Physical Model Test for Soft Soil With or Without Prefabricated Vertical Drain with Loading

The paper builds a physical model of testing in the laboratory with the parametric tempered glass box 0.5  0.5 1.2 m (length  width  depth) containing saturated clay to study the settlement and consolidation when loading increased gradually over time. The research covers herein to present the monitoring of settlement and pore water pressure, settlement calculation, numerical simulation using PLAXIS software V8.2 based on the results of soil physical and mechanical tests before and after loading in case of having or not prefabricated vertical drain (PVD). In case of no PVD, the calculation and numerical simulation using the soil parameters before loading have the differential settlement from the monitoring data, approximately 3.86 mm (10.45%), 0.41 mm (1.11%) respectively. Meanwhile, the deviation in the case using data after loading is about 2.29 mm (6.20%), 0.21 mm (0.56%) respectively. In case of PVD, the calculation and numerical simulation with the testing result of before loading deviation from the settlement monitoring by subsidence meter is 2.91 mm (7.88%), 44.42 mm (120.28%), calculation and simulation with the testing result of after loading deviation is 0.80 mm (2.17%), 1.26 mm (3.41%). In the case of having PVD, the difference in calculation, subsidence observation, and numerical simulation between the mechanical properties before and after loading is significant, when using the mechanical data after loading then the results are quite close to the subsidence of observation and simulation rather than before loading.

Iridoid glycosides from Morinda tomentosa and their endoplasmic reticulum stress modulation activity

Three iridoids 1 - 3, asperulosidic acid, daphylloside, and asperuloside, were isolated from the methanol extract of the leaves of Morinda tomentosa. Their chemical structures were elucidated by 1D- and 2D-NMR spectra and in comparison with those reported in the literature. The effects of these compounds on the endoplasmic reticulum stress in XBP1-eGFP-transfected the 293 T cells were measured. Compound 3 significantly reduced the ER-stress both in DMSO-treated and thapsigargin-treated cells. Unlike this compound, compound 3 selectively reduced thapsigargin-induced ER-stress without any effect on the level of XBP1 splicing in DMSO-treated cells. These results suggested that compounds 2 and 3 can be suggested as new ER stress regulators

Awareness and preparedness of healthcare workers against the first wave of the COVID-19 pandemic: A cross-sectional survey across 57 countries.

BACKGROUND: Since the COVID-19 pandemic began, there have been concerns related to the preparedness of healthcare workers (HCWs). This study aimed to describe the level of awareness and preparedness of hospital HCWs at the time of the first wave. METHODS: This multinational, multicenter, cross-sectional survey was conducted among hospital HCWs from February to May 2020. We used a hierarchical logistic regression multivariate analysis to adjust the influence of variables based on awareness and preparedness. We then used association rule mining to identify relationships between HCW confidence in handling suspected COVID-19 patients and prior COVID-19 case-management training. RESULTS: We surveyed 24,653 HCWs from 371 hospitals across 57 countries and received 17,302 responses from 70.2% HCWs overall. The median COVID-19 preparedness score was 11.0 (interquartile range [IQR] = 6.0-14.0) and the median awareness score was 29.6 (IQR = 26.6-32.6). HCWs at COVID-19 designated facilities with previous outbreak experience, or HCWs who were trained for dealing with the SARS-CoV-2 outbreak, had significantly higher levels of preparedness and awareness (p<0.001). Association rule mining suggests that nurses and doctors who had a 'great-extent-of-confidence' in handling suspected COVID-19 patients had participated in COVID-19 training courses. Male participants (mean difference = 0.34; 95% CI = 0.22, 0.46; p<0.001) and nurses (mean difference = 0.67; 95% CI = 0.53, 0.81; p<0.001) had higher preparedness scores compared to women participants and doctors. INTERPRETATION: There was an unsurprising high level of awareness and preparedness among HCWs who participated in COVID-19 training courses. However, disparity existed along the lines of gender and type of HCW. It is unknown whether the difference in COVID-19 preparedness that we detected early in the pandemic may have translated into disproportionate SARS-CoV-2 burden of disease by gender or HCW type

Practices in security and confidentiality of HIV/AIDS patients’ information: A national survey among staff at HIV outpatient clinics in Vietnam

<div><p>Introduction</p><p>Breach of confidentiality or invasion of privacy from the collection and use of medical records, particularly those of patients with HIV/AIDS or other diseases sensitive to stigmatization, should be prevented by all related stakeholders in healthcare settings. The main focus of this study was to assess practices regarding security and confidentiality of HIV-related information among staff at HIV outpatient clinics (HIV-OPCs) in Vietnam.</p><p>Methods</p><p>A descriptive cross-sectional study was conducted at all 312 HIV-OPCs across the country using an online survey technique.</p><p>Results</p><p>In general, the staff practices for securing and protecting patient information were at acceptable levels. Most staff had proper measures and practices for maintaining data security; however, the protection of patient confidentiality, particularly for data access, sharing, and transfer still required improvement. Most HIV-OPC staff had good or moderate knowledge and positive perceptions towards security and confidentiality issues. Staff who were not trained in the practice of security measures differed significantly from those who were trained (OR: 3.74; 95%CI: 1.44–9.67); staff needing improved knowledge levels differed significantly from those with good (OR: 5.20; 95%CI: 2.39–11.32) and moderate knowledge levels (OR: 5.10; 95%CI: 2.36–11.00); and staff needing improved perception levels differed significantly from those with good (i.e., with 100% proper practices) and moderate perception levels (OR: 5.67; 95%CI: 2.93–10.95). Staff who were not trained in the protection of data confidentiality differed significantly from those who were trained (OR: 2.18; 95%CI: 1.29–3.65).</p><p>Conclusions</p><p>Training is an important factor to help raise the levels of proper practices regarding confidentiality and security, to improve knowledge and raise awareness about change among staff. The operation and management of HIV treatment and care in Vietnam are currently transitioning from separate healthcare clinics (HIV-OPC) into units integrated into general hospitals/healthcare facilities. The findings of this study highlight topics that could be used for improving management and operation of information system and revising guidelines and regulations on protection measures/strategies for data security and confidentiality of HIV/AIDS patients by Vietnam health authorities or other countries facing similar situations. Secure infrastructure and secure measures for data access and use are very important, worthwhile investments. The provision of continuous training and active enforcement and monitoring of the practices of healthcare personnel might lead to an improved understanding and acknowledegement of the importance of national policies/guidelines regarding HIV-related patient information.</p></div

Characteristics of survey respondents (N = 400).

<p>Characteristics of survey respondents (N = 400).</p

Associations of practices on security measures, according to different staff characteristics.

<p>Associations of practices on security measures, according to different staff characteristics.</p

Associations of practices on protection of confidentiality, according to different staff characteristics.

<p>Associations of practices on protection of confidentiality, according to different staff characteristics.</p

Proportions of security and confidentiality practices.

<p>Proportions of security and confidentiality practices.</p