In vivo brain images acquired using the MP-RAGE sequence with different delay times (TD): 0 (a), 50 (b), 100 (c), 200 and 400 (d) ms.

<p>In vivo brain images acquired using the MP-RAGE sequence with different delay times (TD): 0 (a), 50 (b), 100 (c), 200 and 400 (d) ms.</p

In vivo brain images acquired using the MP-RAGE sequence with different flip angles: 9° (a), 11° (b), 12° (c), and 14° (d) with τ//TR = 10.1/950/1950 ms.

<p>In vivo brain images acquired using the MP-RAGE sequence with different flip angles: 9° (a), 11° (b), 12° (c), and 14° (d) with τ//TR = 10.1/950/1950 ms.</p

Simulated contrast between the GM and WM as functions of TI for total number of readout RF pulses of 176, 156, and 132.

<p>The interval time between readout RF pulses was set to 10.1; the flip angle was set to 12°.</p

Imaging parameters and CNR efficiencies for our optimized parameters, FreeSurfer, Siemens default, and ADNI.

<p>Imaging parameters and CNR efficiencies for our optimized parameters, FreeSurfer, Siemens default, and ADNI.</p

Simulated signal intensities of the GM, WM and CSF at different delay times (TD) at with N = 132 (slice partial Fourier factors of 6/8).

<p>Simulated signal intensities of the GM, WM and CSF at different delay times (TD) at with N = 132 (slice partial Fourier factors of 6/8).</p

The noise distribution of in-RAGE sequence with different imaging parameters: our optimized parameters (a), FreeSurfer (b), Siemens default (c), and ADNI (d).

<p>The noise distribution of in-RAGE sequence with different imaging parameters: our optimized parameters (a), FreeSurfer (b), Siemens default (c), and ADNI (d).</p

Simulated signal intensity of the CSF and GM-WM contrast for different temporal positions of the read-out RF pulse at different Tis.

<p>Simulated signal intensity of the CSF and GM-WM contrast for different temporal positions of the read-out RF pulse at different Tis.</p

Human brain images acquired with an interval time between readout RF pulses of 10.1°, effective inversion recovery time of 950 ms, total readout RF pulse of 176, and slice partial Fourier factors of 1 (a), and 6/8 (b).

<p>Human brain images acquired with an interval time between readout RF pulses of 10.1°, effective inversion recovery time of 950 ms, total readout RF pulse of 176, and slice partial Fourier factors of 1 (a), and 6/8 (b).</p

In vivo brain images acquired using the MP-RAGE sequence with different imaging parameters: our optimized parameters (a), FreeSurfer (b), Siemens default (c), and ADNI (d).

<p>In vivo brain images acquired using the MP-RAGE sequence with different imaging parameters: our optimized parameters (a), FreeSurfer (b), Siemens default (c), and ADNI (d).</p

In vivo brain images acquired using the MP-RAGE sequence with different effective inversion recovery times : 900 (a), 950 (b), 1020 (c) and 1100 (d) ms at a flip angle of 12°, an interval time between readout RF pulses of 10.1 ms, and slice partial Fourier of 6/8.

<p>In vivo brain images acquired using the MP-RAGE sequence with different effective inversion recovery times : 900 (a), 950 (b), 1020 (c) and 1100 (d) ms at a flip angle of 12°, an interval time between readout RF pulses of 10.1 ms, and slice partial Fourier of 6/8.</p