Microwave and millimeter-wave power generation in silicon carbide (SiC) IMPATT devices

There are two points that should be noted. First, in the thermal resistance calculations it is assumed that the device is operating at 773 K while the results of the room temperature simulations are used. This was done because there is not enough information to correctly predict the material parameters at 773 K. Since, in general, device performance degrades with increasing temperature, the cw results are perhaps a bit optimistic. Second, the electric field in these structures gets extremely high and there might be some possibility of tunneling. This was not incorporated into the simulation. Again, this could result in different device operating conditions

Role of the cooling rate in the stability of the superconducting phase of (TMTSF)_2ClO_4

The noncentrosymmetric ClO$_4$ anions of the organic superconductor (TMTSF)$_2$ClO$_4$ order below 24K. The size of domains where the anions are ordered is substantially dependent on the cooling rate which is a key parameter for the stability of the low temperature electronic ground states. We study the effect of the cooling rate on the SC phase within a self consistent approach in the framework of the time dependent Ginzburg-Landau theory taking into account the superconducting fluctuations. We derive the superconducting transition temperature which is found to decrease with increasing cooling rate in agreement with recent experimental data.Comment: 5 pages including one figure. Published online in Europhysics Letter

Microwave device investigations Semiannual progress report, 1 Oct. 1969 - 1 Apr. 1970

Beam-plasma interactions, cyclotron harmonic instability study, and millimeter and submillimeter wave detection by paramagnetic material

Microwave device investigations Semiannual progress report, 1 Apr. - 1 Oct. 1969

Summaries of progress in beam plasma interactions, paramagnetic and bulk semiconductor materials, and avalanche diode

Microwave device investigations Semiannual progress report, 1 Oct. 1968 - 1 Apr. 1969

Beam plasma amplification, harmonic generation, and coupling scheme

Switching speeds in double‐barrier resonant‐tunneling diode structures

Switching speeds are calculated for GaAs‐AlGaAs resonant‐tunneling diode structures with different barrier widths from the time‐dependent Schrödinger equation. The speed is determined by monitoring the device current as the bias voltage is instantaneously switched. Effective mass discontinuities at the barrier and quantum well edges are included. Comparisons with previously published results using the wave packet approach are given. It is found that the turn‐off transient is dominated by the lifetime of the quasibound state; however, care must be used in calculating the lifetime.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/70991/2/JAPIAU-70-12-7638-1.pd

Clinical trial data of anti-PD-1/PD-L1 therapy for recurrent or metastatic nasopharyngeal carcinoma: A review

IMPORTANCE: Anti-programmed cell death receptor-1 (PD-1) therapy is standard of care for incurable recurrent or metastatic non-nasopharyngeal head and neck cancer. In contrast, there are no regulatory agency-approved anti-PD-1 agents indicated for the treatment of recurrent or metastatic nasopharyngeal carcinomas (RM-NPC) in the Western hemisphere, and no standard treatment option exists beyond first-line chemotherapy for RM-NPC. The pace of development of novel systemic therapy regimens for RM-NPC has been slow compared to many other advanced tumor types, leaving an unmet clinical need for these patients with a poor prognosis. OBSERVATIONS: Recent clinical trials have documented the clinical activity of anti-PD-1 therapy in RM-NPC. In particular, randomized clinical trials in the first-line setting have demonstrated significant improvements in progression-free survival (PFS) with the addition of anti-PD-1 therapy to standard chemotherapy. Whether the observed PFS benefits require combination chemoimmunotherapy or can be achieved with chemotherapy followed by crossover to immunotherapy upon progression remains unknown. Ongoing clinical trials are exploring novel anti-PD-1 therapy-based combinations, which may further solidify a role for these agents in RM-NPC. CONCLUSIONS AND RELEVANCE: Among patients with RM-NPC, anti-PD-1 therapy added to first-line standard-of-care gemcitabine plus cisplatin provides significantly better efficacy outcomes compared to chemotherapy alone, and anti-PD-1 monotherapy appears to have comparable clinical activity and better tolerability than chemotherapy in previously treated disease. Thus, anti-PD-1 therapy is poised to advance standard of care for the treatment of RM-NPC

Microwave device investigations Semiannual progress report, 1 Apr. - 1 Oct. 1968

Beam-plasma interactions, cyclotron harmonic instabilities, harmonic generation in beam-plasma system, relativistic electron beam studies, and materials test

Frequency multiplication in high-energy electron beams Semiannual progress report, 1 Oct. 1967 - 31 Mar. 1968

Electron beam-plasma interactions, cyclotron harmonic instabilities, paramagnetic and semiconductor materials, and harmonic current generatio