Exchange of Deuterium Between Methanol and Water: Vibrations of the Hydroxyl Group in Methanol and Methanol‐d: The Entropy of Methanol

New measurements of the equilibrium in the exchange reaction between methanol and heavy water, in conjunction with data in the literature, are considered in relation to the vibrations of the hydroxyl group, including the torsional degree of freedom. An interpretation is presented which allows for a torsional frequency of 250 cm—1, a value which is shown to be in reasonable agreement with the entropy from thermal data.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/70402/2/JCPSA6-6-10-571-1.pd

The Power of Light Zine 2 - Why does life exist? - an epistemically insightful way to explore the nature of science and research at Diamond Light Source, UK

In the STFC funded Epistemic Insight Initiative project, The Power of Light, a series of resources have been designed informed by co-creation activities, pilot lessons, and workshops that involved children in schools and with their families in community spaces. Through this project with Diamond, we brought into classrooms and community spaces how light can be used to help investigate the world around us, address real-world problems and inform our thinking about Big Questions. The resources we develop support teachers' and their students' sense of agency when exploring 'how knowledge works' and how knowledge is built through different disciplines (including the natural sciences, the arts, and the humanities). This 'zine', with its focus on how scientists have been working with paleotonologists to investigate evidence, found inside the fossilised leg of a thescelosaurus, of the cataclysmic event that led to the extinction of dinosaurs. Zine 2 'Why does life exist?' has been developed through co-creative activities involving research scientists at Diamond Light Source (UK), academics, primary school teachers, STEM ambassadors, and Diamond's public engagement team. Zines use an appealing combination of text and images to create a concise comic-like narrative format to generate enthusiasm about a particular area of interest - the series of zines designed for this project focuses on research taking place at the Diamond facility. The Diamond Light Source facility houses a synchrotron which is used to conduct research in a variety of applied fields of science and technology. This zine is designed to be accessible to ages 8+, and works well with a short animation (available in both Zenodo and on the Epistemic Insight You Tube channel) that has been created with additional funding from STFC. Teaching notes are available for this zine, with guidance and activity sheets to support working with the Power of Light resources. This zine explores these discussion questions: 1) What is needed for living things to exist on Earth? 2) What helps us to learn more about past events? 3) What enables us to be able say we 'know' something

The Power of Light Zine 3 - Why do we explore the world around us? - an epistemically insightful way to explore the nature of science and research at Diamond Light Source, UK

In the STFC funded Epistemic Insight Initiative project, The Power of Light, a series of resources have been designed informed by co-creation activities, pilot lessons, and workshops that involved children in schools and with their families in community spaces. Through this project with Diamond, we brought into classrooms and community spaces how light can be used to help investigate the world around us, address real-world problems and inform our thinking about Big Questions. The resources we develop support teachers' and their students' sense of agency when exploring 'how knowledge works' and how knowledge is built through different disciplines (including the natural sciences, the arts, and the humanities). This 'zine', with its focus on how scientists have been working with astronomers, geographers, and other disciplines to explore relationships between matter in environments that we cannot directly experience here on Earth, in space, and into the future through the use of scientific modelling and a synchrotron. Zine 3, with its focus on space and energy, has been developed through co-creative activities involving research scientists at Diamond Light Source (UK), academics, primary school teachers, STEM ambassadors, and Diamond's public engagement team. Zines use an appealing combination of text and images to create a concise comic-like narrative format to generate enthusiasm about a particular area of interest - the series of zines designed for this project focuses on research taking place at the Diamond facility. The Diamond Light Source facility houses a synchrotron which is used to conduct research in a variety of applied fields of science and technology. This zine is designed to be accessible to ages 8+, and works well with a short animation (available in both Zenodo and on the Epistemic Insight You Tube channel) that has been created with additional funding from STFC. Teaching notes are available for this zine, with guidance and activity sheets to support working with the Power of Light resources. This zine explores these discussion questions: 1) What do we know bout our planet Earth (and how it 'works')? 2) What can help us build knowledge about things beyond planet Earth? 3) What might help to inform our thinking when making choices and decisions

The Power of Light Zine 1 - Why do things change? - an epistemically insightful way to explore the nature of science and research at Diamond Light Source, UK

In the STFC funded Epistemic Insight Initiative project, The Power of Light, a series of resources have been designed informed by co-creation activities, pilot lessons, and workshops that involved children in schools and with their families in community spaces. Through this project with Diamond, we brought into classrooms and community spaces how light can be used to help investigate the world around us, address real-world problems and inform our thinking about Big Questions. The resources we develop support teachers' and their students' sense of agency when exploring 'how knowledge works' and how knowledge is built through different disciplines (including the natural sciences, the arts, and the humanities). This 'zine', with its focus on how scientists have been working with historians and archaeologists to preserve the Mary Rose (Henry the Eighth's favourite ship that was sunk in the Solent in England's southern coast), has been developed through co-creative activities involving research scientists at Diamond Light Source (UK), academics, primary school teachers, STEM ambassadors, and Diamond's public engagement team. Zines use an appealing combination of text and images to create a concise comic-like narrative format to generate enthusiasm about a particular area of interest - the series of zines designed for this project focuses on research taking place at the Diamond facility. The Diamond Light Source facility houses a synchrotron which is used to conduct research in a variety of applied fields of science and technology. This zine is designed to be accessible to ages 8+, and works well with a short animation (available in both Zenodo and on the Epistemic Insight You Tube channel) that has been created with additional funding from STFC. Teaching notes are available for this zine, with guidance and activity sheets to support working with the Power of Light resources. This zine explores these discussion questions: 1) What are examples of changes we can observe? 2) What helps us to know more about the things around us? 3) What might we use to help us observe changes

New first integral for twisting type-N vacuum gravitational fields with two non-commuting Killing vectors

A new first integral for the equations corresponding to twisting type-N vacuum gravitational fields with two non-commuting Killing vectors is introduced. A new reduction of the problem to a complex second-order ordinary differential equation is given. Alternatively, the mentioned first integral can be used in order to provide a first integral of the second-order complex equation introduced in a previous treatment of the problem.Comment: 7 pages, LaTeX, uses ioplppt.sty and iopl12.sty; to be published in Class. Quantum Gra

The Wnt receptor Ryk is required for Wnt5a-mediated axon guidance on the contralateral side of the corpus callosum

Ryk (receptor related to tyrosine kinase) has been shown to be a novel Wnt receptor in both Caenorhabditis elegans and Drosophila melanogaster. Recently, Ryk-Wnt interactions were shown to guide corticospinal axons down the embryonic mouse spinal cord. Here we show that, in Ryk-deficient mice, cortical axons project aberrantly across the major forebrain commissure, the corpus callosum. Many mouse mutants have been described in which loss-of-function mutations result in the inability of callosal axons to cross the midline, thereby forming Probst bundles on the ipsilateral side. In contrast, loss of Ryk does not interfere with the ability of callosal axons to cross the midline but impedes their escape from the midline into the contralateral side. Therefore, Ryk(-/-) mice display a novel callosal guidance phenotype. We also show that Wnt5a acts as a chemorepulsive ligand for Ryk, driving callosal axons toward the contralateral hemisphere after crossing the midline. In addition, whereas callosal axons do cross the midline in Ryk(-/-) embryos, they are defasciculated on the ipsilateral side, indicating that Ryk also promotes fasciculation of axons before midline crossing. In summary, this study expands the emerging role for Wnts in axon guidance and identifies Ryk as a key guidance receptor in the establishment of the corpus callosum. Our analysis of Ryk function further advances our understanding of the molecular mechanisms underlying the formation of this important commissure

Investigating energetic electron precipitation through combining ground-based and balloon observations

A detailed comparison is undertaken of the energetic electron spectra and fluxes of two precipitation events that were observed in 18/19 January 2013. A novel but powerful technique of combining simultaneous ground-based subionospheric radio wave data and riometer absorption measurements with X-ray fluxes from a Balloon Array for Relativistic Radiation-belt Electron Losses (BARREL) balloon is used for the first time as an example of the analysis procedure. The two precipitation events are observed by all three instruments, and the relative timing is used to provide information/insight into the spatial extent and evolution of the precipitation regions. The two regions were found to be moving westward with drift periods of 5–11 h and with longitudinal dimensions of ~20° and ~70° (1.5–3.5 h of magnetic local time). The electron precipitation spectra during the events can be best represented by a peaked energy spectrum, with the peak in flux occurring at ~1–1.2 MeV. This suggests that the radiation belt loss mechanism occurring is an energy-selective process, rather than one that precipitates the ambient trapped population. The motion, size, and energy spectra of the patches are consistent with electromagnetic ion cyclotron-induced electron precipitation driven by injected 10–100 keV protons. Radio wave modeling calculations applying the balloon-based fluxes were used for the first time and successfully reproduced the ground-based subionospheric radio wave and riometer observations, thus finding strong agreement between the observations and the BARREL measurements

The impact of hyperhidrosis on patients' daily life and quality of life : A qualitative investigation

Background: An understanding of the daily life impacts of hyperhidrosis and how patients deal with them, based on qualitative research, is lacking. This study investigated the impact of hyperhidrosis on the daily life of patients using a mix of qualitative research methods. Methods: Participants were recruited through hyperhidrosis patient support groups such as the Hyperhidrosis Support Group UK. Data were collected using focus groups, interviews and online surveys. A grounded theory approach was used in the analysis of data transcripts. Data were collected from 71 participants, out of an initial 100 individuals recruited. Results: Seventeen major themes capturing the impacts of hyperhidrosis were identified; these covered all areas of life including daily life, psychological well-being, social life, professional /school life, dealing with hyperhidrosis, unmet health care needs and physical impact. Conclusions: Psychosocial impacts are central to the overall impacts of hyperhidrosis, cutting across and underlying the limitations experienced in other areas of life.Peer reviewe