33 research outputs found
Fast label-free multilayered histology-like imaging of human breast cancer by photoacoustic microscopy
The goal of breast-conserving surgery is to completely remove all of the cancer. Currently, no intraoperative tools can microscopically analyze the entire lumpectomy specimen, which results in 20 to 60% of patients undergoing second surgeries to achieve clear margins. To address this critical need, we have laid the foundation for the development of a device that could allow accurate intraoperative margin assessment. We demonstrate that by taking advantage of the intrinsic optical contrast of breast tissue, photoacoustic microscopy (PAM) can achieve multilayered histology-like imaging of the tissue surface. The high correlation of the PAM images to the conventional histologic images allows rapid computations of diagnostic features such as nuclear size and packing density, potentially identifying small clusters of cancer cells. Because PAM does not require tissue processing or staining, it can be performed promptly and intraoperatively, enabling immediate directed re-excision and reducing the number of second surgeries
Light-Front Approach for Pentaquark Strong Decays
Assuming the two diquark structure for the pentaquark state as advocated in
the Jaffe-Wilczek model, we study the strong decays of light and heavy
parity-even pentaquark states using the light-front quark model in conjunction
with the spectator approximation. The narrowness of the Theta width is ascribed
to the p-wave configuration of the diquark pair. Taking the Theta width as a
benchmark, we estimate the rates of the strong decays Xi_{3/2}-- to Xi- pi-,
Sigma- K-, Sigma_{5c}0 to D_s- p, D_{s0}*- p and Xi_{5c}0 to D_s- Sigma+,
D_{s0}^{*-} Sigma+ with Sigma_{5c} Xi_{5c} being antisextet charmed pentaquarks
and D_{s0}* a scalar strange charmed meson. The ratio of Gamma(P_c to Baryon
D_{s0}*)/Gamma(P_c to Baryon D_s) is very useful for verifying the parity of
the antisextet charmed pentaquark P_c. It is expected to be of order unity for
an even parity P_c and much less than one for an odd parity pentaquark.Comment: 24 pages, 2 figure
Decays in QCD Factorization
The hadronic decays are interesting because
experimentally they are the only color-suppressed modes which have been
measured, and theoretically they are calculable by QCD factorization even the
emitted meson is heavy. We analyze the decay within the
framework of QCD factorization in the heavy quark limit. We show explicitly the
scale and -scheme independence of decay amplitudes and infrared
safety of nonfactorizable corrections at twist-2 order. Leading-twist
contributions from the light-cone distribution amplitudes (LCDAs) of the mesons
are too small to accommodate the data; the nonfactorizable corrections to naive
factorization are small and not significant. We study the twist-3 effects due
to the kaon and find that the coefficient is largely enhanced by
the nonfactorizable spectator interactions arising from the twist-3 kaon LCDA
, which are formally power-suppressed but chirally,
logarithmically and kinematically enhanced. Therefore, factorization breaks
down at twist-3 order. Higher-twist effects of are briefly discussed.
Our result also resolves the long-standing sign ambiguity of ,
which turns out to be positive for its real part.Comment: 18 pages, 2 figures. Typos in Eqs.(3.4), (3.5), and (3.6) are
correcte
Implications of Recent Measurements of Hadronic Charmless B Decays
Implications of recent CLEO measurements of hadronic charmless B decays are
discussed. (i) Employing the Bauer-Stech-Wirbel (BSW) model for form factors as
a benchmark, the data indicate that the form factor
is smaller than that predicted by the BSW model, whereas the
data of imply that the form factors are greater than the BSW model's values. (ii) The tree-dominated
modes imply that the effective
number of colors N_c(LL) for (V-A)(V-A) operators is preferred to be smaller,
while the current limit on shows that N_c(LR)>3. The data of and clearly indicate that . (iii) In
order to understand the observed suppression of and
non-suppression of modes, both being governed by the form factor
, the unitarity angle is preferred to be greater than
. By contrast, the new measurement of no
longer strongly favors . (iv) The observed pattern K^-\pi^+\sim
\ov K^0\pi^-\sim {2\over 3}K^-\pi^0 is consistent with the theoretical
expectation: The constructive interference between electroweak and QCD penguin
diagrams in the mode explains why {\cal B}(B^-\to K^-\pi^0)>{1\over
2}{\cal B}(\ov B^0\to K^-\pi^+). (v) The observation \nc(LL)<3<\nc(LR) and
our preference for \nc(LL)\sim 2 and \nc(LR)\sim 6 are justified by a
recent perturbative QCD calculation of hadronic rare B decays in the heavy
quark limit.Comment: 21 pages; CLEO measurements of several charmless B decay modes are
updated. Discussion of the unitarity angle gamma in the \rho\pi mode is
revise
Updated Analysis of a_1 and a_2 in Hadronic Two-body Decays of B Mesons
Using the recent experimental data of , , and various model calculations on form
factors, we re-analyze the effective coefficients a_1 and a_2 and their ratio.
QCD and electroweak penguin corrections to a_1 from and
a_2 from are estimated. In addition to the
model-dependent determination, the effective coefficient a_1 is also extracted
in a model-independent way as the decay modes are related by
factorization to the measured semileptonic distribution of at . Moreover, this enables us to extract model-independent
heavy-to-heavy form factors, for example,
and
. The determination of the magnitude of
a_2 from depends on the form factors ,
and at . By requiring that a_2 be
process insensitive (i.e., the value of a_2 extracted from and
states should be similar), as implied by the factorization
hypothesis, we find that form factors are severely constrained;
they respect the relation . Form factors and at
inferred from the measurements of the longitudinal
polarization fraction and the P-wave component in are
obtained. A stringent upper limit on a_2 is derived from the current bound on
\ov B^0\to D^0\pi^0 and it is sensitive to final-state interactions.Comment: 33 pages, 2 figures. Typos in Tables I and IX are corrected. To
appear in Phys. Rev.
Design and synthesis of oligoamide-based double a-helix mimetics (Eur. J. Org. Chem. 17/2013)
The cover picture shows the binding of transcription factors to nucleic acids. Top left: multicomponent protein; bottom right: leucine zipper; centre: bis-oligobenzamide peptidomimetic; background: DNA chains. The xanthene-linked bis-oligobenzamide shown in the centre is an example of a super-secondary structural protein mimic. This work details the synthesis of oligobenzamide and oligopyridylamide strands connected through various spacers, allowing tuning of the inter-helix angle and thus the potential nucleic acid or protein binding properties. Details are discussed in the article by A. D. Hamilton et al. on page 3427 ff
Design and synthesis of oligoamide-based double a-helix mimetics
An extensive series of bis-oligobenzamides and bis-oligopyridylamides have been efficiently prepared and studied by X-ray analysis and computational methods. A modular synthesis led to double ?-helix mimics bearing between two and ten branched side-chains. The inter-helix angle and distance can be tuned by varying the length and rigidity of the spacer, thereby reproducing the recognition domains of a range of super-secondary structures