Dynamical structure factors of S=1/2S=1/2 two-leg spin ladder systems

We investigate dynamical properties of $S=1/2$ two-leg spin ladder systems. In a strong coupling region, an isolated mode appears in the lowest excited states, while in a weak coupling region, an isolated mode is reduced and the lowest excited states become a lower bound of the excitation continuum. We find in the system with equal intrachain and interchain couplings that due to a cyclic four-spin interaction, the distribution of the weights for the dynamical structure factor and characteristics of the lowest excited states are strongly influenced. The dynamical properties of two systems proposed for ${\rm SrCu_2O_3}$ are also discussed.Comment: 5 pages, 6 figure

Consideration of patient preferences and challenges in storage and access of pharmacogenetic test results

Pharmacogenetic (PGx) testing is one of the primary drivers of personalized medicine. The use of PGx testing may provide a lifetime of benefits through tailoring drug dosing and selection of multiple medications to improve therapeutic outcomes and reduce adverse responses. We aimed to assess public interest and concerns regarding sharing and storage of PGx test results that would facilitate the re-use of PGx data across a lifetime of care

Remark on Pauli-Villars Lagrangian on the Lattice

It is interesting to superimpose the Pauli-Villars regularization on the lattice regularization. We illustrate how this scheme works by evaluating the axial anomaly in a simple lattice fermion model, the Pauli-Villars Lagrangian with a gauge non-invariant Wilson term. The gauge non-invariance of the axial anomaly, caused by the Wilson term, is remedied by a compensation among Pauli-Villars regulators in the continuum limit. A subtlety in Frolov-Slavnov's scheme for an odd number of chiral fermions in an anomaly free complex gauge representation, which requires an infinite number of regulators, is briefly mentioned.Comment: 14 pages, Phyzzx. The final version to appear in Phys. Rev.

Dynamical structure factors of the magnetization-plateau state in the S=1/2S=1/2 bond-alternating spin chain with a next-nearest-neighbor interaction

We calculate the dynamical structure factors of the magnetization-plateau state in the $S=1/2$ bond-alternating spin chain with a next-nearest-neighbor interaction. The results show characteristic behaviors depending on the next-nearest-neighbor interaction $\alpha$ and the bond-alternation $\delta$. We discuss the lower excited states in comparison with the exact excitation spectrums of an effective Hamiltonian. From the finite size effects, characteristics of the lowest excited states are investigated. The dispersionless mode of the lowest excitation appears in adequate sets of $\alpha$ and $\delta$, indicating that the lowest excitation is localized spatially and forms an isolated mode below the excitation continuum. We further calculate the static structure factors. The largest intensity is located at $q=\pi$ for small $\delta$ in fixed $\alpha$. With increasing $\delta$, the wavenumber of the largest intensity shifts towards $q=\pi/2$, taking the incommensurate value.Comment: to appear in Phys. Rev. B (2001

High pressure phase diagrams of CeRhIn5_5 and CeCoIn5_5 studied by ac calorimetry

The pressure-temperature phase diagrams of the heavy fermion antiferromagnet CeRhIn$_5$ and the heavy fermion superconductor CeCoIn$_5$ have been studied under hydrostatic pressure by ac calorimetry and ac susceptibility measurements using diamond anvil cells with argon as pressure medium. In CeRhIn$_5$, the use of a highly hydrostatic pressure transmitting medium allows for a clean simultaneous determination by a bulk probe of the antiferromagnetic and superconducting transitions. We compare our new phase diagram with the previous ones, discuss the nature (first or second order) of the various lines, and the coexistence of antiferromagnetic order and superconductivity. The link between the collaps of the superconducting heat anomaly and the broadening of the antiferromagnetic transition points to an inhomogeneous appearence of superconductivity below $P_c \approx 1.95$ GPa. Homogeneous bulk superconductivity is only observed above this critical pressure. We present a detailed analysis of the influence of pressure inomogeneities on the specific heat anomalies which emphasizes that the observed broadening of the transitions near $P_c$ is connected with the first order transition. For CeCoIn$_5$ we show that the large specific heat anomaly observed at $T_c$ at ambient pressure is suppressed linearly at least up to 3 GPa

Survey of US public attitudes toward pharmacogenetic testing

To assess public attitudes and interest in pharmacogenetic (PGx) testing, we conducted a random-digit-dial telephone survey of U.S. adults, achieving a response rate of 42% (n=1139). Most respondents expressed interest in PGx testing to predict mild or serious side effects (73% ±3.29% and 85% ±2.91%, respectively), guide dosing (91%) and assist with drug selection (92%). Younger individuals (ages 18–34) were more likely to be interested in PGx testing to predict serious side effects (vs. ages 55+), as well as Whites, those with a college degree, and who had experienced side effects from medications. However, most respondents (78% ±3.14%) were not likely to have a PGx test if there was a risk that their DNA sample or test result could be shared without their permission. Given differences in interest among some groups, providers should clearly discuss the purpose of testing, alternative testing options (if available), and policies to protect patient privacy and confidentiality

Coexistence of magnetism and superconductivity in CeRh1-xIrxIn5

We report a thermodynamic and transport study of the phase diagram of CeRh1-xIrxIn5. Superconductivity is observed over a broad range of doping, 0.3 < x < 1, including a substantial range of concentration (0.3 < x <0.6) over which it coexists with magnetic order (which is observed for 0 < x < 0.6). The anomalous transition to zero resistance that is observed in CeIrIn5 is robust against Rh substitution. In fact, the observed bulk Tc in CeRh0.5Ir0.5In5 is more than double that of CeIrIn5, whereas the zero-resistance transition temperature is relatively unchanged for 0.5 < x < 1

Survey of genetic counselors and clinical geneticists' use and attitudes toward pharmacogenetic testing

Pharmacogenetic (PGx) testing aims to improve therapeutic outcomes through tailoring treatment based on a patient’s genetic risk for non-response and/or an adverse event. Given their expertise, geneticists could facilitate the use of PGx testing; however, , the preparedness and perceived role of the clinical genetics community is unclear. To assess the attitudes, preparedness, and perceived roles of geneticists in the delivery of PGx testing, we conducted a survey of 1500 randomly selected board-certified genetic counselors and clinical geneticists in the U.S (response rate: 37.8% (n=516)). Twelve percent of genetic counselors and 41% of clinical geneticists indicated that they had ordered or coordinated patient care for PGx testing, a seemingly high proportion at this early stage of adoption. Almost all respondents had some education on pharmacogenetics, though only 28% of counselors and 58% of clinical geneticists indicated they felt well-informed about PGx testing. About half of counselors (52%) and clinical geneticists (46%) felt they would play ‘some’ role in the delivery of PGx testing; 17% and 19%, respectively, felt that they would play ‘no’ or ‘a little’ role. At this early stage of PGx testing, the role of geneticists and genetic counselors is unclear. However, their experience may aid in readying PGx testing and informing delivery strategies into clinical practice

phot1 inhibition of ABCB19 primes lateral auxin fluxes in the shoot apex required for phototropism

It is well accepted that lateral redistribution of the phytohormone auxin underlies the bending of plant organs towards light. In monocots, photoreception occurs at the shoot tip above the region of differential growth. Despite more than a century of research, it is still unresolved how light regulates auxin distribution and where this occurs in dicots. Here, we establish a system in Arabidopsis thaliana to study hypocotyl phototropism in the absence of developmental events associated with seedling photomorphogenesis. We show that auxin redistribution to the epidermal sites of action occurs at and above the hypocotyl apex, not at the elongation zone. Within this region, we identify the auxin efflux transporter ATP-BINDING CASSETTE B19 (ABCB19) as a substrate target for the photoreceptor kinase PHOTOTROPIN 1 (phot1). Heterologous expression and physiological analyses indicate that phosphorylation of ABCB19 by phot1 inhibits its efflux activity, thereby increasing auxin levels in and above the hypocotyl apex to halt vertical growth and prime lateral fluxes that are subsequently channeled to the elongation zone by PIN-FORMED 3 (PIN3). Together, these results provide new insights into the roles of ABCB19 and PIN3 in establishing phototropic curvatures and demonstrate that the proximity of light perception and differential phototropic growth is conserved in angiosperm