Innovation, Managerial Effort, and Start-Up Performance

Managers of start-up firms make a number of important yet understudied decisions, such as whether or not to develop a new product, whether or not to choose a high-technology product or service, whether or not to use external assistance, and the amount of time and effort they will devote to their new company. These choices are informed by their access to various resources, such as the size of the management team, its education level, its previous experience working at start-ups, and other attributes. In this paper we consider how these resources influence optimal provision of effort, and examine decisions about innovative behavior (i.e., to market a novel or high-technology product) and managerial exertion (i.e., the hours per week spent by the managers and their decision to supplement their own efforts by employing external assistance such as consulting services)

The Effectiveness of a Simple Helmholtz coil-like Magnetic Shield at Reducing X-ray-like Background in Space-based X-ray Detectors

Both active and passive magnetic shielding have been used extensively during past and current X-ray astronomy missions to shield detectors from soft protons and electrons entering through telescope optics. However, simulations performed throughout the past decade have discovered that a significant proportion of X-ray-like background originates from secondary electrons produced in spacecraft shielding surrounding X-ray detectors, which hit detectors isotropically from all directions. Here, the results from Geant4 simulations of a simple Helmholtz coil-like magnetic field surrounding a detector are presented, and it is found that a Helmholtz coil-like magnetic field is extremely effective at preventing secondary electrons from reaching the detector. This magnetic shielding method could remove almost all background associated with both backscattering electrons and fully absorbed soft electrons, which together are expected to account for approximately two thirds of the expected off-axis background in silicon-based X-ray detectors of several hundred microns in thickness. The magnetic field structure necessary for doing this could easily be produced using a set of solenoids or neodymium magnets providing that power requirements can be sufficiently optimised or neodymium fluorescence lines can be sufficiently attenuated, respectively.Comment: 20 pages, 6 figure

Speciation in the baboon and its relation to gamma-chain heterogeneity and to the response to induction of HbF by 5-azacytidine

In the baboon (Papio species), the two nonallelic gamma-genes produce gamma-chains that differ at a minimum at residue 75, where isoleucine (I gamma-chain) or valine (V gamma) may be present. This situation obtains in baboons that are sometimes designated as Papio anubis, Papio hamadryas, and Papio papio. However, in Papio cynocephalus, although the I gamma-chains are identical with those in the above mentioned types, the V gamma-chains have the substitutions ala----gly at residue 9 and ala----val at residue 23. The V gamma-chains of P. cynocephalus are called V gamma C to distinguish them from the V gamma A-chains of P. anubis, etc. A single cynocephalus animal has been found to have only normal I gamma-chains and I gamma C-chains (that is, glycine in residue 9, valine in 23, and isoleucine in 75). When HbF is produced in response to stress with 5-azacytidine, P. anubis baboons respond with greater production than do P. cynocephalus, and hybrids fall between. Minimal data on P. hamadryas and P. papio suggest an even lower response than P. cynocephalus. As HbF increases under stress, the ratio of I gamma to V gamma-chains changes from the value in the adult or juvenile baboon toward the ratio in the newborn baboon. However, it does not attain the newborn value. The V gamma A and V gamma C-genes respond differently to stress. In hybrids, the production of V gamma A- chains exceeds that of V gamma C-chains. A controlling factor in cis apparently is present and may be responsible for the species-related extent of total HbF production. It may be concluded that the more primitive the cell in the erythroid maturation series that has been subjected to 5-azacytidine, the more active is the I gamma-gene