The Maine Annex, vol. 1, no. 12

The Maine Annex, published by the students of the University of Maine at the Brunswick Campus, was launched January 10, 1947. Editors introduced the publication as the product of a group of progressive students attending the Brunswick Campus. The goal of the publication, according to editors, was to tell the story of our life on this campus. The four-page, tabloid-sized paper included display advertising from area businesses. This issue contains an editorial lamenting the presence of State Police Officers at the Victory Dance the previous weekend. In addition to approximately 250 women bussed in from surrounding communities, blue uniformed proponents of the law were thicker than ants at a picnic

The Maine Annex, vol. 1, no. 13

The Maine Annex, published by the students of the University of Maine at the Brunswick Campus, was launched January 10, 1947. Editors introduced the publication as the product of a group of progressive students attending the Brunswick Campus. The goal of the publication, according to editors, was to tell the story of our life on this campus. The four-page, tabloid-sized paper included display advertising from area businesses. Amid the coverage in this issue is a retrospective piece discussing the Brunswick Annex campus at Brunswick Naval Air Base

The Maine Annex, vol. 1, no. 11

The Maine Annex, published by the students of the University of Maine at the Brunswick Campus, was launched January 10, 1947. Editors introduced the publication as the product of a group of progressive students attending the Brunswick Campus. The goal of the publication, according to editors, was to tell the story of our life on this campus. The four-page, tabloid-sized paper included display advertising from area businesses. Following World War II, the federal G.I. Bill enabled approximately 2.3 million, predominantly white male Veterans to receive a post-secondary education. To accommodate increased enrollment, in 1946 the University of Maine established the Brunswick Campus at the former Brunswick Naval Air Station. The remote campus operated until spring 1949, when Veteran registrations waned. Page two discussions in this issue orbit the issue of G.I. Subsistence, from James McNiff\u27s article examining the discrepancy between the increased cost of living in the U.S. and the inadequate amount of money allocated through the Veterans subsistence allowance to commentary about the persistently, poor quality of food provided to students by the University in exchange for their money

The Maine Annex, vol. 1, no. 10

The Maine Annex, published by the students of the University of Maine at the Brunswick Campus, was launched January 10, 1947. Editors introduced the publication as the product of a group of progressive students attending the Brunswick Campus. The goal of the publication, according to editors, was to tell the story of our life on this campus. The four-page, tabloid-sized paper included display advertising from area businesses. The start of a funding drive to build the Memorial Union on the University of Maine, Orono campus, is covered in this issue of The Maine Annex. The Union is to be dedicated to 175 UMaine Alumni war dead. Following World War II, the federal G.I. Bill enabled approximately 2.3 million, predominantly white male Veterans to receive a post-secondary education. To accommodate increased enrollment, in 1946 the University of Maine established the Brunswick Campus at the former Brunswick Naval Air Station. The remote campus operated until spring 1949, when Veteran registrations waned

Inhibitory Role of Notch1 in Calcific Aortic Valve Disease

Aortic valve calcification is the most common form of valvular heart disease, but the mechanisms of calcific aortic valve disease (CAVD) are unknown. NOTCH1 mutations are associated with aortic valve malformations and adult-onset calcification in families with inherited disease. The Notch signaling pathway is critical for multiple cell differentiation processes, but its role in the development of CAVD is not well understood. The aim of this study was to investigate the molecular changes that occur with inhibition of Notch signaling in the aortic valve. Notch signaling pathway members are expressed in adult aortic valve cusps, and examination of diseased human aortic valves revealed decreased expression of NOTCH1 in areas of calcium deposition. To identify downstream mediators of Notch1, we examined gene expression changes that occur with chemical inhibition of Notch signaling in rat aortic valve interstitial cells (AVICs). We found significant downregulation of Sox9 along with several cartilage-specific genes that were direct targets of the transcription factor, Sox9. Loss of Sox9 expression has been published to be associated with aortic valve calcification. Utilizing an in vitro porcine aortic valve calcification model system, inhibition of Notch activity resulted in accelerated calcification while stimulation of Notch signaling attenuated the calcific process. Finally, the addition of Sox9 was able to prevent the calcification of porcine AVICs that occurs with Notch inhibition. In conclusion, loss of Notch signaling contributes to aortic valve calcification via a Sox9-dependent mechanism

The Maine Annex, vol. 1, no. 11

The Maine Annex, published by the students of the University of Maine at the Brunswick Campus, was launched January 10, 1947. Editors introduced the publication as the product of a group of progressive students attending the Brunswick Campus. The goal of the publication, according to editors, was to tell the story of our life on this campus. The four-page, tabloid-sized paper included display advertising from area businesses. Following World War II, the federal G.I. Bill enabled approximately 2.3 million, predominantly white male Veterans to receive a post-secondary education. To accommodate increased enrollment, in 1946 the University of Maine established the Brunswick Campus at the former Brunswick Naval Air Station. The remote campus operated until spring 1949, when Veteran registrations waned. Page two discussions in this issue orbit the issue of G.I. Subsistence, from James McNiff\u27s article examining the discrepancy between the increased cost of living in the U.S. and the inadequate amount of money allocated through the Veterans subsistence allowance to commentary about the persistently, poor quality of food provided to students by the University in exchange for their money