Novel 4(3H)-Quinazolinone analogs: Synthesis and Anticonvulsant Activity

A new series of quinazoline analogs was designed, synthesized, and evaluated for their anticonvulsant activity. Compounds 6, 12, 21, 36, 37,and38 showed 70–100 % protection against PTZ-induced seizures acting as GABA receptor agonists. Compound N- 3,4,5,6-tetrachlorophthalimido)-2-[(3-phenyl-4-oxo-6-methyl-3H-quinazolin2-yl)-thio] acetamide (12) representing the moderate active compounds and 2-[6-iodo-4-oxo-2-(thiophen-2-yl)-quinazolin-3(4H)-yl]-isoindoline-1,3-dione (38) representing the remarkably active compounds in this stud, showed ED A values of 457 and 251 mg/kg; TD values of 562 and 447 mg/kg; PI alues of 1.22 and 1.78, LD 50 values of 1,288 and 1,380 mg/kg, and TI values of 2.82 and 5.50, respectively. Compound 38 roved to be almost twofold more active than the standard drug sodium valproate