Binding of Small Molecules and Metallic Complexes to DNA: A Methodological Approach

International audienc

Self-assembled Lanthanide Complexes: Thermodynamic and Kinetic Aspects (Keynote lecture)

International audienc

Self-Assembly of Polynuclear Arrays for Sensing Purposes.

International audienc

Unravelling self-assembly of lanthanide helicates: Switching from deduction to induction

International audienceClassical supramolecular approach involving thermodynamic and kinetic characterisation is discussed for polymetallic lanthanide complexes with neutral ligands. These experimental studies allow (i) to obtain the stability constants of the self-assembled species and (ii) to establish the formation mechanism. Consequently, the analysis of these data with thermodynamic models promotes a deeper rationalization of self-assembly. The quantitative energetic parametrization of inter- and intra-molecular processes together with intermetallic and interligand interactions is obtained for europium(III) complexes of similar structure. To confirm the predictive ability of this thermodynamic modelling, the stability constant of the homologous tetrametallic helicate [Eu4(L4)3]12+ has been computed. An excellent agreement between the predicted and the experimental value of demonstrates the power of this innovative approach for supramolecular programming

Speciation in PolynuclearAssemblies with Lanthanides: From Structural and Physico-Chemical Data to Thermodynamic Modeling

International audienc

Speciation in Polynuclear Assemblies with Lanthanides: From Structural and Physico Chemical Data to Thermodynamic Modeling

International audienc

Investigating Reactivity and Interactions in Complex Media: Theoretical and Experimental Approaches

International audienc

Chiral Bambusuril Macrocycles as New Reagents for Tuning Coordination Complexes

International audienc

How to Adapt Scatchard Plot for Graphically Addressing Cooperativity in Multicomponent Self-Assemblies

International audienceA graphical method has been developed for the reliable detection of cooperativity in polymetallic complexes involving intra- and intermolecular complexation processes. The method relies on the determination of the partial occupancy r(AL)n, which represents the average number of metals bound per preassembled receptor AL(n) made up of n ligands bound to a linker A. We observe nonlinear, i.e., nonstatistical, Scatchard-like plots (r(AL)n/[M] vs r(AL)n) for metal-binding in double-stranded helicates. The present concept is extended to a virtual, pre-organized receptor L(n), in which no specific linker is involved. Applications to several polymetallic helicates reveal the presence of negatively cooperative processes attributed mainly to intermetallic repulsions, in agreement with recent thermodynamic models