Adjusted lung injury score by influenza status.

<p>Analyses adjusted for significant covariates (change of risk factor coefficient by ±15%) which included BMI, statin use and daily tidal volume used in addition to age and SOFA score.</p

Treatment variables over the first six days of therapy and outcomes.

<p>All values represent means ± SD unless otherwise specified.</p>1<p><i>p</i>-values based on the following tests: <i>t-</i>test for variables presented as means, Wilcoxon rank-sum test for variables presented as the median, Fisher's exact test of association for categorical variables.</p

ARDS-related pulmonary measures over the first six days of treatment.

<p>All variables [A) PaO₂/FiO₂ ratio; B) positive end expiratory pressure; C) pulmonary compliance; D) lung injury (Murray) score] are recorded from the first complete data point after 8am on each day of observation while on conventional mechanical ventilation. Values from subjects requiring ECMO were dropped on days this modality was utilized. Bars represent box plots for each variable by day and cause of ARDS (H1N1-associated vs non H1N1). Center line represents the median; edges of each box represent the 75^th and 25^th percentiles and whiskers the maximum and minimum values. Dots indicate outliers. (n, for H1N1 associated ARDS is 23, 20, 18, 17, 16 and 14 and non-H1N1 is 30, 33, 34, 30, 29 and 22 for day 0–5).</p

Cohort enrollment diagram.

<p>Cohort enrollment diagram.</p

Unadjusted lung injury score by influenza status.

<p>AUC, area under the curve for first daily lung injury scores.</p