - Acute Coronary Syndromes and Inflammation cohort. The primary/secondary end points were 30-day/1-year all-cause mortality and the composite of all-cause mortality or myocardial infarction as used in the GRACE risk score. Associations between biomarkers and outcome were assessed using log-transformed biomarker values and the GRACE risk score (versions 1.0 and 2.0). The incremental value of CCN1 beyond a reference model was assessed using Harrell's C-statistics calculated from a Cox proportional-hazard model. The P value of the C-statistics was derived from a likelihood ratio test. Among 2168 patients recruited, 1732 could be analyzed. CCN1 was the strongest single predictor of all-cause mortality at 30 days (hazard ratio [HR], 1.77 [1.31, 2.40]) and 1 year (HR, 1.81 [1.47, 2.22]). Adding CCN1 alone to the GRACE 2.0 risk score improved C-statistics for prognostic accuracy of all-cause mortality at 30 days (0.87-0.88) and 1 year (0.81-0.82) and when combined with high-sensitivity Troponin T, hsCRP, NT-proBNP for 30 days (0.87-0.91), and for 1-year follow-up (0.81-0.84). CCN1 also increased the prognostic value for the composite of all-cause mortality or myocardial infarction. Conclusions CCN1 predicts adverse outcomes in patients with acute coronary syndromes adding incremental information to the GRACE risk score, suggesting distinct underlying molecular mechanisms. Registration URL: https://www.clinicaltrials.gov. Unique identifier: NCT01000701

Orale candidiasis

Reinel D, Plettenberg A, Seebacher C, et al. Orale Candidose. Journal der Deutschen Dermatologischen Gesellschaft. 2008;6(7):593-597