Defining the Clinical Syndrome of Lumbar Spinal Stenosis: A Recursive Specialist Survey Process

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/147151/1/pmr2491.pd

The Ligamentum Flavum at L4‐5: Relationship With Anthropomorphic Factors and Clinical Findings in Older Persons With and Without Spinal Disorders

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/147136/1/pmr223.pd

A Prospective, Masked 18‐Month Minimum Follow‐up On Neurophysiologic Changes In Persons with Spinal Stenosis, Low Back Pain, and No Symptoms

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/147029/1/pmr2127.pd

Biological aspects of slow sand filtration: past, present and future

For over 200 years, slow sand filtration (SSF) has been an effective means of treating water for the control of microbiological contaminants in both small and large community water supplies. However, such systems lost popularity to rapid sand filters mainly due to smaller land requirements and less sensitivity to water quality variations. SSF is still a particularly attractive process because its operation does not require chemicals or electricity. It can achieve a high level of treatment, which is mainly attributed to naturally-occurring, biochemical processes in the filter. Several microbiologically-mediated purification mechanisms (e.g. predation, scavenging,adsorption and bio-oxidation) have been hypothesised or assumed to occur in the biofilm that forms in the filter but these have not yet been comprehensively verified. Thus, SSFs are operated as 'black boxes' and knowledge gaps pertaining to the underlying ecology and ecophysiology limit the design and optimisation of the technology. The objective of this review is to outline the biological aspects of SSF in to the context of recent developments in molecular microbial ecology

Comparative susceptibility of Atlantic salmon and rainbow trout to Yersinia ruckeri: relationship to O antigen serotype and resistance to serum killing

A study was undertaken to compare the virulence and serum killing resistance properties of Atlantic salmon and rainbow trout Yersinia ruckeri isolates. Five isolates, covering heat-stable O-antigen O1, O2 and O5 serotypes, were tested for virulence towards fry and juveniles of both species by experimental bath challenge. The sensitivity of 15 diverse isolates to non-immune salmon and rainbow trout serum was also examined. All five isolates caused significant mortality in salmon fry. Serotype O1 isolate 06059 caused the highest mortality in salmon (74% and 70% in fry and juveniles, respectively). Isolate 06041, a typical ERM-causing serotype O1 UK rainbow trout strain, caused mortalities in both rainbow trout and salmon. None of the salmon isolates caused any mortalities in 150–250 g rainbow trout, and only serotype O2 isolate 06060 caused any significant mortality (10%) in rainbow trout fry. Disease progression and severity was affected by water temperature. Mortality in salmon caused by the isolates 06059 and 05094 was much higher at 16 °C (74% and 33%, respectively) than at 12 °C (30 and 4% respectively). Virulent rainbow trout isolates were generally resistant to sera from both species, whereas salmon isolates varied in their serum sensitivity. Convalescent serum from salmon and rainbow trout that had been infected by serotype O1 isolates mediated effective classical pathway complement killing of serotype O1 and O5 isolates that were resistant to normal sera. Overall, strains recovered from infected salmon possess a wider range of phenotypic properties (relative virulence, O serotype and possession of serum-resistance factors), compared to ERM-causing rainbow trout isolates