763 research outputs found
Sequential Wnt Agonist then Antagonist Treatment Accelerates Tissue Repair and Minimizes Fibrosis
Tissue fibrosis compromises organ function and occurs as a potential
long-term outcome in response to acute tissue injuries. Currently, lack of
mechanistic understanding prevents effective prevention and treatment of the
progression from acute injury to fibrosis. Here, we combined quantitative
experimental studies with a mouse kidney injury model and a computational
approach to determine how the physiological consequences are determined by the
severity of ischemia injury, and to identify how to manipulate Wnt signaling to
accelerate repair of ischemic tissue damage while minimizing fibrosis. The
study reveals that Wnt-mediated memory of prior injury contributes to fibrosis
progression, and ischemic preconditioning reduces the risk of death but
increases the risk of fibrosis. Furthermore, we validated the prediction that
sequential combination therapy of initial treatment with a Wnt agonist followed
by treatment with a Wnt antagonist can reduce both the risk of death and
fibrosis in response to acute injuries
Recommended from our members
Employing a Narrow-Band-Gap Mediator in Ternary Solar Cells for Enhanced Photovoltaic Performance.
Ternary organic solar cells (OSCs) provide a convenient and effective means to further improve the power conversion efficiency (PCE) of binary ones via composition control. However, the role of the third component remains to be explored in specific binary systems. Herein, we report ternary blend solar cells by adding the narrow-band-gap donor PCE10 as the mediator into the PBDB-T:IDTT-T binary blend system. The extended absorption, efficient fluorescence resonance energy transfer, enhanced charge dissociation, and induced tighter molecular packing of the ternary blend films enhance the photovoltaic properties of devices and deliver a champion PCE of 10.73% with an impressively high open-circuit voltage (VOC) of 1.03 V. Good miscibility and similar molecular packing behavior of the components guarantee the desired morphology in the ternary blend films, leading to solar cell devices with over 10% PCEs at a range of compositions. Our results suggest that ternary systems with properly aligned energy levels and overlapping absorption among the components hold great promises to further enhance the performance of corresponding binary ones
Predicting Berth Stay for Tanker Terminals: A Systematic and Dynamic Approach
Given the trend of digitization and increasing number of maritime transport,
prediction of vessel berth stay has been triggered for requirements of
operation research and scheduling optimization problem in the era of maritime
big data, which takes a significant part in port efficiency and maritime
logistics enhancement. This study proposes a systematic and dynamic approach of
predicting berth stay for tanker terminals. The approach covers three
innovative aspects: 1) Data source employed is multi-faceted, including cargo
operation data from tanker terminals, time-series data from automatic
identification system (AIS), etc. 2) The process of berth stay is decomposed
into multiple blocks according to data analysis and information extraction
innovatively, and practical operation scenarios are also developed accordingly.
3) The predictive models of berth stay are developed on the basis of prior data
analysis and information extraction under two methods, including regression and
decomposed distribution. The models are evaluated under four dynamic scenarios
with certain designated cargoes among two different terminals. The evaluation
results show that the proposed approach can predict berth stay with the
accuracy up to 98.81% validated by historical baselines, and also demonstrate
the proposed approach has dynamic capability of predicting berth stay among the
scenarios. The model may be potentially applied for short-term pilot-booking or
scheduling optimizations within a reasonable time frame for advancement of port
intelligence and logistics efficiency
Brief Discussion of Surveying Technology of Three-dimensional Digital Topographic Map
3D digital Topographic drawing adopts 3D profile technology and demonstrates geographic space phenomenon to users, reflects the space features of geographic entity in an integrated and accurate manner and thus realizes even more complete, accurate and straight-forward expression of the objective world. It can not only express the plane relationship between space objects, but also accurately describe and express the ground elevation and geometric object height which upgrade the space expression ability and measuring level of digital map and enhance the space acknowledge ability and analytic ability of map. This article aims to elaborate on 3D digital topographic drawing in three aspects: surveying, mapping and application; mainly introduce the mapping methods of 3D topography and geometric object, integrated matching technologies of topographic model and geometric object model and application of 3D digital topographic drawing. It is expected to have a positive promotion role in the development of 3D GIS
- …