Risk factors of multidrug-resistant bacteria in community-acquired urinary tract infections

Background: Urinary tract infections (UTIs) are one of the most seen infection among community. Objectives: In this cross-sectional study we aimed to investigate the risk factors of multidrug-resistant (MDR) bacteria that caused community-acquired UTI (CA-UTI). Methods: Consecutive patients admitted to the Urology and Infectious Diseases policlinics with the diagnosis of CA-UTI were included in the study. A standard form including possible predisposing factors for MDR bacteria was applied. Results: In total, 240 patients (51.3% females) were enrolled in the study. The mean age of participants were 59.8 \ub1 18.3 years old. Escherichia coli (n =166; 69.2%)was the most frequently isolated bacteria and its incidence was higher in females than in males (p=0.01). In total, 129 (53.8%) of the identified pathogens were MDR bacteria. According to multivariate analysis, the use of antibiotics three or more times increased the risk of infection with MDR bacteria by 4.6 times, the history of urinary tract infection in the last 6 months by 2 times, being male and over 65 years old by 3 times. Conclusion: Doctors should consider prescribing broad-spectrum antibiotics in patients with severe UTIs with a history of UTI, advanced age, male gender, and multiple antibiotic usage, even if they have a CA-UTI

Genetic polymorphism in sex hormone metabolism and prostate cancer risk

We compared single-nucleotide polymorphisms for point mutations in cytochrome P450 genes, including cytochrome P450c17 alpha (CYP17), cytochrome P450 aromatase (CYP19), steroid-5-alpha-reductase (SRD5A2), and prostate-specific antigen (PSA) involved in androgen and estrogen production. Between January 2008 and January 2010, 90 patients were enrolled in the study. Of these patients, 28 were diagnosed with benign prostatic hyperplasia and 32 with prostate cancer, while 30 subjects were included as a control group. CYP19 1531 C>T, SRD5A2 gene V89L, CYP17 gene -34 T/C, PSA-158 (G/A) regions were evaluated for the association between polymorphisms and benign prostatic hyperplasia and prostate cancer in study population. Age, body mass index, peak urinary flow rate (Q max), voided urine volume, post-void residual urine volume, total PSA, free PSA, free/total PSA ratio, prostate weights measured by transrectal ultrasonography, erectile dysfunction score, and international prostate symptom score were compared between groups. No statistically significant difference in CYP19 1531 C>T, SRD5A2 V89L, and CYP17 -34T/C was observed in both groups when compared to the control group. The homozygote variant of PSA-158 (G/A) was significantly lower for prostate cancer. Age, total PSA, free PSA, free/total PSA ratio, prostate weight, and Q max were evaluated using multi-variant analysis. Only Q max was significant for the homozygote variant. The probability of being homozygous was 5.8-fold higher in subjects with Q max > 14 mL/s. In the Turkish population, the homozygote variant of PSA-158 (G/A) was significantly lower for prostate cancer

Comparison of Polypropylene Mesh and Primary Repair in the Treatment of Blunt Testicular Rupture

Conclusion: PM grafting is a safe alternative to primary closure of a TA defect following blunt testicular trauma

Perkütan Nefrolitotomi De İki Farklı Renal Dilatasyon Tekniği: One-Shot Dilatasyon ve Ardışık Dilatasyon

Objective: In this study, we aimed to compare the results in patients undergoing the oneshot dilatation (OD) technique and the conventional serial dilatation (SD) technique with amplatz dilators in percutaneous nephrolithotomy (PNL) operations. Methods: We retrospectively evaluated the data of 213 patients who had undergone PNL between January 2016 and June 2018. The patients who had undergone SD were classified as Group 1 and the patients undergoing OD as Group 2. All of the patients had undergone contrast-free computed tomography (CT) before the operation. The PNL procedure was performed by experienced endo-urologists. Follow-up CT was performed in the 3rd postoperative month. The PNL procedure was considered unsuccessful in patients who had a stone larger than 4 mm on the CT scan. The patients were accepted as 'stone free' when there was no residual stone or there was a stone less than 4 mm in diameter on the CT scan. The groups were compared concerning demographic characteristics, operation duration, fluoroscopy duration, amount of hemoglobin change, complication rate (according to the modified Clavien classification), length of hospital stay and the operation success rate. Results: There was no statistically significant difference between the groups concerning operation data, rate of stone-free patients and complication rates. The mean length of hospital stay was shorter in the OD group (p<0.001). Conclusion: The conventional SD procedure is similar to the OD procedure with amplatz dilators concerning the total fluoroscopy time, complication rates and the surgical success rate.Amaç: Perkütan nefrolitotomi operasyonlarında, amplatz dilatatörlerle yapılan one shot dilatasyon tekniği ile konvansiyonel ardışık dilatasyon tekniği uygulanan hastaların sonuçlarını karşılaştırmayı amaçladık. Gereç ve Yöntem: Ocak 2016 ile Haziran 2018 tarihleri arasında perkütan nefrolitotomi operasyonu yapılan 213 hastanın verileri retrospektif olarak değerlendirildi. Ardışık dilatasyon yapılan olgular Grup 1, one shot dilatasyon yapılan olgular ise Grup 2 olarak ayrıldı. Tüm hastalar operasyondan önce kontrastsız bilgisayarlı tomografi ile değerlendirildi. Perkütan nefrolitotomi işlemi deneyimli endourologlar tarafından gerçekleştirildi. Hastalara postoperatif 3. ayda bilgisayarlı tomografi ile kontrol yapıldı. Bilgisayarlı tomografide 4 mm’den büyük taş kalan hastaların perkütan nefrolitotomi işlemi başarısız kabul edildi. Bilgisayarlı tomografi de hiç rezidü olmaması veya 4 mm’den küçük taş varlığı taşsızlık olarak kabul edildi. Gruplar demografik özellikleri, operasyon süresi, skopi süresi hemoglobin değişim miktarı, komplikasyonları (modifiye clavien sınıflaması ile), hastanede kalma süresi ve operasyon başarısı yönünden karşılaştırıldı. Bulgular: Gruplar arasında operasyon verileri, taşsızlık oranları ve komplikasyonlar açısından istatistiksel olarak anlamlı farklılık yoktu. One shot dilatasyon grubunda ortalama hastanede kalış süresi daha kısa olarak tespit edildi (p<0.001). Sonuç: Konvansiyonel ardışık dilatasyon tekniği, toplam floroskopi zamanı, komplikasyon oranları ve cerrahi başarı oranı açısından amplatz dilatörlü one shot dilatasyon tekniğiyle benzerdir

Childhood Enuresis is Associated with Shorter Intravaginal Ejaculatory Latency Time in Healthy Men

Conclusions: We found that intravaginal ejaculatory latency time in men with a history of monosymptomatic enuresis is significantly shorter than that of controls. We have also shown that there is a strong negative correlation between having a history of monosymptomatic enuresis and intravaginal ejaculatory latency time