Vitamin D and the risk of treatment-resistant and atypical depression: A Mendelian randomization study

Observational evidence has implicated vitamin D levels as a risk factor in major depressive disorder (MDD). Confounding or reverse causation may be driving these observed associations, with studies using genetics indicating little evidence of an effect. However, genetic studies have relied on broad definitions of depression. The genetic architecture of different depression subtypes may vary since MDD is a highly heterogenous condition, implying potentially diverging requirements in therapeutic approaches. We explored the associations between vitamin D and two subtypes of MDD, for which evidence of a causal link could have the greatest clinical benefits: treatment-resistant depression (TRD) and atypical depression (AD). We used a dual approach, combining observational data with genetic evidence from polygenic risk scores (PRS) and two-sample Mendelian randomization (MR), in the UK Biobank. There was some evidence of a weak association between vitamin D and both incident TRD (Ncases = 830) and AD (Ncases = 2366) in observational analyses, which largely attenuated when adjusting for confounders. Genetic evidence from PRS and two-sample MR, did not support a causal link between vitamin D and either TRD (Ncases = 1891, OR = 1.01 [95%CI 0.78, 1.31]) or AD (Ncases = 2101, OR = 1.04 [95%CI 0.80, 1.36]). Our comprehensive investigations indicated some evidence of an association between vitamin D and TRD/AD observationally, but little evidence of association when using PRS and MR, mirroring findings of genetic studies of vitamin D on broad depression phenotypes. Results do not support further clinical trials of vitamin D in these MDD subtypes but do not rule out that small effects may exist that require larger samples to detect

Monte-Carlo calculation of longitudinal and transverse resistivities in a model Type-II superconductor

We study the effect of a transport current on the vortex-line lattice in isotropic type-II superconductors in the presence of strong thermal fluctuations by means of 'driven-diffusion' Monte Carlo simulations of a discretized London theory with finite magnetic penetration depth. We calculate the current-voltage (I-V) characteristics for various temperatures, for transverse as well as longitudinal currents I. From these characteristics, we estimate the linear resistivities R_xx=R_yy and R_zz and compare these with equilibrium results for the vortex-lattice structure factor and the helicity moduli. From this comparison a consistent picture arises, in which the melting of the flux-line lattice occurs in two stages for the system size considered. In the first stage of the melting, at a temperature T_m, the structure factor drops to zero and R_xx becomes finite. For a higher temperature T_z, the second stage takes place, in which the longitudinal superconducting coherence is lost, and R_zz becomes finite as well. We compare our results with related recent numerical work and experiments on cuprate superconductors.Comment: 4 pages, with eps figure

Numerical studies of the phase diagram of layered type II superconductors in a magnetic field

We report on simulations of layered superconductors using the Lawrence-Doniach model in the framework of the lowest Landau level approximation. We find a first order phase transition with a $B(T)$ dependence which agrees very well with the experimental ``melting'' line in YBaCuO. The transition is not associated with vortex lattice melting, but separates two vortex liquid states characterised by different degrees of short-range crystalline order and different length scales of correlations between vortices in different layers. The transition line ends at a critical end-point at low fields. We find the magnetization discontinuity and the location of the lower critical magnetic field to be in good agreement with experiments in YBaCuO. Length scales of order parameter correlations parallel and perpendicular to the magnetic field increase exponentially as 1/T at low temperatures. The dominant relaxation time scales grow roughly exponentially with these correlation lengths. We find that the first order phase transition persists in the presence of weak random point disorder but can be suppressed entirely by strong disorder. No vortex glass or Bragg glass state is found in the presence of disorder. The consistency of our numerical results with various experimental features in YBaCuO, including the dependence on anisotropy, and the temperature dependence of the structure factor at the Bragg peaks in neutron scattering experiments is demonstrated.Comment: 25 pages (revtex), 19 figures included, submitted to PR

Effects of Electronic Correlations on the Thermoelectric Power of the Cuprates

We show that important anomalous features of the normal-state thermoelectric power S of high-Tc materials can be understood as being caused by doping dependent short-range antiferromagnetic correlations. The theory is based on the fluctuation-exchange approximation applied to Hubbard model in the framework of the Kubo formalism. Firstly, the characteristic maximum of S as function of temperature can be explained by the anomalous momentum dependence of the single-particle scattering rate. Secondly, we discuss the role of the actual Fermi surface shape for the occurrence of a sign change of S as a function of temperature and doping.Comment: 4 pages, with eps figure

Preparative fractionation of a random copolymer (SAN) with respect to either chain length or chemical composition

The possibilities to fractionate copolymers with respect to their chemical composition on a preparative scale by means of the establishment of liquid/liquid phase equilibria were studied for random copolymers of styrene and acrylonitrile (san). Experiments with solutions of san in toluene have shown that fractionation does in this quasi-binary system, where demixing results from marginal solvent quality, take place with respect to the chain length of the polymer only. On the other hand, if phase separation is induced by a second, chemically different polymer one can find conditions under which fractionation with respect to composition becomes dominant. This opportunity is documented for the quasi-ternary system dmac/san/polystyrene, where the solvent dimethyl acetamide is completely miscible with both polymers. The theoretical reasons for the different fractionation mechanisms are discussed

1/\omega-flux-noise and dynamical critical properties of two-dimensional XY-models

We have numerically studied the dynamic correlation functions in thermodynamic equilibrium of two-dimensional O(2)-symmetry models with either bond (RSJ) or site (TDGL) dissipation as a function of temperature T. We find that above the critical temperature the frequency dependent flux noise $S_{\Phi}(\omega)\sim \vert 1+ {(\omega/\Omega)}^2\vert^{-\alpha (T)/2}$, with $0.85\leq \alpha (TDGL)(T)\leq 0.95$ and $1.17 \leq \alpha (RSJ)(T) \leq 1.27$, while the dynamic critical exponents $z(TDGL)\sim 2.0$ and $z(RSJ)\sim 0.9$. Contrary to expectation the TDGL results are in closer agreement with the experiments in Josephson-junction arrays by Shaw et al., than those from the RSJ model. We find that these results are related to anomalous vortex diffusion through vortex clusters.Comment: 4 pages Rev-Tex, two figures in postscript. To appear In Physical Review Letter

Genetic variants linked to education predict longevity

Educational attainment is associated with many health outcomes, including longevity. It is also known to be substantially heritable. Here, we used data from three large genetic epidemiology cohort studies (Generation Scotland, n = ∼17,000; UK Biobank, n = ∼115,000; and the Estonian Biobank, n = ∼6,000) to test whether education-linked genetic variants can predict lifespan length. We did so by using cohort members' polygenic profile score for education to predict their parents' longevity. Across the three cohorts, meta-analysis showed that a 1 SD higher polygenic education score was associated with ∼2.7% lower mortality risk for both mothers (total ndeaths= 79,702) and ∼2.4% lower risk for fathers (total ndeaths= 97,630). On average, the parents of offspring in the upper third of the polygenic score distribution lived 0.55 y longer compared with those of offspring in the lower third. Overall, these results indicate that the genetic contributions to educational attainment are useful in the prediction of human longevity

Transverse depinning and melting of a moving vortex lattice in driven periodic Josephson junction arrays

We study the effect of thermal fluctuations in a vortex lattice driven in the periodic pinning of a Josephson junction array. The phase diagram current ($I$) vs. temperature ($T$) is studied. Above the critical current $I_c(T)$ we find a moving vortex lattice (MVL) with anisotropic Bragg peaks. For large currents $I\gg I_c(T)$, there is a melting transition of the MVL at $T_M(I)$. When applying a small transverse current to the MVL, there is no dissipation at low $T$. We find an onset of transverse vortex motion at a transverse depinning temperature $T_{tr}(I)<T_M(I)$.Comment: 4 pages, 4 figures, Figure 2 changed, added new reference

Melting and transverse depinning of driven vortex lattices in the periodic pinning of Josephson junction arrays

We study the non-equilibrium dynamical regimes of a moving vortex lattice in the periodic pinning of a Josephson junction array (JJA) for {\it finite temperatures} in the case of a fractional or submatching field. We obtain a phase diagram for the current driven JJA as a function of the driving current I and temperature T. We find that when the vortex lattice is driven by a current, the depinning transition at $T_p(I)$ and the melting transition at $T_M(I)$ become separated even for a field for which they coincide in equilibrium. We also distinguish between the depinning of the vortex lattice in the direction of the current drive, and the {\it transverse depinning} in the direction perpendicular to the drive. The transverse depinning corresponds to the onset of transverse resistance in a moving vortex lattice at a given temperature $T_{tr}$. For driving currents above the critical current we find that the moving vortex lattice has first a transverse depinning transition at low T, and later a melting transition at a higher temperature, $T_{M}>T_{tr}$.Comment: 17 pages, 19 figure