1 research outputs found
In Vitro Antiplasmodial Activity and Cytotoxic Effect of (Z)-2-Benzylidene-4, 6-Dimethoxybenzofuran-3 (2H)-One Derivatives
Background: Aurones are naturally occurring compounds that belong to flavenoids
family and have antiplasmodial effects. This study investigated some new aurones
derivatives against chloroquine sensitive Plasmodium falciparum. Here we report
the synthesis, in vitro antiplasmodial activity and cytotoxic evaluation of 11 compound
from derivatives of (Z)-2- benzylidene-4, 6-dimethoxybenzofuran-3(2H)-
one.
Methods: The cytotoxic evaluations of active compounds were performed with
MTT (3-[4, 5-dimethylthiazol-2-yl]-2, 5 diphenyltetrazolium bromide) assay on human
breast cancer cell lines; MCF7 and T47D.
Results: From 11 compounds M3, M6 and M7 compounds showed good antiplasmodial
effect against chloroquine-sensitive 3D strain of P. falciparum with IC50
(50% inhibitory concentration) values of 7.82, 7.27 and 2.3 µM respectively. No
noticeable toxicity was observed with these compounds when tested against tested
cell lines.
Conclusion: The replacement of the 4 and 5 positions at ring B of aurone derivatives,
with propoxy and bromide (Br) respectively was revealed highly advantageous
for their antiplasmodial effect