238 research outputs found
Long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency
A new case of 3-hydroxyacyl-CoA dehydrogenase deficiency is described with a relatively benign course
Early postoperative complications in patients with Crohn's disease given and not given preoperative total parenteral nutrition
The Human Serum Metabolome
Continuing improvements in analytical technology along with an increased interest in performing comprehensive, quantitative metabolic profiling, is leading to increased interest pressures within the metabolomics community to develop centralized metabolite reference resources for certain clinically important biofluids, such as cerebrospinal fluid, urine and blood. As part of an ongoing effort to systematically characterize the human metabolome through the Human Metabolome Project, we have undertaken the task of characterizing the human serum metabolome. In doing so, we have combined targeted and non-targeted NMR, GC-MS and LC-MS methods with computer-aided literature mining to identify and quantify a comprehensive, if not absolutely complete, set of metabolites commonly detected and quantified (with today's technology) in the human serum metabolome. Our use of multiple metabolomics platforms and technologies allowed us to substantially enhance the level of metabolome coverage while critically assessing the relative strengths and weaknesses of these platforms or technologies. Tables containing the complete set of 4229 confirmed and highly probable human serum compounds, their concentrations, related literature references and links to their known disease associations are freely available at http://www.serummetabolome.ca
Endothelial dysfunction and diabetes: roles of hyperglycemia, impaired insulin signaling and obesity
The Physiological Regulation of Skeletal Muscle Fatty Acid Supply and Oxidation During Moderate-Intensity Exercise
Intravenous Infusion of α-Oxoisocaproate: Influence on Amino Acid and Nitrogen Metabolism in Patients with Liver Cirrhosis
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