Rats overexpressing the dopamine transporter display behavioral and neurobiological abnormalities with relevance to repetitive disorders

The dopamine transporter (DAT) plays a pivotal role in maintaining optimal dopamine signaling. DAT-overactivity has been linked to various neuropsychiatric disorders yet so far the direct pathological consequences of it has not been fully assessed. We here generated a transgenic rat model that via pronuclear microinjection overexpresses the DAT gene. Our results demonstrate that DAT-overexpression induces multiple neurobiological effects that exceeded the expected alterations in the corticostriatal dopamine system. Furthermore, transgenic rats specifically exhibited behavioral and pharmaco-therapeutic profiles phenotypic of repetitive disorders. Together our findings suggest that the DAT rat model will constitute a valuable tool for further investigations into the pathological influence of DAT overexpression on neural systems relevant to neuropsychiatric disorders

Elementary theory of economic behavior

ix, 332 p.; 23 cm

Hirschbruch family collection 1892-1996

This collection consists primarily of documents pertaining to the genealogy research of Josef Hadar, as well as personal documents of his parents Elsa Graetz and Ludwig Hirschbruch.Ludwig Hirschbruch was born in 1891 in Potsdam, Germany. Elsa Graetz was born in 1891 in Berlin, Germany, the daughter of Jenny Pulvermacher and Isaac Graetz. Elsa and Ludwig Hirschbruch married in Potsdam in 1918 and had three children: Hermann, born in 1918 (he died one year later); Eva Johanna, born in 1920; and Josef, born in 1923. The family emigrated to Palestine in 1933 (?).Lesser Hirschbruch, the father of Ludwig Hirschbruch, was born in 1859 in Czersk (then part of Prussia, today in Poland) and married to Rosa Grant, who was born in Bischofsburg , East Prussia. Lesser Hirschbruch had a brother Moritz Hirschbruch. Their parents were Falk Hirschbruch and Pauline Margoninska, both from Czersk.Finding aid available onlineProcesseddigitizedDaphne Galili was the daughter of Eva Johanna Hirschbruch and Thomas Raymond Wadeson, a British officer, born in 1918. They met in Egypt while both served in the British Army.Note by donor: Bethlehem in Galilee is a village of about 100 families, some of them residing in the original houses of the German Templers

Stochastic dominance for ranking ventures: Comments and extensions

This paper suggests some extensions to Tilley and Eilon's paper on ranking ventures. Tilley and Eilon consider concave utility functions consisting of two linear segments and this allows all rectangular distributions to be ordered. Such utility functions have a wide scope and allow other distributions to be ordered.