Native American Weight Loss Movement: Pilot Test of a Culturally Tailored Weight Loss Program for American Indians

American Indians (AIs) have higher rates of obesity than other racial/ethnic groups, placing them at heightened risk for cardiovascular diseases, diabetes, and certain cancers. Culturally appropriate weight loss interventions may be the key to reducing risk. The most successful program used in AI communities has been the Diabetes Prevention Program (DPP), which limits enrollment to individuals with a clinical diagnosis of pre-diabetes. The purpose of this pilot project was to modify and culturally tailor a weight loss intervention to AI communities in Kansas to improve weight loss related behaviors among those who do not qualify for the DPP. The Native American Weight Loss Movement (NAWLM) was developed from 2012-2014 using an iterative process with 4 sequential modifications to the program. Group 1 received a slightly modified version of the DPP that was originally tailored to African Americans. Each group received an improved program based on modifications from the previous group. Our analysis shows 36.1% (95% CI: 25.7, 47.5) of all participants (n=72) lost weight; a majority (63.9%, 95% CI: 52.8-75.0) maintained weight, gained weight, or dropped out. Among individuals who completed the program (n=34), 76.5% lost weight (95% CI: 61.4, 91.5). These individuals lost an average of 2.98% body weight (95% CI: 1.58, 4.37), with 6 participants losing \u3e7% body weight. While most participants who completed the program lost weight, more research is needed to determine factors that discourage drop-out and promote behavioral changes. NAWLM shows promise as a weight loss program for AIs who do not qualify for the DPP

Internet All Nation Breath of life (I-ANBL) a Tribal College Student Engaged Development of an Internet-based Smoking Cessation Intervention

Background: Compared to non-Hispanic white college students, American Indian (AI) tribal college students have the highest smoking prevalence in the U.S. (~34%). Culturally-tailored smoking cessation programs have proven to be successful in reducing smoking rates but may require new methods to reach college students. Currently, there is little documentation on the development and success of Internet-based smoking interventions for AI tribal college students. Objectives: To develop an Internet-based smoking cessation program (Internet-All Nations Breath of Life or I-ANBL) with tribal college students. Methods: We conducted six focus groups (n=41) at a tribal college. Focus groups included tribal college students who smoked and groups were stratified by sex. Transcripts were analyzed using insider and outsider perspectives. After analysis, an Internet-based smoking cessation program was developed, based on insight gained. Results: Numerous suggestions for creating the program were offered. There was consensus on the need for a variety of visuals including cultural images, videos, and interactive content. The students also suggested the integration of familiar platforms such as FacebookTM. Conclusion: When culturally tailoring a web-based smoking cessation program for tribal college students, it is important to incorporate cultural aspects and recognize gender differences. One important aspect is to recognize that for many AI, tobacco is a sacred plant and images of tobacco should be respectful. Now that this intervention has been developed, next we will test it for efficacy in a randomized controlled trial. Keywords: American Indians, tribal college, tobacco, program development, smoking cessation, community-based participatory researc

WIRC+Pol: A Low-resolution Near-infrared Spectropolarimeter

WIRC+Pol is a newly commissioned low-resolution (R ~ 100), near-infrared (J and H bands) spectropolarimetry mode of the Wide-field InfraRed Camera (WIRC) on the 200 inch Hale Telescope at Palomar Observatory. The instrument utilizes a novel polarimeter design based on a quarter-wave plate and a polarization grating (PG), which provides full linear polarization measurements (Stokes I, Q, and U) in one exposure. The PG also has high transmission across the J and H bands. The instrument is situated at the prime focus of an equatorially mounted telescope. As a result, the system only has one reflection in the light path providing minimal telescope induced polarization. A data reduction pipeline has been developed for WIRC+Pol to produce linear polarization measurements from observations. WIRC+Pol has been on-sky since 2017 February. Results from the first year commissioning data show that the instrument has a high dispersion efficiency as expected from the polarization grating. We demonstrate the polarimetric stability of the instrument with rms variation at 0.2% level over 30 minutes for a bright standard star (J = 8.7). While the spectral extraction is photon noise limited, polarization calibration between sources remain limited by systematics, likely related to gravity dependent pointing effects. We discuss instrumental systematics we have uncovered in the data, their potential causes, along with calibrations that are necessary to eliminate them. We describe a modulator upgrade that will eliminate the slowly varying systematics and provide polarimetric accuracy better than 0.1%

The Rossiter-McLaughlin effect in Exoplanet Research

The Rossiter-McLaughlin effect occurs during a planet's transit. It provides the main means of measuring the sky-projected spin-orbit angle between a planet's orbital plane, and its host star's equatorial plane. Observing the Rossiter-McLaughlin effect is now a near routine procedure. It is an important element in the orbital characterisation of transiting exoplanets. Measurements of the spin-orbit angle have revealed a surprising diversity, far from the placid, Kantian and Laplacian ideals, whereby planets form, and remain, on orbital planes coincident with their star's equator. This chapter will review a short history of the Rossiter-McLaughlin effect, how it is modelled, and will summarise the current state of the field before describing other uses for a spectroscopic transit, and alternative methods of measuring the spin-orbit angle.Comment: Review to appear as a chapter in the "Handbook of Exoplanets", ed. H. Deeg & J.A. Belmont

WIRC+Pol: A Low-resolution Near-infrared Spectropolarimeter

WIRC+Pol is a newly commissioned low-resolution (R ~ 100), near-infrared (J and H bands) spectropolarimetry mode of the Wide-field InfraRed Camera (WIRC) on the 200 inch Hale Telescope at Palomar Observatory. The instrument utilizes a novel polarimeter design based on a quarter-wave plate and a polarization grating (PG), which provides full linear polarization measurements (Stokes I, Q, and U) in one exposure. The PG also has high transmission across the J and H bands. The instrument is situated at the prime focus of an equatorially mounted telescope. As a result, the system only has one reflection in the light path providing minimal telescope induced polarization. A data reduction pipeline has been developed for WIRC+Pol to produce linear polarization measurements from observations. WIRC+Pol has been on-sky since 2017 February. Results from the first year commissioning data show that the instrument has a high dispersion efficiency as expected from the polarization grating. We demonstrate the polarimetric stability of the instrument with rms variation at 0.2% level over 30 minutes for a bright standard star (J = 8.7). While the spectral extraction is photon noise limited, polarization calibration between sources remain limited by systematics, likely related to gravity dependent pointing effects. We discuss instrumental systematics we have uncovered in the data, their potential causes, along with calibrations that are necessary to eliminate them. We describe a modulator upgrade that will eliminate the slowly varying systematics and provide polarimetric accuracy better than 0.1%

The Characterization of Twenty Sequenced Human Genomes

We present the analysis of twenty human genomes to evaluate the prospects for identifying rare functional variants that contribute to a phenotype of interest. We sequenced at high coverage ten “case” genomes from individuals with severe hemophilia A and ten “control” genomes. We summarize the number of genetic variants emerging from a study of this magnitude, and provide a proof of concept for the identification of rare and highly-penetrant functional variants by confirming that the cause of hemophilia A is easily recognizable in this data set. We also show that the number of novel single nucleotide variants (SNVs) discovered per genome seems to stabilize at about 144,000 new variants per genome, after the first 15 individuals have been sequenced. Finally, we find that, on average, each genome carries 165 homozygous protein-truncating or stop loss variants in genes representing a diverse set of pathways

The Zwicky Transient Facility: Science Objectives

The Zwicky Transient Facility (ZTF), a public–private enterprise, is a new time-domain survey employing a dedicated camera on the Palomar 48-inch Schmidt telescope with a 47 deg2 field of view and an 8 second readout time. It is well positioned in the development of time-domain astronomy, offering operations at 10% of the scale and style of the Large Synoptic Survey Telescope (LSST) with a single 1-m class survey telescope. The public surveys will cover the observable northern sky every three nights in g and r filters and the visible Galactic plane every night in g and r. Alerts generated by these surveys are sent in real time to brokers. A consortium of universities that provided funding (“partnership”) are undertaking several boutique surveys. The combination of these surveys producing one million alerts per night allows for exploration of transient and variable astrophysical phenomena brighter than r∼20.5 on timescales of minutes to years. We describe the primary science objectives driving ZTF, including the physics of supernovae and relativistic explosions, multi-messenger astrophysics, supernova cosmology, active galactic nuclei, and tidal disruption events, stellar variability, and solar system objects. © 2019. The Astronomical Society of the Pacific

Aperture Photometry Tool Versus SExtractor for Noncrowded Fields

Outputs from new software program Aperture Photometry Tool (APT) are compared with similar outputs from SExtractor for sources extracted from R-band optical images acquired by the Palomar Transient Factory (PTF), infrared mosaics constructed from Spitzer Space Telescope images, and a processed visible/near-infrared image from the Hubble Legacy Archive (HLA). Two large samples from the PTF images are studied, each containing around 3 × 10^3 sources from noncrowded fields. The median values of source-intensity relative percentage differences between the two software programs, computed separately for two PTF samples, are +0.13% and +0.17%, with corresponding statistical dispersions of 1.43% and 1.84%, respectively. For the Spitzer mosaics, a similar large sample of extracted sources for each of channels 1–4 of Spitzer’s Infrared Array Camera (IRAC) are analyzed with two different sky annulus sizes, and we find that the median and modal values of source-intensity relative percentage differences between the two software programs are between -0.5% and +2.0%, and the corresponding statistical dispersions range from 1.4 to 6.7%, depending on the Spitzer IRAC channel and sky annulus. The results for the HLA image are mixed, as might be expected for a moderately crowded field. The comparisons for the three different kinds of images show that there is generally excellent agreement between APT and SExtractor. Differences in source-intensity uncertainty estimates for the PTF images amount to less than 3% for the PTF sources, and these are potentially caused by SExtractor’s omission of the sky background uncertainty term in the formula for source-intensity uncertainty, as well as differing methods of sky background estimation