Market Structure and International Trade: Business Groups in East Asia

In this paper we study the effect of market structure on the trade performance of South Korea, Taiwan, and Japan. We center our analysis on Korea and Taiwan, countries which have very different market structures: Korea has many large, vertically-integrated business groups known as chaebol, whereas business groups in Taiwan are smaller and horizontally-integrated in the production of intermediate inputs. The exports of these countries to the United States are compared using indexes of product variety and 'product mix', which are constructed at the 5-digit industry level. It is found that Taiwan tends to export a greater variety of products to the U.S. than Korea, and this holds across nearly all industries. In addition, Taiwan exports relatively more high-priced intermediate inputs, whereas Korea exports relatively more high-priced final goods. We argue that these results confirm the importance of market structure as a determinant of trade patterns.

Phylogenetic identification of lateral genetic transfer events

BACKGROUND: Lateral genetic transfer can lead to disagreements among phylogenetic trees comprising sequences from the same set of taxa. Where topological discordance is thought to have arisen through genetic transfer events, tree comparisons can be used to identify the lineages that may have shared genetic information. An 'edit path' of one or more transfer events can be represented with a series of subtree prune and regraft (SPR) operations, but finding the optimal such set of operations is NP-hard for comparisons between rooted trees, and may be so for unrooted trees as well. RESULTS: Efficient Evaluation of Edit Paths (EEEP) is a new tree comparison algorithm that uses evolutionarily reasonable constraints to identify and eliminate many unproductive search avenues, reducing the time required to solve many edit path problems. The performance of EEEP compares favourably to that of other algorithms when applied to strictly bifurcating trees with specified numbers of SPR operations. We also used EEEP to recover edit paths from over 19 000 unrooted, incompletely resolved protein trees containing up to 144 taxa as part of a large phylogenomic study. While inferred protein trees were far more similar to a reference supertree than random trees were to each other, the phylogenetic distance spanned by random versus inferred transfer events was similar, suggesting that real transfer events occur most frequently between closely related organisms, but can span large phylogenetic distances as well. While most of the protein trees examined here were very similar to the reference supertree, requiring zero or one edit operations for reconciliation, some trees implied up to 40 transfer events within a single orthologous set of proteins. CONCLUSION: Since sequence trees typically have no implied root and may contain unresolved or multifurcating nodes, the strategy implemented in EEEP is the most appropriate for phylogenomic analyses. The high degree of consistency among inferred protein trees shows that vertical inheritance is the dominant pattern of evolution, at least for the set of organisms considered here. However, the edit paths inferred using EEEP suggest an important role for genetic transfer in the evolution of microbial genomes as well

HST Images and Spectra of the Remnant of SN 1885 in M31

Near UV HST images of the remnant of SN 1885 (S And) in M31 show a 0"70 +- 0"05 diameter absorption disk silhouetted against M31's central bulge, at SN 1885's historically reported position. The disk's size corresponds to a linear diameter of 2.5 +- 0.4 pc at a distance of 725 +- 70 kpc, implying an average expansion velocity of 11000 +- 2000 km/s over 110 years. Low-dispersion FOS spectra over 3200-4800 A; reveal that the absorption arises principally from Ca II H & K (equivalent width ~215 A;) with weaker absorption features of Ca I 4227 A; and Fe I 3720 A;. The flux at Ca II line center indicates a foreground starlight fraction of 0.21, which places SNR 1885 some 64 pc to the near side of the midpoint of the M31 bulge, comparable to its projected 55 pc distance from the nucleus. The absorption line profiles suggest an approximately spherically symmetric, bell-shaped density distribution of supernova ejecta freely expanding at up to 13100 +- 1500 km/s. We estimate Ca I, Ca II, and Fe I masses of 2.9(+2.4,-0.6) x 10^-4 M_o, 0.005(+0.016,-0.002) M_o, and 0.013(+0.010,-0.005) M_o respectively. If the ionization state of iron is similar to the observed ionization state of calcium, M_CaII/M_CaI = 16(+42,-5), then the mass of Fe II is 0.21(+0.74,-0.08) M_o, consistent with that expected for either normal or subluminous SN Ia.Comment: 8 pages, including 4 embedded EPS figures, emulateapj.sty style file. Color image at http://casa.colorado.edu/~mcl/sand.shtml . Submitted to Ap

Diagnostic evaluation of food-related allergic diseases

Food allergy is a serious and potentially life-threatening problem for an estimated 6% of children and 3.7% of adults. This review examines the diagnostic process that begins with a patient's history and physical examination. If the suspicion of IgE-mediated food allergy is compelling based on the history, skin and serology tests are routinely performed to provide confirmation for the presence of food-specific IgE antibody. In selected cases, a provocation challenge may be required as a definitive or gold standard reference test for confirmation of IgE mediated reactions to food. Variables that influence the accuracy of each of the diagnostic algorithm phases are discussed. The clinical significance of food allergen-specific IgE antibody cross-reactivity and IgE antibody epitope mapping of food allergens is overviewed. The advantages and limitations of the various diagnostic procedures are examined with an emphasis on future trends in technology and reagents

Chemical and Physical Properties of Tumor-Affected Sitka Spruce

The chemical composition, fiber properties, and pulpability of a Sitka spruce (Picea sitchensis) massive trunk and root tumor were compared with normal second-growth wood. In general appearance the tumored tissue looked like normal wood in that it had annual rings and definite sapwood and heartwood zones. However, the trunk tumor showed no visible evidence of compression wood, whereas the trunk of the affected tree above and below the tumor contained about 30% compression wood. The tumor tracheids were short, curved, and twisted; and numerous traumatic resin canals were present. The wood rays and bark showed no apparent abnormalities. Paper prepared from kraft pulp tumor wood was lower in burst, tear, tensile, and opacity, and higher in fold and shrinkage, density and air resistance compared to pulp from the second-growth control. Chemical analysis indicated that the tumor-affected tree had a higher hemicellulose content, primarily as galactan-containing polymers, than the second-growth control. The factor causing the tumor growth was not ascertained in this study

Facilitation of penicillin haptenation to serum proteins.

Traditionally, penicillin binding to serum proteins was believed to be a passive chemical process; however, it appears to be facilitated by serum factors. The objectives of this in vitro investigation were to examine facilitated penicillin haptenation, to study the kinetics of haptenation, and to determine the nature of haptenation-facilitating factors. The model involved addition of [3H]benzylpenicillin to serum or albumin solutions (at pH 7.3 to 7.4) and incubation at 37 degrees C for up to 72 h. The extent of penicillin binding to proteins in serum was found to be four- to fivefold higher than with solutions having comparable concentrations of purified albumin, total protein, or total immunoglobulin. Ultrafiltration of serum reduced penicillin binding to serum proteinssubstantially. An ultrafiltrable haptenation-facilitating factor(s) was found to be less than 0.5 kDa but was not calcium or magnesium. Finally, the extent of penicillin binding was related to albumin purity, as binding substantially increased with albumin purity. These findings suggest that there is a factor(s) in serum that facilitates covalent binding of penicillin to serum proteins. The factor(s) can be removed and then restored to increase penicillin binding to albumin. It appears that at least one component of the facilitation factor is less than 0.5 kDa, which suggests that it is not a peptide and that it is some simple serum component other than calcium or magnesium

A compactness theorem for complete Ricci shrinkers

We prove precompactness in an orbifold Cheeger-Gromov sense of complete gradient Ricci shrinkers with a lower bound on their entropy and a local integral Riemann bound. We do not need any pointwise curvature assumptions, volume or diameter bounds. In dimension four, under a technical assumption, we can replace the local integral Riemann bound by an upper bound for the Euler characteristic. The proof relies on a Gauss-Bonnet with cutoff argument.Comment: 28 pages, final version, to appear in GAF

A Selective Irreversible Inhibitor of Furin Does Not Prevent Pseudomonas Aeruginosa Exotoxin A-Induced Airway Epithelial Cytotoxicity

Many bacterial and viral pathogens (or their toxins), including Pseudomonas aeruginosa exotoxin A, require processing by host pro-protein convertases such as furin to cause disease. We report the development of a novel irreversible inhibitor of furin (QUB-F1) consisting of a diphenyl phosphonate electrophilic warhead coupled with a substrate-like peptide (RVKR), that also includes a biotin tag, to facilitate activity-based profiling/visualisation. QUB-F1 displays greater selectivity for furin, in comparison to a widely used exemplar compound (furin I) which has a chloromethylketone warhead coupled to RVKR, when tested against the serine trypsin-like proteases (trypsin, prostasin and matriptase), factor Xa and the cysteine protease cathepsin B. We demonstrate QUB-F1 does not prevent P. aeruginosa exotoxin A-induced airway epithelial cell toxicity; in contrast to furin I, despite inhibiting cell surface furin-like activity to a similar degree. This finding indicates additional proteases, which are sensitive to the more broad-spectrum furin I compound, may be involved in this process