メキシレチン ニヨル ヤクザイセイ カビンショウ ショウコウグン ノ 1レイ

73歳,男性.既往歴に高血圧症と不整脈がある. 2005年10月中旬よりメキシレチン,ニルバジピンの内服を開始し, 2ケ月後に高熱と多形紅班型中毒疹が出現した.顔面浮腫,末梢血白血球数増多,好酸球数増多,肝機能障害を伴った.プレドニン45mg/day内服で治療を開始し,その後症状の改善に伴いプレドニンを漸減, 19日後に投与を中止したところ,皮疹の再燃を認めた.薬剤貼付試験はメキシレチンのみで陽性であり,リンパ球刺激試験は陰性であった.末梢血HHV-6IgG抗体(EIA)は入院時2倍4週間後に8倍であった.以上からメキシレチンによる薬剤性過敏症症候群と診断した.自験例を含めた1991年から2006年までのメキシレチンの薬剤性過敏症症候群47例を集計した結果, DIHS全体の報告と比較して多くの所見はほぼ同じ傾向であったがメキシレチンによるDIHSでは腎障害の頻度が明らかに高かった.A 76-year-old man had been administered mexiletine hydrochloride for arrhythmia for 8 weeks, when he developed a skin eruption on his face and whole of the body. A fever of 39@@@ continued, and nail-sized erythematous plaques developed on his whole body. Laboratory studies showed a leukocytosis, an eosinophilia and a liver dysfunction. Patch testing against mexiletine hydrocholoride showed positive results, though DLST showed negative results. Serological test for HHV-6, performed on the admission and 4 weeks after the admission, revealed an increase in the antibody tier with values from 2 to 8. A diagnosis of drug-induced hypersensitivity syndrome due to mexiletine hydrochloride was made. The patient was treated with oral application of prednisolone

PIDを用いた安全な社会システムの構想

マルチメディア，分散，協調とモバイル（DICOMO2002

A Proposal of Secure Information Infrastructure based on PID

As a background of the rapid progress of the network, various electronic services proceed steadly. It thinks that we become more convenient, and more efficient by the introduction of these services. But on the other hand, it is a big subject that there are many security problems because of electronic. It is very important to build the society which keeps those damages to a minimum. So we don\u27t only apply security technology to the existent society. Building of the secure information infrastructure as a cause of the definite concept. By this thesis, we proposed some concepts, modelled, and verified

A Proposal of Secure Infomation Infrastructure based on PID

マルチメディア，分散，協調とモバイル（DICOMO2002

A Proposal of Secure Infomation Infrastructure based on PID

As a background of the rapid progress of the network, various electronic services proceed steadly. It thinks that we become more convenient, and more efficient by the introduction of these services. But on the other hand, it is a big subject that there are many security problems because of electronic. It is very important to build the society which keeps those damages to a minimum. So we don\u27t only apply security technology to the existent society. Building of the secure information infrastructure as a cause of the definite concept. By this thesis, we proposed some concepts, modeled, and verified