Additional file 1: of Sample size determination for mediation analysis of longitudinal data

Estimated numbers of required subjects with ICC = 0.3, 0.5, 0.7 and 0.8. (DOCX 27 kb

Dose selection percentage and average number patients allocated to each dose under proposed design.

<p>Note: In each scenario, the first row of number in parentheses corresponds to the dose selection percentage at every dose combination, the second corresponds to the average number of patients allocated to every dose combination.</p

Dose response rates() and Placebo response rate() scenarios.

<p>Dose response rates() and Placebo response rate() scenarios.</p

Average Total Sample Size and Percentage Reduction.

<p>Note: The first row is average total sample size in our proposed design; numbers in parentheses are percentages reduction of sample size as compared to the XJT and the three-stage designs.</p

Recommendation percentage for each dose under Scenarios A–H.

<p>Recommendation percentage for each dose under Scenarios A–H.</p

True probabilities of each grade (0/1,2,3,4) at each dose level (1–6) for eight simulation scenarios (A–H).

<p>True probabilities of each grade (0/1,2,3,4) at each dose level (1–6) for eight simulation scenarios (A–H).</p