LAMP: A Database Linking Antimicrobial Peptides

<div><p>The frequent emergence of drug-resistant bacteria has created an urgent demand for new antimicrobial agents. Traditional methods of novel antibiotic development are almost obsolete. Antimicrobial peptides (AMPs) are now regarded as a potential solution to revive the traditional methods of antibiotic development, although, until now, many AMPs have failed in clinical trials. A comprehensive database of AMPs with information about their antimicrobial activity and cytotoxicity will help promote the process of finding novel AMPs with improved antimicrobial activity and reduced cytotoxicity and eventually accelerate the speed of translating the discovery of new AMPs into clinical or preclinical trials. LAMP, a database linking AMPs, serves as a tool to aid the discovery and design of AMPs as new antimicrobial agents. The current version of LAMP has 5,547 entries, comprising 3,904 natural AMPs and 1,643 synthetic peptides. The database can be queried using either simply keywords or combinatorial conditions searches. Equipped with the detailed antimicrobial activity and cytotoxicity data, the cross-linking and top similar AMPs functions implemented in LAMP will help enhance our current understanding of AMPs and this may speed up the development of new AMPs for medical applications. LAMP is freely available at: <a href="http://biotechlab.fudan.edu.cn/database/lamp" target="_blank">http://biotechlab.fudan.edu.cn/database/lamp</a>.</p></div

Screen shots of the LAMP search interface.

<p>The screen shots show the advanced search and result views. Please note that not all fields are shown.</p

Schema of the LAMP database.

<p>Schema of the LAMP database.</p

Methods for GME construction.

<p>Methods for GME construction.</p

Screen shots of a GME result page.

<p>The screen shots show the advanced search and result views. Please note that not all fields are shown.</p

Distribution of calculated isoelectric points for the AMPs in LAMP.

<p>Every bar indicates the number of AMPs calculated to have their isoelectric point range from pI-1 to pI.</p

Top 10 sources of the natural AMPs in LAMP.

<p>Top 10 sources of the natural AMPs in LAMP.</p

Schema of the GMEnzy database.

<p>Schema of the GMEnzy database.</p

Top 10 domains in LAMP.

<p>Top 10 domains in LAMP.</p

Hosts for producing GMEs.

<p>Hosts for producing GMEs.</p