1 research outputs found
Boosting Antibacterial Photodynamic Therapy in a Nanosized Zr MOF by the Combination of Ag NP Encapsulation and Porphyrin Doping
Antibacterial
photodynamic therapy (aPDT) is regarded as one of
the most promising antibacterial therapies due to its nonresistance,
noninvasion, and rapid sterilization. However, the development of
antibacterial materials with high aPDT efficacy is still a long-standing
challenge. Herein, we develop an effective antibacterial photodynamic
composite UiO-66-(SH)2@TCPP@AgNPs by Ag encapsulation and
4,4′,4″,4‴-(porphine-5,10,15,20-tetrayl)tetrakis(benzoic
acid) (TCPP) dopant. Through a mix-and-match strategy in the self-assembly
process, 2,5-dimercaptoterephthalic acid containing –SH groups
and TCPP were uniformly decorated into the UiO-66-type framework to
form UiO-66-(SH)2@TCPP. After Ag(I) impregnation and in
situ UV light reduction, Ag NPs were formed and encapsulated into
UiO-66-(SH)2@TCPP to get UiO-66-(SH)2@TCPP@AgNPs.
In the resulting composite, both Ag NPs and TCPP can effectively enhance
the visible light absorption, largely boosting the generation efficiency
of reactive oxygen species. Notably, the nanoscale size enables it
to effectively contact and be endocytosed into bacteria. Consequently,
UiO-66-(SH)2@TCPP@AgNPs show a very high aPDT efficacy
against Gram-negative and Gram-positive bacteria as well as drug-resistant
bacteria (MRSA). Furthermore, the Ag NPs were firmly anchored at the
framework by the high density of –SH moieties, avoiding the
cytotoxicity caused by the leakage of Ag NPs. By in vitro experiments,
UiO-66-(SH)2@TCPP@AgNPs show a very high antibacterial
activity and good biocompatibility as well as the potentiality to
promote cell proliferation