Seismic Hazard Analysis Of Van Province Of Turkey

Within the framework of the performance based earthquake engineering, the seismic hazardanalysis for the Van province in Turkey is performed in probabilistic manner. It is noteworthy that, in probabilistic seismic hazard assessment, as a first stage, data from geological studies and records from the instrumental period were compiled to make a seismic sourcecharacterization for the study region. Then, a seismic hazard model by using EZ-FRISKsoftware is implemented and the probabilistic seismic hazard curves were developed based onthe selected appropriate attenuation relationships, at rock sites, with a probability ofexceedance of 2%, 10% and 50% in 50-year periods. The results of probabilistic seismic hazard analyses revealed peak acceleration values for a typical rock site as 0.47g for 50%probability of exceedance in 50 years, 1.09g for 10% probability of exceedance in 50 yearsand 1.91 g for 2% probability of exceedance in 50 years. The obtained results are comparedwith N-S&E-W component taken from Muradiye station after the earthquake which occurred on 23.10.2011 in Van, N-S & E-W component taken from Van station after thee arthquake which occurred on 9.11.2011 in Van, and the spectral responses proposed forseismic evaluation and retrofit of building structure in Turkey Earthquake Code, Section 7.At the end of this study, it is apprehended that for the performance evaluation of the existing structures Code proposed earthquake response spectra are not sufficient and the currente stimations show that the potential seismic hazard in research area of the Turkey is not well estimatedin the code.

Successful recanalization of previously subintimal stenting of the right coronary artery

Stent placement in the subintimal or false lumen is a rare complication of coronary interventions. Subintimal stenting can cause chronic total occlusion. Angiography images of previously treated CTO cases should be carefully monitored. To avoid placing a stent in the false lumen, it must be absolutely sure that it is inside the lumen. In this case, we presented a successful case of chronic total occlusion in the right coronary artery with a subintimal stent. [Med-Science 2020; 9(3.000): 796-8

Effects of mirtazapine on cisplatin cardiotoxicity in rats

Atypical antidepressant mirtazapine (MIR) is primarily used to treat major depressive disorder. It has not been clarified whether cardiovascular uncertainties and mechanisms of action emerge as problems during the use of mirtazapine. Cisplatin (CIS) is an effective anti-cancer medication used to treat a variety of human malignancies. There were four groups of 32 Wistar albino male rats in all. Rats were split into 4 groups at random. 1. Control Group, 2. CIS Group, 3. MIR Group, 4. MIR+CIS Group. On the 15th day of the study, ECG, heart rate, and blood pressure were determined. Histopathological and biochemical analyses were carried out on cardiac and vascular tissue samples. Comparing the CIS group to the other groups, blood pressure was considerably lower in the CIS group (p [Med-Science 2023; 12(2.000): 579-86

The protective and therapeutic effects of agmatine on isoproterenol-induced myocardial injury in rats

Chronic inflammation and oxidative stress can contribute to the development of cardiovascular diseases. Isoproterenol (ISO), a synthetic catecholamine, is used to study the effects of drugs on cardiotoxicity. Agmatine (AGM) is a type of biogenic amine produced through the decarboxylation of arginine. The purpose of the current study was to evaluate the effects of AGM against ISO-induced cardiotoxicity due to the described roles of AGM in cardiovascular disease. Four groups of thirty-two Wistar Albino rats were divided equally as control, ISO, AGM+ISO, and ISO+AGM. ISO was administered intraperitoneally (i.p.) twice at a dose of 150 mg/kg, at 24-hour intervals. Prior to and after ISO injection, 20 mg/kg of AGM was injected i.p. Hemodynamic measurements and serum and tissue biochemical analyses were evaluated at the end of the experiment. The levels of glutathione (GSH), catalase (CAT), superoxide dismutase (SOD), and malondialdehyde (MDA) in the tissue were measured. In the ISO group, levels of lactate dehydrogenase (LDH) and creatine kinase (CK) were increased significantly (p [Med-Science 2023; 12(4.000): 1290-6