319 research outputs found
Unveiling the nucleon tensor charge at Jefferson Lab: A study of the SoLID case
Future experiments at the Jefferson Lab 12 GeV upgrade, in particular, the
Solenoidal Large Intensity Device (SoLID), aim at a very precise data set in
the region where the partonic structure of the nucleon is dominated by the
valence quarks. One of the main goals is to constrain the quark transversity
distributions. We apply recent theoretical advances of the global QCD
extraction of the transversity distributions to study the impact of future
experimental data from the SoLID experiments. Especially, we develop a simple
strategy based on the Hessian matrix analysis that allows one to estimate the
uncertainties of the transversity quark distributions and their tensor charges
extracted from SoLID data simulation. We find that the SoLID measurements with
the proton and the effective neutron targets can improve the precision of the
u- and d-quark transversity distributions up to one order of magnitude in the
range 0.05 < x < 0.6.Comment: 11 pages, 3 figures, published on Physics Letters
[1,2-Bis(diphenylÂphosphino)ethane-κ2 P,P′](2-carboxylÂatothioÂphenolato-κ2 O,S)nickel(II) methanol solvate
In the title complex, [Ni(C7H4O2S)(C26H24P2)]·CH3OH, the nickel(II) centre adopts an approximately square-planar geometry, with the Ni atom coordinating to the S and O atoms of the bidentate thioÂsalicylate ligand and the two P atoms of the chelating Ph2PCH2CH2PPh2 ligand. There is hydrogen bonding between the methanol solvent molÂecule and the carbonyl O atom of the thioÂsalicylate ligand
A new score system for predicting response to cardiac resynchronization therapy
Background: The aim of this study was to establish a score system derived from clinical, echocardiographic and electrocardiographic indexes and evaluate its clinical value for cardiac resynchronization therapy (CRT) patient selection.
Methods: Ninety-three patients receiving CRT were enrolled. A patient selection score system was generated by the clinical, echocardiographic and electrocardiographic parameters achieving a significant level by univariate and multivariate Cox regression model. The positive response to CRT was a left ventricular end systolic volume decrease of ≥ 15% and not reaching primary clinical endpoint (death or re-hospitalization for heart failure) at the end of follow-up.
Results: Thirty-nine patients were CRT non-responders (41.94%) and 54 were responders (58.06%). A 4-point score system was generated based on tricuspid annular plane systolic exÂcursion (TAPSE), longitudinal strain (LS), and complete left bundle branch block (CLBBB) combined with a wide QRS duration (QRSd). The sensitivity and specificity for prediction of a positive response to CRT at a score > 2 were 0.823 and 0.850, respectively (AUC: 0.92295% CI 0.691–0.916, p< 0.001).
Conclusions: A patient selection score system based on the integration of TAPSE, LS and CLBBB combined with a wide QRSd can help to predict positive response to CRT effectively and reliably
Epidermal Growth Factor Receptor Plays an Anabolic Role in Bone Metabolism In Vivo
While the epidermal growth factor receptor (EGFR)–mediated signaling pathway has been shown to have vital roles in many developmental and pathologic processes, its functions in the development and homeostasis of the skeletal system has been poorly defined. To address its in vivo role, we constructed transgenic and pharmacologic mouse models and used peripheral quantitative computed tomography (pQCT), micro–computed tomography (µCT) and histomorphometry to analyze their trabecular and cortical bone phenotypes. We initially deleted the EGFR in preosteoblasts/osteoblasts using a Cre/loxP system (Col-Cre Egfrf/f), but no bone phenotype was observed because of incomplete deletion of the Egfr genomic locus. To further reduce the remaining osteoblastic EGFR activity, we introduced an EGFR dominant-negative allele, Wa5, and generated Col-Cre EgfrWa5/f mice. At 3 and 7 months of age, both male and female mice exhibited a remarkable decrease in tibial trabecular bone mass with abnormalities in trabecular number and thickness. Histologic analyses revealed decreases in osteoblast number and mineralization activity and an increase in osteoclast number. Significant increases in trabecular pattern factor and structural model index indicate that trabecular microarchitecture was altered. The femurs of these mice were shorter and smaller with reduced cortical area and periosteal perimeter. Moreover, colony-forming unit–fibroblast (CFU-F) assay indicates that these mice had fewer bone marrow mesenchymal stem cells and committed progenitors. Similarly, administration of an EGFR inhibitor into wild-type mice caused a significant reduction in trabecular bone volume. In contrast, EgfrDsk5/+ mice with a constitutively active EGFR allele displayed increases in trabecular and cortical bone content. Taken together, these data demonstrate that the EGFR signaling pathway is an important bone regulator and that it primarily plays an anabolic role in bone metabolism. © 2011 American Society for Bone and Mineral Research
Research Progress on Spatiotemporal Distribution Characteristics of Carbon Stable Isotopes in Wines from New and Old World Countries
With the continuous development of economic globalization, the production and consumption of wine in New and Old World countries have shown a steady growth trend. Wines of different grades and styles have been developed, which are related to geographical origin. Carbon stable isotopes are important indicators for geographical origin identification and have been of great concern to researchers due to their stability and objectivity. This paper summarizes the spatiotemporal distribution characteristics of carbon stable isotopes in ethanol, glycerol, total carbon and other components in wines from the Old (France, Italy, Spain, Germany, Switzerland, Croatia, and Romania) and New Worlds (Australia, South Africa, Chile, Argentina, Brazil, and China). In general, there are small differences in the carbon stable isotope ratio of various components between New and Old World wines, so it is impossible to achieve reliable results when only carbon stable isotope data is used for geographical origin identification. The combined use of carbon stable isotope data with other isotope data and mineral elements can improve the accuracy of geographical origin identification. Furthermore, the application of carbon stable isotope technology is also summarized over the past 15 years with the aim to provide a reference for the establishment of database
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