‘We were very much surprised at their worship’: American Girls and Religious Tourism in the Early Republic, 1780-1835

Following the Revolution, the United States formally embraced the ideal and practice of religious freedom. But how was this ideal instilled and practiced? Could a form of pilgrimage have been mobilised in order to inculcate it? In this article I argue that in the early American republic, religious freedom was demonstrated and imparted to adolescents through a unique form of pilgrimage: visiting and attending the worship services of religious minorities while on tour. I demonstrate my argument by considering the travel accounts of fifteen, Protestant, American adolescent girls (aged 10 to 21) between 1782 and 1835; I trace their visits to various houses of worship while on tour and discuss their experiences. Scattered amid their descriptions are reports of attendance at the religious services of other faiths and other Christian denominations and sects. By stopping to encounter members of these religious minorities and to attend their religious worship along the tour, parents may have sought to demonstrate that enjoying civil privileges was no longer a product of one’s religious affiliation or beliefs, but rather the outcome of one’s shared national belonging and solidarity. This article both highlights the connections between forms of youth tourism and religious tolerance, and contributes to the scholarship concerning citizenship formation during the formative years of the modern state in the late eighteenth and early nineteenth centuries

ALTERNATIVE METHODS OF DESALINATION FOR SUB-SAHARAN AFRICA: A REVIEW OF PREFILTRATION AND MICROBIAL DESALINATION CELL TECHNOLOGY

Gemstone Team NOSALTOur research project has addressed the global need for greater accessibility to potable drinking water, specifically within the regions of sub-Saharan Africa. Initially, we planned to design a unique desalination system that was composed of a pre-filtration unit, a microbial desalination cell (MDC) and a post-desalination treatment unit. When in-person lab work was no longer feasible due to COVID-19 guidelines, we refocused our project to review the construction, efficiency, and cost effectiveness of the different designs of potential prefiltration units and MDC configurations. Our review of potential prefiltration systems included both chemical and physical separation methods, and the review of the MDC included the air cathode, biocathode and stacked configurations. While researching the technical details of the prefiltration and MDC systems, we also considered the cultural and societal impacts of introducing a technology such as the MDC into our project region. Our project started as an analysis of an emerging technology, but as the team has grown, the project has transformed into a comprehensive review of the emerging microbial desalination technology and the societal impacts of implementing it into some of the water scarce regions of coastal sub-Saharan Africa

Cognitive Flexibility Predicts PTSD Symptoms: Observational and Interventional Studies

Introduction: Post-Traumatic Stress Disorder (PTSD) is a prevalent, severe and tenacious psychopathological consequence of traumatic events. Neurobehavioral mechanisms underlying PTSD pathogenesis have been identified, and may serve as risk-resilience factors during the early aftermath of trauma exposure. Longitudinally documenting the neurobehavioral dimensions of early responses to trauma may help characterize survivors at risk and inform mechanism-based interventions. We present two independent longitudinal studies that repeatedly probed clinical symptoms and neurocognitive domains in recent trauma survivors. We hypothesized that better neurocognitive functioning shortly after trauma will be associated with less severe PTSD symptoms a year later, and that an early neurocognitive intervention will improve cognitive functioning and reduce PTSD symptoms.Methods: Participants in both studies were adult survivors of traumatic events admitted to two general hospitals’ emergency departments (EDs) in Israel. The studies used identical clinical and neurocognitive tools, which included assessment of PTSD symptoms and diagnosis, and a battery of neurocognitive tests. The first study evaluated 181 trauma-exposed individuals one-, six-, and 14 months following trauma exposure. The second study evaluated 97 trauma survivors 1 month after trauma exposure, randomly allocated to 30 days of web-based neurocognitive intervention (n = 50) or control tasks (n = 47), and re-evaluated all subjects three- and 6 months after trauma exposure.Results: In the first study, individuals with better cognitive flexibility at 1 month post-trauma showed significantly less severe PTSD symptoms after 13 months (p = 0.002). In the second study, the neurocognitive training group showed more improvement in cognitive flexibility post-intervention (p = 0.019), and lower PTSD symptoms 6 months post-trauma (p = 0.017), compared with controls. Intervention- induced improvement in cognitive flexibility positively correlated with clinical improvement (p = 0.002).Discussion: Cognitive flexibility, shortly after trauma exposure, emerged as a significant predictor of PTSD symptom severity. It was also ameliorated by a neurocognitive intervention and associated with a better treatment outcome. These findings support further research into the implementation of mechanism-driven neurocognitive preventive interventions for PTSD

"Oh, how sweet was the scene": American Girls, Travel and the Hudson River Valley in the Early Republic

Avant la deuxième décennie du dix-neuvième siècle, la Vallée de l'Hudson était devenue à la fois une destination touristique, réputée pour sa beauté naturelle, et le lieu de transformations commerciales et industrielles significatives. Les voyageurs qui venaient dans la vallée avaient sans cesse exprimé leurs réactions devant ce paysage emblématique, mais les expériences de voyages des enfants et des adolescents ont été systématiquement absentes des études sur la littérature de voyage. Dans cet article, j'étudie les expériences des jeunes filles en voyage, à travers la lecture des récits de voyage de quatorze jeunes Américaines blanches, issues des classes moyenne et moyenne supérieure (âgées de 10 à 21 ans), qui ont écrit sur leur voyage dans la vallée entre 1758 et 1840. J'examine leurs réactions au milieu social et à l'environnement géographique de l'Hudson. Je défends l'idée que ces voyages ont à la fois initié ces jeunes filles au milieu social américain et leur ont fait faire connaissance avec le paysage historique et géographique de leur nation, favorisant par là la formation d'un sentiment nouveau d'identité nationale partagée

Real-Life Experience and Diagnostic Utility of the BioFire Joint Infection PCR Panel in Bone and Joint Infections: Analysis of a Prospective Validation Study

Abstract Introduction Microbiological diagnosis is central for adequate treatment of bone and joint infections. Culture-based methods have a limited diagnostic sensitivity and a long turnaround time (TAT). The objective of this study was to compare the diagnostic performance of BioFire Joint Infection Panel Investigational Use Only version (hereafter BioFire)—a sample-to-result multiplex PCR panel—with culture-based methods and 16S ribosomal RNA (rRNA) PCR and sequencing, when available. Methods This study presents a retrospective analysis of a prospective validation study of the BioFire panel. Specimens were obtained from consecutive patients evaluated for suspected bone and joint infections and processed using culture, BioFire, and 16S rRNA PCR and sequencing. Final clinical diagnosis was used as the reference for definition of infection. Results Samples, including synovial fluid, bone and periarticular tissue, were obtained from 57 patients, 39 of whom were finally diagnosed with a bone or joint infection. Cultures were positive in 27/39 infected patients and in 3/18 uninfected patients (sensitivity 69%, specificity 83%). BioFire was positive in 22/39 infected patients and in none of the uninfected patients (sensitivity 56%, specificity 100%). Sensitivity for PCR panel organisms was 92% (22/24) and sensitivity for organisms identified by any microbiological modality was 69% (22/32). Gram stain results were positive in 13/39 infected patients and in none of the uninfected patients (sensitivity 33%, specificity 100%). 16S rRNA was positive in 20/28 infected patients and in 0/12 uninfected patients (sensitivity 71%, specificity 100%). Net machine time for BioFire—1 h—was shorter than the mean TAT for Gram stain results, which was 4 h. Conclusion BioFire offered equivalent diagnostic performance with superior TAT for bone and joint infections, compared with conventional methods

Cleft Lip and/or Cleft Palate: Prenatal Accuracy, Postnatal Course, and Long-Term Outcomes

Orofacial clefts include cleft lip (CL) and cleft palate (CP). This retrospective study assessed the efficacy of prenatal sonographic diagnosis of isolated and non-isolated cases of CL/CP and the postnatal outcomes of these children. Data regarding patients diagnosed and treated in the tertiary orofacial clinic from 2000 to 2020 were retrieved from electronic medical records and telephone-based questionnaires. Isolated CL was found in 7 cases (7.2%), isolated CP in 51 (53%), and combined CL/CP in 38 (39.5%), and 22 cases (23%) were associated with other anomalies. Among 96 cases, 39 (40.6%) were diagnosed prenatally. Isolated CL was diagnosed in 5/7 (71.5%), combined clefts in 29/38 (76.3%), and CP in 7/51 (13.8%). Prenatal chromosomal analysis performed in 32/39 (82%) cases was normal for all. The rate of surgical intervention in the first year of life was 36/38 (94.7%) for combined clefts, 5/7 (71.4%) for CL, and 20/51 (39%) for isolated CP. Most children had speech therapy (23/38 (60.5%), 3/7 (42.8%), and 41/51 (80.3%), respectively) and psychotherapy (6/38 (15.7%), 3/7 (42.8%) and, 15/51 (29.4%), respectively). The accuracy rate of sonographic prenatal diagnosis is low. Our results emphasize the suggested work-up of fetuses with CL and/or CP and improvements to parental counseling, as well as their understanding and compliance regarding post-natal therapeutic plans