7,432 research outputs found
An experimental study of the effects of autocratic, student-centered and laissez-faire group leadership on college orientation classes
Thesis (Ed.M.)--Boston UniversityThe purpose of this study is to attempt to determine the effect of different types of leadership for freshman orientation groups at Boston University School of Educatio
Entanglement creation and distribution on a graph of exchange-coupled qutrits
We propose a protocol that allows both the creation and distribution of
entanglement, resulting in two distant parties (Alice and Bob) conclusively
sharing a bipartite Bell State. The system considered is a graph of three-level
objects ("qutrits") coupled by SU(3) exchange operators. The protocol begins
with a third party (Charlie) encoding two lattice sites in unentangled states,
and allowing unitary evolution under time. Alice and Bob perform a projective
measurement on their respective qutrits at a given time, and obtain a
maximally-entangled Bell state with a certain probablility. We also consider
two further protocols, one based on simple repetition and the other based on
successive measurements and conditional resetting, and show that the cumulative
probability of creating a Bell state between Alice and Bob tends to unity.Comment: Added seven references, clarified argument for eqn (16
Multi-level, multi-party singlets as ground states and their role in entanglement distribution
We show that a singlet of many multi-level quantum systems arises naturally
as the ground state of a physically-motivated Hamiltonian. The Hamiltonian
simply exchanges the states of nearest-neighbours in some network of qudits
(d-level systems); the results are independent of the strength of the couplings
or the network's topology. We show that local measurements on some of these
qudits project the unmeasured qudits onto a smaller singlet, regardless of the
choice of measurement basis at each measurement. It follows that the
entanglement is highly persistent, and that through local measurements, a large
amount of entanglement may be established between spatially-separated parties
for subsequent use in distributed quantum computation.Comment: Corrected method for physical preparatio
Entanglement in Valence-Bond-Solid States
This article reviews the quantum entanglement in Valence-Bond-Solid (VBS)
states defined on a lattice or a graph. The subject is presented in a
self-contained and pedagogical way. The VBS state was first introduced in the
celebrated paper by I. Affleck, T. Kennedy, E. H. Lieb and H. Tasaki
(abbreviation AKLT is widely used). It became essential in condensed matter
physics and quantum information (measurement-based quantum computation). Many
publications have been devoted to the subject. Recently entanglement was
studied in the VBS state. In this review we start with the definition of a
general AKLT spin chain and the construction of VBS ground state. In order to
study entanglement, a block subsystem is introduced and described by the
density matrix. Density matrices of 1-dimensional models are diagonalized and
the entanglement entropies (the von Neumann entropy and Renyi entropy) are
calculated. In the large block limit, the entropies also approach finite
limits. Study of the spectrum of the density matrix led to the discovery that
the density matrix is proportional to a projector.Comment: Published version, 80 pages, 8 figures; references update
Maximum tumor diameter is associated with event-free survival in PET-negative patients with stage I/IIA Hodgkin lymphoma.
Introduction: the high cure rates achieved in early-stage (ES) Hodgkin lymphoma (HL) are one of the great successes of hemato-oncology, but late treatment-related toxicity undermines long-term survival. Improving overall survival and quality of life further will require maintaining disease control while potentially de-escalating chemotherapy and/or omitting radiotherapy to reduce late toxicity. Accurate stratification of patients is required to facilitate individualized treatment approaches. Response assessment using 18F-fluorodeoxyglucose positron emission tomography (PET) is a powerful predictor of outcome in HL,1,2 and has been used in multiple studies, including the United Kingdom National Cancer Research Institute Randomised Phase III Trial to Determine the Role of FDG–PET Imaging in Clinical Stages IA/IIA Hodgkin’s Disease (UK NCRI RAPID) trial, to investigate whether patients achieving complete metabolic remission (CMR) can be treated with chemotherapy alone.3-5 These PET-adapted trials have demonstrated that omitting radiotherapy results in higher relapse rates, but without compromising overall survival.3-5
For the 75% of patients who achieved CMR in RAPID, neither baseline clinical risk stratification (favorable/unfavorable) nor PET (Deauville score 1/2) predicted disease relapse; additional biomarkers are needed.1 Tumor bulk has long been recognized as prognostic in HL,1,6 but there remains uncertainty about the significance and definition of bulk in the era of PET-adapted treatment.7 We performed a subsidiary analysis of RAPID to assess the prognostic value of baseline maximum tumor dimension (MTD) in patients achieving CMR.
Methods: ee have previously reported the RAPID trial design, primary results, and outcomes according to pretreatment risk stratification and PET score.1,3 Patients were aged 16 to 75 years with untreated ES-HL and without B-symptoms or mediastinal bulk (mass > 1/3 internal mediastinal diameter at T5/6).6 Metabolic response after 3 cycles of ABVD chemotherapy (doxorubicin, bleomycin, vinblastine, and dacarbazine) was centrally assessed using PET (N = 562). Patients with CMR (ie, Deauville score 1-2) were randomly assigned to receive involved field radiotherapy (IFRT; n = 208) or no further therapy (NFT; n = 211). PET-positive patients (score, 3-5; n = 143) received a fourth cycle of ABVD and IFRT.
Baseline disease assessment was performed by computed tomography, and bidimensional target lesion measurements were reported by local radiologists in millimeters. The association of baseline MTD with HL-related event-free survival (EFS: progression or HL-related death) and progression-free survival (PFS) (progression or any-cause death) was assessed using Kaplan-Meier and Cox regression analyses. Non-HL deaths were either related to primary treatment toxicity or occurred in HL remission.1
United Kingdom ethical approval for the RAPID trial was via the UK Multicentre Research ethics committee.
Results and discussion: baseline patient characteristics have been previously described.1 Median age was 34 years (range, 16-75 years); 184 (37.4%) of 492 patients had unfavorable risk by European Organisation for Research and Treatment of Cancer criteria, and 155 (32.3%) of 480 by German Hodgkin Study Groupcriteria. Median MTD for patients achieving CMR was 3.0 cm (interquartile range, 2.0-4.0 cm) and 3.0 cm (interquartile range, 1.8-4.5 cm) in the NFT and IFRT groups, respectively, whereas PET-positive patients had a median MTD of 3.9 cm (interquartile range, 2.8-5.1 cm). After a median follow-up of 61.6 m, 44 HL progression events occurred: 21 NFT, 9 IFRT and 14 PET-positive. No patient received salvage treatment without documented progression. Only 5 HL-related deaths occurred (1 IFRT, 4 PET-positive), and 12 non-HL deaths (4 NFT, 6 IFRT, 2 PET-positive).1
For patients with CMR (N = 419), there was a strong association between MTD and EFS (hazard ratio [HR], 1.19; 95% confidence interval [CI], 1.02-1.39; P = .02), adjusting for treatment group, with an approximate 19% increase in HL risk per centimeter increase in MTD. The association was similar in both treatment groups (NFT HR, 1.20 [95% CI, 0.99-1.44; P = .06]; IFRT HR, 1.19 [95% CI, 0.92-1.55; P = .19]). The observed effect sizes did not markedly change after adjusting for baseline clinical risk factors, and similar results were observed for PFS (supplemental Table 1). In contrast, for PET-positive patients, there was no association between MTD and EFS (HR, 0.88; 95% CI, 0.70-1.11; P = .29) or PFS (HR, 0.87; 95% CI, 0.70-1.08; P = .21).
In an exploratory analysis within the NFT group, MTD was dichotomized using increasing 1-cm intervals to investigate the relationship between MTD thresholds and EFS. The largest effect size was observed with an MTD threshold of ≥5 cm (Table 1). Similar results were observed for PFS; this threshold also performed best in time-dependent receiver operating characteristic curve analyses. It was not possible to assess MTD thresholds in the IFRT group with only 9 events. Among all randomized patients, 79 (18.9%) had MTD of ≥5 cm, the majority with mediastinal (n = 43), supraclavicular (n = 17), or cervical (n = 16) locations. Five-year EFS for patients with MTD of ≥5 cm randomly assigned to NFT and IFRT was 79.3% (n = 39; 95% CI, 66.6%-92.0%) and 94.9% (n = 40; 95% CI, 88.0%-100%), respectively (P = .03; Figure 1)
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Measuring the Efficacy of Leaders to Assess Information and Make Decisions in a Crisis: The C-LEAD Scale.
Based on literature and expert interviews, we developed the Crisis Leader Efficacy in Assessing and Deciding scale (C-LEAD) to capture the efficacy of leaders to assess information and make decisions in a public health and safety crisis. In Studies 1 and 2, we find that C-LEAD predicts decision-making difficulty and confidence in a crisis better than a measure of general leadership efficacy. In Study 3, C-LEAD predicts greater motivation to lead in a crisis, more crisis leader role-taking, and more accurate performance while in a crisis leader role. These findings support the scale’s construct validity and broaden our theoretical understanding of the nature of crisis leader efficacy
A Test of Some Principles In Information Campaign Planning
ALTHOUGH INFORMATION campaigns are standard fare for agricultural colleges and the U. S. Department of Agriculture, the campaign reported here may be of special interest for at least three reasons
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