5 research outputs found
Longitudinal Lung Function Decrease in Subjects with Spontaneous Healed Pulmonary Tuberculosis
<div><p>Objective</p><p>We compared the longitudinal course of post-bronchodilator Forced Expiratory Volume in 1 second (pFEV1) over a 10-year period in subjects with spontaneous healed pulmonary tuberculosis (SHPTB) with that in normal subjects.</p><p>Methods</p><p>We prospectively investigated 339 subjects with SHPTB and 3211 normal subjects. pFEV1 values measured biannually over 10 years were analyzed using mixed effects model.</p><p>Results</p><p>At baseline, there were no differences in gender, smoking amount, and mean height, except mean age (50.0 ± 8.1 VS. 48.1 ± 7.3, <i>P</i>< 0.001) between the SHPTB and normal group. 52% of the 339 participants with SHPTB and 56% of the 3211 normal participants participated till the end of study. According to the final model, the SHPTB group showed significantly larger decrease in the average pFEV1 over the time than the normal group (P< 0.001) adjusted for gender, age, height, smoking pack years, and time effects. Especially, the interaction effect between time and group was statistically significant (P = 0.036).</p><p>Conclusion</p><p>The average lung function in terms of pFEV1 decreases faster in subjects with SHPTB than in normal individuals over time.</p></div
Fixed effects from mixed effects models estimating the longitudinal course of post FEV1 during 10 years between SHAPTB group and normal group.
<p>Fixed effects from mixed effects models estimating the longitudinal course of post FEV1 during 10 years between SHAPTB group and normal group.</p
Longitudinal course of post FEV1 from mixed effects model for 10 years in the normal and SHPTB groups.
<p>Nl = normal group; SHPTB = spontaneous healed pulmonary tuberculosis group.</p
Participants flowchart for ten years of follow up.
<p>FEV1 = forced expiratory volume in 1 second; yr = year; FU = follow-up.</p
Characteristics of the participants with SHPTB and comparison normal subjects at baseline.
<p>Characteristics of the participants with SHPTB and comparison normal subjects at baseline.</p