The Correlation Between Gabriel Method Usage and Students' Reading Al-Qur'an Ability in TPQ Raudlatul Qur'an Arosbaya Bangakalan

Penelitian ini bertujuan untuk mengungkap masalah pengaruh metode Gabriel terhadap kemampuan membaca Al-Qur'an siswa TPQ Raudlatul Qur'an Karang Duwak, Arosbaya. Jenis penelitian ini adalah penelitian kuantitatif dengan pendekatan korelasional dan populasi dalam penelitian ini adalah seluruh siswa TPQ Raudlatul Qur'an yang berjumlah 33 siswa. Metode pengumpulan data yang digunakan adalah observasi, angket, wawancara dan dokumentasi skala pengukuran menggunakan Likert, analisis data dengan teknik editing dan tabulasi. Dari penelitian yang dilakukan disimpulkan bahwa pengaruh metode Gabriel terhadap kemampuan membaca Alquran siswa di TPQ Raudlatul Qur'an adalah 89,3%, artinya penerapan Metode Gabriel di TPQ Raudlatul Qur'an Karang Duwek Arosbaya berhasilkarenamemiliki pengaruh yang besar terhadap kemampuan membaca Al-Qur'an siswa. This study aims to reveal the problem of the correlationof Gabriel method of reading Qur'an ability on TPQ Raudlatul Qur'an students Karang Duwak, Arosbaya. The type of the research is quantitative research using a correlation approach and the population in this study was all students of TPQ Raudlatul Qur'an totally 33 students. The data collection method used were observation, questionnaires, interviews and documentation of the measurement scale using Likert, the data analysis was editing and tabulation techniques. From the research conducted, it was concluded that the correlationof the Gabriel method on the students reading Qur'an ability in TPQ Raudlatul Qur'an was 89.3%, it means that Gabriel Method application in TPQ Raudlatul Qur'an Karang Duwek Arosbaya was successful, considering the method had big influence on the students' ability in reading Qur'an

Controlled-release formulation of antihistamine based on cetirizine zinc-layered hydroxide nanocomposites and its effect on histamine release from basophilic leukemia (RBL-2H3) cells

Samer Hasan Hussein Al Ali,1 Mothanna Al-Qubaisi,2 Mohd Zobir Hussein,1,3 Maznah Ismail,2,4 Zulkarnain Zainal,1 Muhammad Nazrul Hakim51Department of Chemistry, Faculty of Science, 2Laboratory of Molecular Biomedicine, Institute of Bioscience, 3Advanced Materials and Nanotechnology Laboratory, Institute of Advanced Technology (ITMA), 4Department of Nutrition and Dietetics, Faculty of Medicine and Health Science, Universiti Putra, Malaysia; 5Department of Biomedical Science, Faculty of Medicine and Health Science, Universiti Putra Malaysia, Selangor, MalaysiaAbstract: A controlled-release formulation of an antihistamine, cetirizine, was synthesized using zinc-layered hydroxide as the host and cetirizine as the guest. The resulting well-ordered nanolayered structure, a cetirizine nanocomposite "CETN," had a basal spacing of 33.9 Å, averaged from six harmonics observed from X-ray diffraction. The guest, cetirizine, was arranged in a horizontal bilayer between the zinc-layered hydroxide (ZLH) inorganic interlayers. Fourier transform infrared spectroscopy studies indicated that the intercalation takes place without major change in the structure of the guest and that the thermal stability of the guest in the nanocomposites is markedly enhanced. The loading of the guest in the nanocomposites was estimated to be about 49.4% (w/w). The release study showed that about 96% of the guest could be released in 80 hours by phosphate buffer solution at pH 7.4 compared with about 97% in 73 hours at pH 4.8. It was found that release was governed by pseudo-second order kinetics. Release of histamine from rat basophilic leukemia cells was found to be more sensitive to the intercalated cetirizine in the CETN compared with its free counterpart, with inhibition of 56% and 29%, respectively, at 62.5 ng/mL. The cytotoxicity assay toward Chang liver cells line show the IC50 for CETN and ZLH are 617 and 670 µg/mL, respectively.Keywords: cetirizine hydrochloric acid, nanocomposite, zinc-layered hydroxide, histamine release, rat basophilic leukemia (RBL-2H3) cell

Comparative study of Mg/Al- and Zn/Al-layered double hydroxide-perindopril erbumine nanocomposites for inhibition of angiotensin-converting enzyme

Samer Hasan Hussein Al Ali,1 Mothanna Al-Qubaisi,2 Mohd Zobir Hussein,1,3 Maznah Ismail,2,4 Zulkarnain Zainal,1 Muhammad Nazrul Hakim51Department of Chemistry, Faculty of Science, 2Laboratory of Molecular Biomedicine, Institute of Bioscience, 3Advanced Materials and Nanotechnology Laboratory, Institute of Advanced Technology, 4Department of Nutrition and Health Science, 5Department of Biomedical Science, Faculty of Medicine and Health Science, Universiti Putra Malaysia, Selangor, MalaysiaAbstract: The intercalation of a drug active, perindopril, into Mg/Al-layered double hydroxide for the formation of a new nanocomposite, PMAE, was accomplished using a simple ion exchange technique. A relatively high loading percentage of perindopril of about 36.5% (w/w) indicates that intercalation of the active took place in the Mg/Al inorganic interlayer. Intercalation was further supported by Fourier transform infrared spectroscopy, and thermal analysis shows markedly enhanced thermal stability of the active. The release of perindopril from the nanocomposite occurred in a controlled manner governed by pseudo-second order kinetics. MTT assay showed no cytotoxicity effects from either Mg/Al-layered double hydroxide or its nanocomposite, PMAE. Mg/Al-layered double hydroxide showed angiotensin-converting enzyme inhibitory activity, with 5.6% inhibition after 90 minutes of incubation. On incubation of angiotensin-converting enzyme with 0.5 µg/mL of the PMAE nanocomposite, inhibition of the enzyme increased from 56.6% to 70.6% at 30 and 90 minutes, respectively. These results are comparable with data reported in the literature for Zn/Al-perindopril.Keywords: magnesium, aluminum, layered double hydroxide, perindopril erbumine, ion exchange, angiotensin-converting enzyme, Chang cells lin

Penyuluhan Masyarakat dalam Menumbuhkan Kesadaran Melestarikan Tradisi Sabellesen di Desa Cok-Pocok Daleman Kecamatan Galis Kabupaten Bangkalan

Sabellesen  merupakan sebuah  istilah yang diaplikasikan sebagai nama sebuah tradisi di kampung Cok-Pocok Daleman Galis. Tradisi ini biasanya direalisasikan pada setiap tanggal 11 bulan Hijriyah (bulen Madureh) yang esensinya berupa amalan bersalawat kepada Nabi, berzikir terhadap Allah, sadaqah yang dapat mempererat hubungan tali silaturahmi antar masyarakat. Terlepas dari itu, tradisi Sabellesen juga sebagai wadah bagi masyarakat, khususnya kampung Cok-Pocok Daleman sebagai kegiatan pencerahan agama serta meningkatkan solidaritas masyarakat kampung Cok-Pocok sendiri. Tradisi Sabellesen mempunyai beberapa orientasi urgen atau hikmah. Secara fungsional, Sabellesen diaplikasikan selain untuk bersadaqah, membaca salawat kepada Nabi dan membaca ayat suci al-Qur'an serta momen mempererat tali silaturahmi antar masyarakat, juga ada Kenyakinan bahwa, tradisi Sabellesen dapat menolak balak dan memperlancar rizki. Penelitian ini berdasarkan penelitian lapangan hadir untuk mengkontribusikan serta meningkatkan pendidikan dan keagamaan masyarakat kampung Cok-Pocok Desa Daleman Galis Bangkalan.  &nbsp

Controlled release and angiotensin-converting enzyme inhibition properties of an antihypertensive drug based on a perindopril erbumine-layered double hydroxide nanocomposite

Samer Hasan Hussein Al Ali1, Mothanna Al-Qubaisi2, Mohd Zobir Hussein1,3, Maznah Ismail2,4, Zulkarnain Zainal1, Muhammad Nazrul Hakim51Department of Chemistry, Faculty of Science, 2Laboratory of Molecular Biomedicine, Institute of Bioscience, 3Advanced Materials and Nanotechnology Laboratory, Institute of Advanced Technology, 4Department of Nutrition and Dietetics, Faculty of Medicine and Health Science, 5Department of Biomedical Science, Faculty of Medicine and Health Science, Universiti Putra Malaysia, Serdang, Selangor, MalaysiaBackground: The intercalation of perindopril erbumine into Zn/Al-NO3-layered double hydroxide resulted in the formation of a host-guest type of material. By virtue of the ion-exchange properties of layered double hydroxide, perindopril erbumine was released in a sustained manner. Therefore, this intercalated material can be used as a controlled-release formulation.Results: Perindopril was intercalated into the interlayers and formed a well ordered, layered organic-inorganic nanocomposite. The basal spacing of the products was expanded to 21.7 Å and 19.9 Å by the ion-exchange and coprecipitation methods, respectively, in a bilayer and a monolayer arrangement, respectively. The release of perindopril from the nanocomposite synthesized by the coprecipitation method was slower than that of its counterpart synthesized by the ion-exchange method. The rate of release was governed by pseudo-second order kinetics. An in vitro antihypertensive assay showed that the intercalation process results in effectiveness similar to that of the antihypertensive properties of perindopril.Conclusion: Intercalated perindopril showed better thermal stability than its free counterpart. The resulting material showed sustained-release properties and can therefore be used as a controlled-release formulation.Keywords: perindopril erbumine, layered double hydroxides, ion-exchange, coprecipitation, sustained release, angiotensin-converting enzym