Angular distributions of γ rays from the 7Li(p,γ) reaction at low energies

Angular distributions of the 14–17 MeV γ rays from the 7Li(p,γ) reaction at Ep=450, 402, and 80 keV were measured at 0°≤θlab≤135°, using a BGO detector and a 28-μg/cm2 LiF target. The angular distributions at Ep=450 and 402 keV agree with the previous results by Mainsbridge; at Ep=80 keV the ground-state transition is anisotropic on the order of 20%, confirming recent results by Chasteler et al

Study of Single W production in e-gamma collisions through the decay lepton spectrum to probe gamma-WW couplings

We investigate the effect of anomalous gamma-W-W couplings in e-gamma --> nu W through the angular and energy spectrum of the secondary leptons. Within the narrow-width approximation, a semi-analytical study of the secondary lepton energy-angle double distribution is considered. Utility of observables derived from this is demonstrated by considering the anomalous coupling, delta-kappa-gamma. Results of our investigation for typical ILC machine considered at Ecm = 300-1000 GeV re-affirms potential of this collider as a precision machine.Comment: Typos corrected, discussion added in section 2 for clarity, error in fig.2 corrected, figures 7 and 8 replaced with better resolutio

Assessing Regulatory Impact Analyses: The Failure of Agencies to Comply With Executive Order 12,866

None.Environment, Health and Safety, Regulatory Reform

Assessing the Quality of Regulatory Impact Analyses

This study provides the most comprehensive evaluation of the quality of recent economic analyses that agencies conduct before finalizing major regulations. We construct a new dataset that includes analyses of forty-eight major health, safety, and environmental regulations from mid-1996 to mid-1999. This dataset provides detailed information on a variety of issues, including an agency's treatment of benefits, costs, net benefits, discounting, and uncertainty. We use this dataset to assess the quality of recent economic analyses and to determine the extent to which they are consistent with President Clinton's Executive Order 12866 and the benefit-cost guidelines issued by the Office of Management and Budget (OMB). We find that economic analyses prepared by regulatory agencies typically do not provide enough information to make decisions that will maximize the efficiency or effectiveness of a rule. Agencies quantified net benefits for only 29 percent of the rules. Agencies failed to discuss alternatives in 27 percent of the rules and quantified costs and benefits of alternatives in only 31 percent of the rules. Our findings strongly suggest that agencies generally failed to comply with the executive order and adhere to the OMB guidelines. We offer specific suggestions for improving the quality of analysis and the transparency of the regulatory process, including writing clear executive summaries, making analyses available on the Internet, providing more careful consideration of alternatives to a regulation, and estimating net benefits of a regulation when data on costs and benefits are provided.

S-Benzylthiuronium Salts of Some Barhituric Acid Derivatives*

Preparation and properties of the S-benzylthiuronium salts of fourteen barbituric acid derivatives are described

S-Benzylthiuronium Salts of Some Barhituric Acid Derivatives*

Preparation and properties of the S-benzylthiuronium salts of fourteen barbituric acid derivatives are described

Bone mineral content after renal transplantation

Forearm bone mineral content (BMC), as evaluated by photonabsorption densitometry, was measured in 28 cadaver kidney donor recipients who entered the study 8 weeks postoperatively and were followed up for 18 months. BMC decreased signifiantly (p<0.05) but marginally in placebo-treated patients (n=14) (initial BMC 1.09±0.25 g/cm; final BMC 1.05±0.24). Fourteen patients were prophylactically given 1,25(OH)2vitamin D3 in a dose which avoided hypercalcemia and hypercalciuria (sim0.25 µg/day); under 1,25(OH)2 vitamin D3 prophylaxis a significant decrease of forearm BMC was observed no longer (initial BMC 0.94±0.21 g/cm; final BMC 0.95±0.21), but the difference between placebo and 1,25(OH)2 vitamin D3 narrowly missed statistical significance (p=0.066). It is concluded that the decrease of forearm BMC is negligible in transplant recipients with low steroid regimens. The data suggest a trend for prophylaxis with 1,25(OH)2 vitamin D3 to slightly ameliorate forearm (cortical) BMC loss

A prospective study of resuscitative outcomes at a downtown Greenville SC hospital using Connect Care versus CodeNet for cardiac arrest documentation

Our study was looks at the difference between 2 systems used to document cardiac arrests in a hospital setting. One is a new machine that is called CodeNet. This documentation device was compared to the documentation system at Saint Francis Hospital in downtown Greenville, SC. When the details of a cardiac arrest are recorded (e.g., time it began, how many shocks were given, and what interval the shocks were given), this information can be used to look for patterns that predict survival. This can hopefully be used to create new protocols that will increase the patient\u27s chance of survival. This is being accomplished through chart review (cardiac arrest sheet) of cardiopulmonary arrest for 12 months and data collected with the CodeNet from cardiac arrests that occur in theIntensive Care UnitandCritical Care Unit. More data is being collected, but the preliminary results seem to indicate that CodeNet isa much moreefficient way to document the details of a cardiac arrest

Copine A, a calcium-dependent membrane-binding protein, transiently localizes to the plasma membrane and intracellular vacuoles in Dictyostelium

BACKGROUND: Copines are soluble, calcium-dependent membrane binding proteins found in a variety of organisms. Copines are characterized as having two C2 domains at the N-terminal region followed by an "A domain" at the C-terminal region. The "A domain" is similar in sequence to the von Willebrand A (VWA) domain found in integrins. The presence of C2 domains suggests that copines may be involved in cell signaling and/or membrane trafficking pathways. RESULTS: We have identified six copines genes in the Dictyostelium discoideum genome, cpnA-cpnF, and have focused our studies on cpnA. CpnA is expressed throughout development and was shown to be capable of binding to membranes in a calcium-dependent manner in vitro. A GFP-tagged CpnA was also capable of binding to membranes in a calcium-dependent manner in vitro. In live wildtype Dictyostelium cells expressing GFP-CpnA, GFP-CpnA was typically found in the cytoplasm without any specific localization to membranes. However, in a small subset of starved cells, GFP-CpnA was observed to bind transiently (typically ~1–10 s) to the plasma membrane and intracellular vacuoles. In some cells, the transient membrane localization of GFP-CpnA was observed to occur multiple times in an oscillatory manner over several minutes. In plasma membrane disrupted cells, GFP-CpnA was observed to associate with the plasma membrane and intracellular vacuoles in a calcium-dependent manner. In fixed cells, GFP-CpnA labeled the plasma membrane and intracellular vacuoles, including contractile vacuoles, organelles of the endolysosomal pathway, and phagosomes. CONCLUSION: Our results show that Dictyostelium has multiple copine homologs and provides an excellent system in which to study copine function. The localization of a GFP-tagged CpnA to the plasma membrane, contractile vacuoles, organelles of the endolysosomal pathway, and phagosomes suggests that CpnA may have a role in the function of these organelles or the trafficking to and from them. In addition, we hypothesize that the observed transient oscillatory membrane localization of GFP-CpnA in a small subset of starved cells is caused by fast calcium waves and speculate that CpnA may have a role in development, particularly in the differentiation of stalk cells