Genome-Wide Association Study in BRCA1 Mutation Carriers Identifies Novel Loci Associated with Breast and Ovarian Cancer Risk

BRCA1-associated breast and ovarian cancer risks can be modified by common genetic variants. To identify further cancer risk-modifying loci, we performed a multi-stage GWAS of 11,705 BRCA1 carriers (of whom 5,920 were diagnosed with breast and 1,839 were diagnosed with ovarian cancer), with a further replication in an additional sample of 2,646 BRCA1 carriers. We identified a novel breast cancer risk modifier locus at 1q32 for BRCA1 carriers (rs2290854, P = 2.7×10-8, HR = 1.14, 95% CI: 1.09-1.20). In addition, we identified two novel ovarian cancer risk modifier loci: 17q21.31 (rs17631303, P = 1.4×10-8, HR = 1.27, 95% CI: 1.17-1.38) and 4q32.3 (rs4691139, P = 3.4×10-8, HR = 1.20, 95% CI: 1.17-1.38). The 4q32.3 locus was not associated with ovarian cancer risk in the general population or BRCA2 carriers, suggesting a BRCA1-specific associat

Letters in a community organisation: a case of powerful literacy Cartas em uma organização comunitária: um caso de letramento poderoso

In this paper I examine discourse in five letters written by executive members of a resident's association in the city of Brasilia, by integrating Critical Discourse Analysis and the New Literacy Studies. These letters were part of a campaign from the association to prevent students of a nearby college from parking their car in the residential street, since the overload of parked cars made difficult the flow of vehicles. A case is made on the efficacy of the discursive and semiotic resources drawn on the letters to have community aims met.<br>Neste trabalho examino o discurso em cinco cartas escritas por membros executivos de uma associação de moradores na cidade de Brasília, por meio da integração entre a Análise de Discurso Crítica e os Novos Estudos do Letramento. Essas cartas fizeram parte de uma campanha da associação para impedir que estudantes de uma faculdade próxima estacionassem seus carros na rua residencial, uma vez que o excesso de veículos estacionados tornava difícil o fluxo de veículos. O argumento é que os recursos discursivos e semióticos utilizados nas cartas são eficazes na satisfação dos objetivos comunitários