1,594 research outputs found
Messung der Brennstab-Huellrohrtemperatur mit LOFT-typischen Thermoelementen unter Blowdown-Bedingungen in COSIMA. Measurements of clad temperatures with LOFT-typical thermocouples in the COSIMA facility under blowdown conditions
Out-of-pile-Experimente zur Untersuchung schwerer Kernschaeden. SFD-Versuchsanlage CORA - Anlagenbeschreibung
Evidence-based planning and costing palliative care services for children : novel multi-method epidemiological and economic exemplar
Background:
Children’s palliative care is a relatively new clinical specialty. Its nature is multi-dimensional and its delivery necessarily multi-professional. Numerous diverse public and not-for-profit organisations typically provide services and support. Because services are not centrally coordinated, they are provided in a manner that is inconsistent and incoherent. Since the first children’s hospice opened in 1982, the epidemiology of life-limiting conditions has changed with more children living longer, and many requiring transfer to adult services. Very little is known about the number of children living within any given geographical locality, costs of care, or experiences of children with ongoing palliative care needs and their families. We integrated evidence, and undertook and used novel methodological epidemiological work to develop the first evidence-based and costed commissioning exemplar.
Methods:
Multi-method epidemiological and economic exemplar from a health and not-for-profit organisation perspective, to estimate numbers of children under 19 years with life-limiting conditions, cost current services, determine child/parent care preferences, and cost choice of end-of-life care at home.
Results:
The exemplar locality (North Wales) had important gaps in service provision and the clinical network. The estimated annual total cost of current children’s palliative care was about £5.5 million; average annual care cost per child was £22,771 using 2007 prevalence estimates and £2,437- £11,045 using new 2012/13 population-based prevalence estimates. Using population-based prevalence, we estimate 2271 children with a life-limiting condition in the general exemplar population and around 501 children per year with ongoing palliative care needs in contact with hospital services. Around 24 children with a wide range of life-limiting conditions require end-of-life care per year. Choice of end-of-life care at home was requested, which is not currently universally available. We estimated a minimum (based on 1 week of end-of-life care) additional cost of £336,000 per year to provide end-of-life support at home. Were end-of-life care to span 4 weeks, the total annual additional costs increases to £536,500 (2010/11 prices).
Conclusions:
Findings make a significant contribution to population-based needs assessment and commissioning methodology in children’s palliative care. Further work is needed to determine with greater precision which children in the total population require access to services and when. Half of children who died 2002-7 did not have conditions that met the globally used children's palliative care condition categories, which need revision in light of findings
Einrichtung zum Auswechseln von UO₂-PuO₂-Experimentier-Brennstaeben mit Huellschaeden am FR 2
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Current status of antisense RNA-mediated gene regulation in Listeria monocytogenes
Listeria monocytogenes is a Gram-positive human-pathogen bacterium that served as an experimental model for investigating fundamental processes of adaptive immunity and virulence. Recent novel technologies allowed the identification of several hundred non-coding RNAs (ncRNAs) in the Listeria genome and provided insight into an unexpected complex transcriptional machinery. In this review, we discuss ncRNAs that are encoded on the opposite strand of the target gene and are therefore termed antisense RNAs (asRNAs). We highlight mechanistic and functional concepts of asRNAs in L. monocytogenes and put these in context of asRNAs in other bacteria. Understanding asRNAs will further broaden our knowledge of RNA-mediated gene regulation and may provide targets for diagnostic and antimicrobial development
Summary report of neptun investigations into the transient thermal hydraulics of the passive decay heat removal
Die Teststrecke der Blowdown-Versuchsanlage COSIMA. Ausfuehrung, Instrumentierung und Anrisslastwechselzahl der Hochdruckheisswasserstrecke bei den vorliegenden extremen Temperaturaenderungsgeschwindigkeiten
Out-of-pile bundle experiments on severe fuel damage (CORA-program). Objectives, test matrix and facility description
True mass flow meter. Entwicklung und Einsatz eines Massenstrom-Messgeraetes fuer instationaere Zweiphasenstroemungen
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