104 research outputs found

    Using Open Journal Systems to Move from Paper Production to Online Open Access

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    The Canadian Journal of Sociology is an independent, peer-reviewed publication, originally constituted as a charitable organization in 1975. From 1975 to 2008, CJS was printed quarterly and mailed to its subscribers. The move to Open Access and the Open Journal System has meant some adjustments philosophically and pragmatically. In outlining them below, we hope to guide other journals who may be contemplating the same move. While we focus on our use of the Open Journal System, the comments are easily transferrable to other programs and situations

    Effectiveness of Prevention Interventions with Youth at High Risk of Drug Abuse

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    A recent report describes three types of prevention programs: universal, selected, and indicated (Institute of Medicine 1994). Universal prevention approaches are those that serve the entire population who share a general risk to the disorder without regard to specific risk status. Selected prevention approaches serve those whose precursors of problem behaviors are elevated but who have not yet manifested the problem behavior to be prevented. Indicated prevention approaches serve those who have initiated the problem behavior to be prevented but have not yet developed a serious or chronic behavior problem and do not warrant at that time a clinical diagnosis of the disorder according to the Diagnostic and Statistical Manual of Mental Disorders (DSM-III-R or DSM-IV). The effects of universally applied prevention approaches for substance abuse and other problems are well documented in the literature (Hansen et al. 1990; Hawkins et al. 1992; Moskowitz 1989). Less attention has been given to the effects of prevention approaches with selected youth whose specific characteristics put them at higher risk. This chapter first examines several definitions of high-risk youth and chooses one based on youths’ exposure to consistently identified, longitudinal correlates or risk factors for substance abuse. This discussion is followed by a selective review of prevention program research studies chosen for their demonstrated effectiveness of program promise for reducing risk among high-risk populations

    Assessment of cochlear synaptopathy by electrocochleography to low frequencies in a preclinical model and human subjects

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    Cochlear synaptopathy is the loss of synapses between the inner hair cells and the auditory nerve despite survival of sensory hair cells. The findings of extensive cochlear synaptopathy in animals after moderate noise exposures challenged the long-held view that hair cells are the cochlear elements most sensitive to insults that lead to hearing loss. However, cochlear synaptopathy has been difficult to identify in humans. We applied novel algorithms to determine hair cell and neural contributions to electrocochleographic (ECochG) recordings from the round window of animal and human subjects. Gerbils with normal hearing provided training and test sets for a deep learning algorithm to detect the presence of neural responses to low frequency sounds, and an analytic model was used to quantify the proportion of neural and hair cell contributions to the ECochG response. The capacity to detect cochlear synaptopathy was validated in normal hearing and noise-exposed animals by using neurotoxins to reduce or eliminate the neural contributions. When the analytical methods were applied to human surgical subjects with access to the round window, the neural contribution resembled the partial cochlear synaptopathy present after neurotoxin application in animals. This result demonstrates the presence of viable hair cells not connected to auditory nerve fibers in human subjects with substantial hearing loss and indicates that efforts to regenerate nerve fibers may find a ready cochlear substrate for innervation and resumption of function

    LSST Science Book, Version 2.0

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    A survey that can cover the sky in optical bands over wide fields to faint magnitudes with a fast cadence will enable many of the exciting science opportunities of the next decade. The Large Synoptic Survey Telescope (LSST) will have an effective aperture of 6.7 meters and an imaging camera with field of view of 9.6 deg^2, and will be devoted to a ten-year imaging survey over 20,000 deg^2 south of +15 deg. Each pointing will be imaged 2000 times with fifteen second exposures in six broad bands from 0.35 to 1.1 microns, to a total point-source depth of r~27.5. The LSST Science Book describes the basic parameters of the LSST hardware, software, and observing plans. The book discusses educational and outreach opportunities, then goes on to describe a broad range of science that LSST will revolutionize: mapping the inner and outer Solar System, stellar populations in the Milky Way and nearby galaxies, the structure of the Milky Way disk and halo and other objects in the Local Volume, transient and variable objects both at low and high redshift, and the properties of normal and active galaxies at low and high redshift. It then turns to far-field cosmological topics, exploring properties of supernovae to z~1, strong and weak lensing, the large-scale distribution of galaxies and baryon oscillations, and how these different probes may be combined to constrain cosmological models and the physics of dark energy.Comment: 596 pages. Also available at full resolution at http://www.lsst.org/lsst/sciboo

    Table of Contents 33(1)

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    Bring it on home: Home drug testing and the relocation of the war on drugs

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    While the war on drugs is often claimed to have failed in multifarious ways, anti-drug strategies in the United States continue. The discourses through which anti-drug sentiments and policies are forwarded are, however, being reinvented in light of this failure, favoring an inclusionary and less state-centered disease trope for certain populations of drug users. In this article we argue that the privileging of the disease trope within anti-drug rhetoric facilitates the introduction of home drug testing as a means of 'state-free' drug regulation offered to specific populations. The advent of home drug testing is congruent with neoliberal trends towards mobilizing private entities like the family to engage in regulatory practices that were previously concerns of the state. A market for home drug testing has evolved out of rhetoric around private security, and the commodification of notions of safety. Home drug testing is theorized as a tool of surveillance that offers a very particular scientific gaze trained on the seemingly indefensible adolescent body. Teens, however, are not defenseless in this scheme. We document the concomitant rise of resistance technologies and tactics designed to assist teens and others to 'beat' the tests
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