Endogenous opioid peptides and epilepsy

In recent years a large number of pept:ides, many of which were originall.y characterized in non-neural tissues, have been reported to be present in the central nervous system ( CNS) . The detection of these peptides within the CNS has raised many questions regarding their source and mechanism of action. In view of the accumulating information, it seems that the function of the classical neurotransmitters in the CNS would be better clarified by elucidating the role of the brain neuropeptides. The classification of the major categories of the main peptides, as listed below, is a some what arbitrary one as it is based on the first localization of a given peptide, while the opioid peptide family is given separately. For many of the peptides described in brain, their major functional role is still unknown. However, even before the major discoveries in the past decade, the opiates were known to possess selective and unique pharmacological properties. It was well known that opiates were effective in the treatment of pain and were useful as cough suppressants. They are also known to depress respiration and blood pressure and to exert an effect on behaviour, like euphoria, sedation and depression. The diversity/complexity of their properties suggests that like the catecholamines, endogenous opioids may have a basic, multisystem regulation essential to the maintenance of homeostasis and to the survival of the organism. In the last years we have tried to reveal one of these petidergic secrets and focussed our attention on the opioid pe~ides, more specifically in relation to the excitatory phenomena which they might induce after systemic or intraventricular administratio

Ejercicios para volatineros

El hilo común de los dibujos a color consiste en el juego de balancear y danzar con la forma y la figura. El tema de cada uno de ellos puede ser observado como una (pro-)puesta de escena teatral libre a desarrollar. La coreografía de las formas surge a modo de escritura automática guiada por un inconsciente sentido del dinamismo y la armonía que trata de encontrar su equilibrio entre ambos. Sin embargo, existen influencias formales y temáticas de la vanguardia rusa y otras expresiones orientales como el grabado japonés o el espectáculo tradicional coreano de funambulismo 'Jultagi'

Prediction of Mental Health Services Use One Year After Regular Referral to Specialized Care Versus Referral to Stepped Collaborative Care

FSW - Self-regulation models for health behavior and psychopathology - ou

Acute tryptophan depletion in depressed patients treated with a selective serotin-noradrenalin reuptake inhibitor: Augmentation of antidepressant response?

De samenhang tussen somatische en psychische (dys)functie

Collaborative mental health care versus care as usual in a primary care setting: A randomized controlled trial.

De samenhang tussen somatische en psychische (dys)functie

Acute tryptophan depletion as a model of depressive relapse: behavioural specificity and ethical considerations.

FSW - Self-regulation models for health behavior and Psychopathology - Ou

AMORE - Mission concept overview for a progressively independent and self-sustainable lunar habitat

Throughout the last decade a renewed interest for lunar space exploration has been expressed through the announcements of many ambitious missions such as Artemis. Annually the Space Station Design Workshop (SSDW) tasks students and young professionals to design a space station concept in a con-current engineering environment. In line with the elevated interest on the Moon this year's SSDW was centred around a self-sustainable lunar habitat. This paper presents the conceptual design of Team Blue at the SSDW 2021. Advanced Moon Operations and Resource Extraction (AMORE) is conceptu-alized as a public-private cooperation for the creation of a lunar platform that acts as an outpost for human exploration and robotic In-situ Resources Utilization (ISRU). AMORE’s proposed location is near the rim of Shackleton Crater at the Lunar South Pole. This location provides opportunities in science and ISRU and favourable sun coverage and thermal conditions. The terrain offers a natural shield for debris and storage advantages for ISRU. The mission architecture allows for incremental crew size increase through a modular dome structure, an initial prioritization of ISRU and a sustainable resource management strategy. Based on the identified system requirements, the initial configuration envisions one core module and two modular structures that would serve as greenhouses or living spaces. The phasing of the base assembly is designed to allow for adequate conditions of an increasing crew size capacity. The greenhouse modules are designed to provide all required oxygen and most required food supply. The modules are constructed using lightweight inflatable structures, while a regolith shell will provide radiation as well as thermal and micrometeorite protection. For reliable communication, a cus-tom relay network named Lunar Earth Telecommand Telemetry Relay (LETTER) is proposed. The mis-sion architecture analysis includes several methods to financially utilize the mission. These include a range of services on the lunar surface such as training facilities for deep space missions, leasing habitats to other Moon explorers, and performing scientific and technological demonstrations. A variety of rovers will be used throughout the mission that will assist in various aspects. In addition to this, a scalable hybrid power generation system that utilizes the abundant sunlight and nuclear energy assures a suffi-cient power supply throughout the entire mission lifetime. This research presents a holistic architecture for a Moon base, which provides an approach to initially utilize the Moon. Within this context, the mission concept is primarily based on already existing or currently in-development technologies. Hence, AMORE offers an approach for a financially and technologically feasible as well as a continuous and expandable human presence on the lunar surfac