16 research outputs found
Cold storage of platelets in platelet additive solution: an in vitro comparison of two Food and Drug Administration–approved collection and storage systems
Effect of Extreme Wettability on Platelet Adhesion on Metallic Implants: From Superhydrophilicity to Superhydrophobicity
In order to design
antithrombotic implants, the effect of extreme wettability (superhydrophilicity
to superhydrophobicity) on the biocompatibility of the metallic substrates
(stainless steel and titanium) was investigated. The wettability of
the surface was altered by chemical treatments and laser ablation
methods. The chemical treatments generated different functionality
groups and chemical composition as evident from XPS analysis. The
micro/nanopatterning by laser ablation resulted in three different
pattern geometry and different surface roughness and consequently
wettability. The patterned surface were further modified with chemical
treatments to generate a wide range of surface wettability. The influence
of chemical functional groups, pattern geometry, and surface wettability
on protein adsorption and platelet adhesion was studied. On chemically
treated flat surfaces, the type of hydrophilic treatment was shown
to be a contributing factor that determines the platelet adhesion,
since the hydrophilic oxidized substrates exhibit less platelet adhesion
in comparison to the control untreated or acid treated surfaces. Also,
the surface morphology, surface roughness, and superhydrophobic character
of the surfaces are contributing factors to platelet adhesion on the
surface. Our results show that superhydrophobic cauliflower-like patterns
are highly resistant to platelet adhesion possibly due to the stability
of Cassie–Baxter state for this pattern compared to others.
Our results also show that simple surface treatments on metals offer
a novel way to improve the hemocompatibility of metallic substrates