Dexmedetomidine post-treatment attenuates cardiac ischaemia/reperfusion injury by inhibiting apoptosis through HIF-1α signalling.

Hypoxia-inducible factor 1α (HIF-1α) plays a critical role in the apoptotic process during cardiac ischaemia/reperfusion (I/R) injury. This study aimed to investigate whether post-treatment with dexmedetomidine (DEX) could protect against I/R-induced cardiac apoptosis in vivo and in vitro via regulating HIF-1α signalling pathway. Rat myocardial I/R was induced by occluding the left anterior descending artery for 30 minutes followed by 6-hours reperfusion, and cardiomyocyte hypoxia/reoxygenation (H/R) was induced by oxygen-glucose deprivation for 6 hours followed by 3-hours reoxygenation. Dexmedetomidine administration at the beginning of reperfusion or reoxygenation attenuated I/R-induced myocardial injury or H/R-induced cell death, alleviated mitochondrial dysfunction, reduced the number of apoptotic cardiomyocytes, inhibited the activation of HIF-1α and modulated the expressions of apoptosis-related proteins including BCL-2, BAX, BNIP3, cleaved caspase-3 and cleaved PARP. Conversely, the HIF-1α prolyl hydroxylase-2 inhibitor IOX2 partly blocked DEX-mediated cardioprotection both in vivo and in vitro. Mechanistically, DEX down-regulated HIF-1α expression at the post-transcriptional level and inhibited the transcriptional activation of the target gene BNIP3. Post-treatment with DEX protects against cardiac I/R injury in vivo and H/R injury in vitro. These effects are, at least in part, mediated via the inhibition of cell apoptosis by targeting HIF-1α signalling

The Application of Functional Grease in the Army Diet

The comprehensive construction of modern logistics is a major strategic task of military logistics in the new century and a major guarantee to promote the modernization of national defense and military construction.Focusing on the problem of oil intake in the current military dietary structure, this paper take the Soldier special provision nutritional oil（SSPNO）canteens as the research target to explore the properties of various functional grease and the feasibility of applying them to army diets, so as to provide ideas for the design and development of such products, and also provide guarantees for further strengthening the physical quality and combat effectiveness of soldiers

Clincal Observation of Grouping Responsibility Model of Immersion foot nursing In Maternity Ward

目的：责任制护理是一种以病人为中心，在护理过程中运用医学、护理、心理、生理、社会等学科的知识，观察分析病人的全面健康情况，进行有计划和系统的护理，从而提高护理质量和护理人员的素质。引入浸足1号进行整体护理，观察其临床效果。方法：在产科实施分组责任制护理，可以使护士为病人提供连续、全程、无缝隙的护理服务。引入浸足1号护理分为试验组和对照组，使试验组患者增加了家的感觉，并促进了产妇体质的尽快恢复。结果：在实施过程中，我们改变了原来的排班模式，使病人在住院期间有固定的责任护士，增强了护士的责任心，调动了护士的积极性，加强了护患沟通，减少了护理差错和纠纷，提高了护理质量，同时把护士的被动服务变为了主动服务，大大提高了护理质量，促进了产妇康复进程，试验组与对照组比较，护理质量明显提高，统计学比较有显著差异，P<0.05。结论：引入浸足1号护理提高了病人、医生的满意度，提高了护士的自身价值。Objective: Nursing responsibility system is patient centered system, using medicine, nursing, psychology, social and other disciplines of knowledge in the process of nursing, observing and comprehensively analyzing the health condition of patient, proceeding with a systematic nursing plan, so as to improve the quality of nursing and nursing staff quality. Introduction of immersion foot 1 of holistic nursing care, to observe its clinical effect. Methods:The implementation of the system of grouping responsibility nursing in obstetrics, can enable nurses to provide continuous, full, and non-breaking nursing service for patients . Introduction of immersion foot 1 nurses were divided into experimental group and control group, the experimental group increases the feeling of home, which promote maternal physical recovery. Results:In the process of implementation, we changed the original scheduling model, so as to make the patient had the fixed nurses during hospitalization, to strengthen the responsibility of nurses, to arouse the enthusiasm of nurses, to strengthen communication between nurses and patients, to reduce nursing errors and disputes, to improve the quality of care. Meanwhile the nurses change passive service in order to active service, which greatly improved the quality of nursing and promoted maternal rehabilitation process. Compare the experimental group with control group, and significantly improved the quality of nursing, there was statistical significant difference between the groups P<0.05. Conclusion: Introduction of immersion foot 1 care improves patient, physician satisfaction, and the nurses' value

Cuprous oxide nanoparticles selectively induce apoptosis of tumor cells

In the rapid development of nanoscience and nanotechnology, many researchers have discovered that metal oxide nanoparticles have very useful pharmacological effects. Cuprous oxide nanoparticles (CONPs) can selectively induce apoptosis and suppress the proliferation of tumor cells, showing great potential as a clinical cancer therapy. Treatment with CONPs caused a G1/G0 cell cycle arrest in tumor cells. Furthermore, CONPs enclosed in vesicles entered, or were taken up by mitochondria, which damaged their membranes, thereby inducing apoptosis. CONPs can also produce reactive oxygen species (ROS) and initiate lipid peroxidation of the liposomal membrane, thereby regulating many signaling pathways and influencing the vital movements of cells. Our results demonstrate that CONPs have selective cytotoxicity towards tumor cells, and indicate that CONPs might be a potential nanomedicine for cancer therapy

The LAMOST Complete Spectroscopic Survey of Pointing Area (LaCoSSPAr) in the Southern Galactic Cap I. The Spectroscopic Redshift Catalog

We present a spectroscopic redshift catalog from the LAMOST Complete Spectroscopic Survey of Pointing Area (LaCoSSPAr) in the Southern Galactic Cap (SGC), which is designed to observe all sources (Galactic and extra-galactic) by using repeating observations with a limiting magnitude of $r=18.1~mag$ in two $20~deg^2$ fields. The project is mainly focusing on the completeness of LAMOST ExtraGAlactic Surveys (LEGAS) in the SGC, the deficiencies of source selection methods and the basic performance parameters of LAMOST telescope. In both fields, more than 95% of galaxies have been observed. A post-processing has been applied to LAMOST 1D spectrum to remove the majority of remaining sky background residuals. More than 10,000 spectra have been visually inspected to measure the redshift by using combinations of different emission/absorption features with uncertainty of $\sigma_{z}/(1+z)<0.001$. In total, there are 1528 redshifts (623 absorption and 905 emission line galaxies) in Field A and 1570 redshifts (569 absorption and 1001 emission line galaxies) in Field B have been measured. The results show that it is possible to derive redshift from low SNR galaxies with our post-processing and visual inspection. Our analysis also indicates that up to 1/4 of the input targets for a typical extra-galactic spectroscopic survey might be unreliable. The multi-wavelength data analysis shows that the majority of mid-infrared-detected absorption (91.3%) and emission line galaxies (93.3%) can be well separated by an empirical criterion of $W2-W3=2.4$. Meanwhile, a fainter sequence paralleled to the main population of galaxies has been witnessed both in $M_r$/$W2-W3$ and $M_*$/$W2-W3$ diagrams, which could be the population of luminous dwarf galaxies but contaminated by the edge-on/highly inclined galaxies ($\sim30\%$).Comment: 19 pages, 14 figures, 2 MRT, accepted by ApJ

Comparison of Electroacupuncture and Moxibustion for Relieving Visceral Hypersensitivity in Rats with Constipation-Predominant Irritable Bowel Syndrome

Aim. To compare whether there is different effect between electroacupuncture (EA) and moxibustion (Mox) on visceral hypersensitivity (their analgesic effects) in constipation-predominant irritable bowel syndrome (C-IBS). Methods. EA at 1 mA and 3 mA and Mox at 43°C and 46°C were applied to the Shangjuxu (ST37, bilateral) acupoint in rats with C-IBS and normal rats. An abdominal withdrawal reflex (AWR) score was used to assess visceral hypersensitivity. Toluidine blue staining was used to assess mast cell (MC) activity in colon of rats. Immunochemistry was used to measure 5-HT and 5-HT4 receptor expression in the colon. Results. AWR scores in all EA (1 mA and 3 mA) and Mox (43°C and 46°C) treatment groups after colorectal distention (CRD) stimulation pressure of 20, 40, 60, and 80 mmHg were significantly lower than those of the model (MC) group (P all < 0.01). The MC counts and degranulation rates in the colon of all EA and Mox treatment groups and the MC group were significantly higher than those of the NC group (P all < 0.01). MC degranulation rates in the colon of all EA and Mox treatment groups were lower than those of the MC group (P all < 0.05). 5-HT expression in colon of all EA and Mox treatment groups was significantly lower than that of the MC group (P all < 0.01), and 5-HT4R expression in colon of both EA groups was significantly higher than that of the MC group (P both < 0.01). Conclusion. EA and Mox treatments may both ameliorate visceral hypersensitivity at different degree in rats with C-IBS, and EA treatment was better than Mox