Stability diagram.

<p>The stability diagram of the 2-frequency chimera state in the <i>θ</i> − <i>ϵ</i> plane. The 2-frequency chimera state, the 2-cluster chimera state, and the synchronous state are distinguished by the red squares, the cyan triangles, and blue circles, respectively. Other parameters are same as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0187067#pone.0187067.g001" target="_blank">Fig 1</a>.</p

Two-frequency chimera state.

<p>(a) Snapshot of the variable <i>X</i>_<i>k</i>. (b) Snapshot of the phase Θ_<i>k</i>. (c) Snapshot of oscillators in the (<i>X</i>, <i>Y</i>) plane (in black). Red curve denotes the orbit of isolated Brusselator. (d) The profile of the mean phase velocity <i>ω</i>_<i>k</i>. (e) The profile of the difference between adjacent oscillators Δ_<i>k</i>. (f) The profile of the variance <i>σ</i>_<i>k</i>. (g) The spatiotemporal plot of the variable <i>X</i>_<i>k</i> after transient time. <i>A</i> = 1, <i>B</i> = 2.1, <i>r</i> = 0.35, <i>θ</i> = −0.1, and <i>ϵ</i> = 0.02.</p

sj-docx-3-ear-10.1177_01455613241233748 – Supplemental material for Application of Biologic Graft in Nasal Septal Perforation Repair

Supplemental material, sj-docx-3-ear-10.1177_01455613241233748 for Application of Biologic Graft in Nasal Septal Perforation Repair by Jianjun Jing, Liang Li, Yongxiang Wu, Liang Zheng, Longfang Zhang, Haihong Li and Hui Wang in Ear, Nose & Throat Journal</p

sj-jpg-2-ear-10.1177_01455613241233748 – Supplemental material for Application of Biologic Graft in Nasal Septal Perforation Repair

Supplemental material, sj-jpg-2-ear-10.1177_01455613241233748 for Application of Biologic Graft in Nasal Septal Perforation Repair by Jianjun Jing, Liang Li, Yongxiang Wu, Liang Zheng, Longfang Zhang, Haihong Li and Hui Wang in Ear, Nose & Throat Journal</p

sj-jpg-1-ear-10.1177_01455613241233748 – Supplemental material for Application of Biologic Graft in Nasal Septal Perforation Repair

Supplemental material, sj-jpg-1-ear-10.1177_01455613241233748 for Application of Biologic Graft in Nasal Septal Perforation Repair by Jianjun Jing, Liang Li, Yongxiang Wu, Liang Zheng, Longfang Zhang, Haihong Li and Hui Wang in Ear, Nose & Throat Journal</p

Novel Nitric Oxide Donors of Phenylsulfonylfuroxan and 3‑Benzyl Coumarin Derivatives as Potent Antitumor Agents

In this work, five new hybrids of phenylsulfonylfuroxan merging 3-benzyl coumarin and their seco-B-ring derivatives <b>2</b>–<b>6</b> were designed and synthesized. Among them, compound <b>3</b> showed the most potent antiproliferation activities with IC₅₀ values range from 0.5 to 143 nM against nine drug-sensitive and four drug-resistant cancer cell lines. Preliminary pharmacologic studies showed that these compounds displayed lower toxicities than that of lead compound <b>1</b>. Compound <b>3</b> obviously induced the early apoptosis and hardly affected the cell cycle of A2780, which was significantly different from compound <b>1</b>. Especially, it gave 559- and 294-fold selectivity antiproliferation activity in P-gp overexpressed drug-resistant cancer cell lines MCF-7/ADR and KB-V compared to their drug-sensitive ones MCF-7 and KB, implying that compounds <b>2</b>–<b>6</b> might have an extra mechanism of anti-MDR-cancer with P-gp overexpression

Correlation between the changes in mIns and NAA (A), mIns and Glu (B), mIns and latency time (C), mIns and apoptotic neurons (D) in senescent mice at different time point.

<p>Correlation between the changes in mIns and NAA (A), mIns and Glu (B), mIns and latency time (C), mIns and apoptotic neurons (D) in senescent mice at different time point.</p

Absolute concentrations of metabolites in the hippocampus by <i>in vitro</i>¹H MRS(±s, μmol/g, n = 6).

<p>NAA: N-acetylaspartate; Glu: glutamate; mIns: myo-inositol; tCr: total creatine (creatine and phosphocreatine); Lac: lactate; Cho:choline; *P<0.01, versus control mice.</p

Comparison of the escape latencies among different groups in MWM test (±s, n = 6).

<p>**p<0.01: senescent mice versus control mice, ^# p<0.05: senescent mice on day 70 versus senescent mice on day 30, at the same time point.</p

Averaged relative percentage changes of metabolites over six subjects between control mice and senescent mice (Change±s.d).

<p>*P<0.01, versus control group. NAA: N-acetylaspartate; Glu: glutamate; mIns: myo-inositol.</p