Earth rotation and core topography

The NASA Geodynamics program has as one of its missions highly accurate monitoring of polar motion, including changes in length of day (LOD). These observations place fundamental constraints on processes occurring in the atmosphere, in the mantle, and in the core of the planet. Short-timescale (t less than or approx 1 yr) variations in LOD are mainly the result of interaction between the atmosphere and the solid earth, while variations in LOD on decade timescales result from the exchange of angular momentum between the mantle and the fluid core. One mechanism for this exchange of angular momentum is through topographic coupling between pressure variations associated with flow in the core interacting with topography at the core-mantel boundary (CMB). Work done under another NASA grant addressing the origin of long-wavelength geoid anomalies as well as evidence from seismology, resulted in several models of CMB topography. The purpose of work supported by NAG5-819 was to study further the problem of CMB topography, using geodesy, fluid mechanics, geomagnetics, and seismology. This is a final report

GPS survey of the western Tien Shan

There were two major developments in 1994 in our collaborative GPS experiment in the Tien Shan of the Former Soviet Union (FSU). Both were motivated by our expectation that we will ultimately obtain better science at lower cost if we involve our colleagues in the FSU more deeply in (1) the collection and (2) the analysis of data. As an experimental test of the concept of having our local collaborators carry out the field work semi-autonomously, we sent 6 MIT receivers to the Tien Shan for a period of 3 months. To enable our collaborators to have the capability for data analysis, we provided computers for two data analysis centers and organized a two-week training session. This report emphasizes the rationale for deeper involvement of FSU scientists, describes the training sessions, discusses the data collection, and presents the results. We also discuss future plans. More detailed discussion of background, general scientific objectives, discussions with collaborators, and results for the campaigns in 1992 and 1993 have been given in previous reports

Application of Global Positioning Measurements to Continental Collision in the Pamir-Tien Shan Region, Central Asia and GPS Survey of the Western Tien Shan

In this report, we summarize what we have accomplished with five years of funding from NASA under its DOSE program, and with a comparable level of funding from NSF. We describe the development of a GPS network in the Tien Shan of Kyrgyzstan and Kazakhstan of the former Soviet Union, the analysis of data, and the main results. This discussion presents the state of the current network, which has grown significantly since the termination of our DOSE grants, with continued support both from NSF through its continental dynamics program and from NASA's SENH program. Although grants from NASA's DOSE program did not support this growth not directly, it did so indirectly by building the infrastructure that has enabled further expansion in an area where otherwise there would be only a small GPS presence. We note how the network has grown over time, but the emphasis of this discussion is on the quantity and quality of measurements that we have made

A tomographic image of mantle structure beneath Southern California

We determined the variations in seismic structure beneath southern California by using a tomographic method of inversion on teleseismic P delays recorded with the Southern California Array. The algorithm employed was a modified form of an Algebraic Reconstruction Technique (ART) used in medical X‐ray imaging. Deconvolution with an empirically estimated point spread function was also used to help in focusing the image. The inversion reveals two prominent features beneath the region. The first is a thin, vertical wedge directly beneath the Transverse Ranges that is 2‐3% faster than the surrounding region. This feature deepens to the east, attaining a maximum depth of about 250 km beneath the San Bernardino Mountains. The second feature is a major zone of low velocity material that is 2‐4% slow under the Salton Trough rift valley, extending to a depth of about 125 km. Two possible explanations for the spatial association of the Transverse Ranges with the velocity anomaly below are lithospheric subduction or small‐scale sublithospheric convection in the region of the Big Bend of the San Andreas Fault. The low velocity anomaly beneath the Salton Trough is consistent with convective upwelling there

Estimates of Seismic Potential in the Marmara Sea Region from Block Models of Secular Deformation Constrained by Global Positioning System Measurements

We model the geodetically observed secular velocity field in northwestern Turkey with a block model that accounts for recoverable elastic-strain accumulation. The block model allows us to estimate internally consistent fault slip rates and locking depths. The northern strand of the North Anatolian fault zone (NAFZ) carries approximately four times as much right-lateral motion (∼24 mm/yr) as does the southern strand. In the Marmara Sea region, the data show strain accumulation to be highly localized. We find that a straight fault geometry with a shallow locking depth of 6-7 km fits the observed Global Positioning System velocities better than does a stepped fault geometry that follows the northern and eastern edges of the sea. This shallow locking depth suggests that the moment release associated with an earthquake on these faults should be smaller, by a factor of 2.3, than previously inferred assuming a locking depth of 15 km.Earth and Planetary Science

Transport of unstable respiratory failure patients on extracorporeal life support

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/31292/1/0000198.pd

Transcription, one allele at a time

A recent study presents a technique allowing one to image transcription from a single gene copy in live cells, and highlights the dynamic nature of transcriptional regulation

DIAPH3 Governs the Cellular Transition to the Amoeboid Tumour Phenotype

Therapies for most malignancies are generally ineffective once metastasis occurs. While tumour cells migrate through tissues using diverse strategies, the signalling networks controlling such behaviours in human tumours are poorly understood. Here we define a role for the Diaphanous-related formin-3 (DIAPH3) as a non-canonical regulator of metastasis that restrains conversion to amoeboid cell behaviour in multiple cancer types. The DIAPH3 locus is close to RB1, within a narrow consensus region of deletion on chromosome 13q in prostate, breast and hepatocellular carcinomas. DIAPH3 silencing in human carcinoma cells destabilized microtubules and induced defective endocytic trafficking, endosomal accumulation of EGFR, and hyperactivation of EGFR/MEK/ERK signalling. Silencing also evoked amoeboid properties, increased invasion and promoted metastasis in mice. In human tumours, DIAPH3 down-regulation was associated with aggressive or metastatic disease. DIAPH3-silenced cells were sensitive to MEK inhibition, but showed reduced sensitivity to EGFR inhibition. These findings have implications for understanding mechanisms of metastasis, and suggest that identifying patients with chromosomal deletions at DIAPH3 may have prognostic value