Autoimmune hemolytic anemia predominantly associated with IgA anti-E and anti-c.

A patient with warm autoimmune hemolytic anemia (AIHA) due to predominance of immunoglobulin A (IgA) with an Rh specificity, considered to be the first case in Korea, is described. A 13-year-old male patient with severe hemolytic anemia showed a weak reactivity (1+) in the direct antiglobulin test (DAT) by using anti-IgG antiglobulin reagent. This finding, however, could not fully explain the patient's severe AIHA. When anti-IgA reagent was used for the DAT, strong reactivity (4+) was observed and free anti-E and anti-c autoantibodies were also detected by anti-IgA and anti-IgG reagents. The patient's hemoglobin began to rise with the administration of steroids. Because RBCs coated with multiple types of immunoglobulins are associated with more severe hemolysis than those only with IgG, the DATs using anti-IgA and other reagents are needed for the correct diagnosis when the result of DAT is not compatible with patient's clinical manifestations

Ionized gas outflows in infrared-bright dust-obscured galaxies selected with WISE and SDSS

We present the ionized gas properties of infrared (IR)-bright dust-obscured galaxies (DOGs) that show an extreme optical/IR color, $(i - [22])_{\rm AB} > 7.0$, selected with the Sloan Digital Sky Survey (SDSS) and Wide-field Infrared Survey Explorer (WISE). For 36 IR-bright DOGs that show [OIII]$\lambda$5007 emission in the SDSS spectra, we performed a detailed spectral analysis to investigate their ionized gas properties. In particular, we measured the velocity offset (the velocity with respect to the systemic velocity measured from the stellar absorption lines) and the velocity dispersion of the [OIII] line. We found that the derived velocity offset and dispersion of most IR-bright DOGs are larger than those of Seyfert 2 galaxies (Sy2s) at $z < 0.3$, meaning that the IR-bright DOGs show relatively strong outflows compared to Sy2s. This can be explained by the difference of IR luminosity contributed from active galactic nucleus, $L_{\rm IR}$ (AGN), because we found that (i) $L_{\rm IR}$ (AGN) correlates with the velocity offset and dispersion of [OIII] and (ii) our IR-bright DOGs sample has larger $L_{\rm IR}$ (AGN) than Sy2s. Nevertheless, the fact that about 75% IR-bright DOGs have a large ($>$ 300 km s$^{-1}$) velocity dispersion, which is a larger fraction compared to other AGN populations, suggests that IR-bright DOGs are good laboratories to investigate AGN feedback. The velocity offset and dispersion of [OIII] and [NeIII]$\lambda$3869 are larger than those of [OII]$\lambda$3727, which indicates that the highly ionized gas tends to show more stronger outflows.Comment: 19 pages, 16 figures, and 2 tables, accepted for publication in Ap