ATLAS TDAQ RoI Builder and the Level 2 Supervisor system

The ATLAS High Level Trigger (HLT) uses information from the hardware based Level 1 Trigger system to guide the retrieval of information from the readout system. The Level 1 Trigger elements (jet, electromagnetic, muon candidate, etc.) determine Regions of Interest (RoIs) that seed further trigger decisions. This paper describes the device - the RoI Builder (RoIB) - that collects these data from the Level 1 Trigger and the Level 2 Supervisors (L2SV) Farm that makes these data available to the HLT. The status of the system design and the results of the tests and integration into ATLAS TDAQ system are presented

The Physiological Function of von Willebrand's Factor Depends on Its Tubular Storage in Endothelial Weibel-Palade Bodies

SummaryWeibel-Palade bodies are the 1–5 μm long rod-shaped storage organelles of endothelial cells. We have investigated the determinants and functional significance of this shape. We find that the folding of the hemostatic protein von Willebrand's factor (VWF) into tubules underpins the rod-like shape of Weibel-Palade bodies. Further, while the propeptide and the N-terminal domains of mature VWF are sufficient to form tubules, their maintenance relies on a pH-dependent interaction between the two. We show that the tubular conformation of VWF is essential for a rapid unfurling of 100 μm long, platelet-catching VWF filaments when exposed to neutral pH after exocytosis in cell culture and in living blood vessels. If tubules are disassembled prior to exocytosis, then short or tangled filaments are released and platelet recruitment is reduced. Thus, a 100-fold compaction of VWF into tubules determines the unique shape of Weibel-Palade bodies and is critical to this protein's hemostatic function

The ATLAS High Level Trigger Region of Interest Builder

This article describes the design, testing and production of the ATLAS Region of Interest Builder (RoIB). This device acts as an interface between the Level 1 trigger and the high level trigger (HLT) farm for the ATLAS LHC detector. It distributes all of the level 1 data for a subset of events to a small number of (16 or less) individual commodity processors. These processors in turn provide this information to the HLT. This allows the HLT to use the level 1 information to narrow data requests to areas of the detector where level 1 has identified interesting objects.Comment: 13 pages, 7 figure

Genome‐wide studies of von Willebrand factor propeptide identify loci contributing to variation in propeptide levels and von Willebrand factor clearance

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/134219/1/jth13401-sup-0001-FigS1-S7.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/134219/2/jth13401.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/134219/3/jth13401_am.pd

Characterization of copy-number variants in a large cohort of patients with von Willebrand disease reveals a relationship between disrupted regions and disease type

BACKGROUND: Genetic analysis for von Willebrand disease (VWD) commonly utilizes DNA sequencing to identify variants in the von Willebrand factor ( OBJECTIVES: This study aimed to characterize CNVs in a large sample of VWF mutation-negative VWD patients. METHODS: To determine the role of CNVs in VWD, a VWF high-resolution comparative genomic hybridization array was custom-designed to avoid multiple sequence variations, repeated sequences, and the RESULTS: Among the 204 patients, 7 unique CNVs were found, with a total of 24 CNVs (12%). Of the 7 unique CNVs, 1 was novel, 1 was found in a VWF database, and 5 were previously reported. All patients with type 1C VWD and a CNV had the same exon 33 and 34 in-frame deletion. Certain clinical variables were also significantly different between those with and without CNVs. CONCLUSION: The in-frame deletion in patients with type 1C VWD exactly matches the D4N module of the D4 domain, a region where mutations and deletions are known to affect clearance. We observed significantly higher VWF-to-ristocetin cofactor levels in patients with type 1C VWD and a CNV than in patients without a CNV, suggesting a relationship between CNVs and the increased clearance observed in patients with type 1C VWD. Glycoprotein IbM activity was significantly lower in patients with type 1 VWD and a CNV than in patients without a CNV, suggesting that platelet binding is more affected by CNVs than single base pair mutations. This work elucidates some of the underlying genetic mechanisms of CNVs in these patients

Head butting sheep: Kink Collisions in the Presence of False Vacua

We investigate numerically kink collisions in a 1+1 dimensional scalar field theory with multiple vacua. The domain wall model we are interested in involves two scalar fields and a potential term built from an asymmetric double well and (double) sine-Gordon potential together with an interaction term. Depending on the initial kink setup and impact velocities, the model allows for a wide range of scattering behaviours. Kinks can repel each other, annihilate, form true or false domain walls and reflect off each other

Radiative decays of decuplet hyperons

We calculate the radiative decay widths of decuplet hyperons in a chiral constituent quark model including electromagnetic exchange currents between quarks. Exchange currents contribute significantly to the E2 transition amplitude, while they largely cancel for the M1 transition amplitude. Strangeness suppression of the radiative hyperon decays is found to be weakened by exchange currents. Differences and similarities between our results and other recent model predictions are discussed.Comment: 11 pages, 1 eps figure, revtex, accepted for publication in Phys. Rev.

Design, Construction and Testing of the Digital Hadron Calorimeter (DHCAL) Electronics

A novel hadron calorimeter is being developed for future lepton colliding beam detectors. The calorimeter is optimized for the application of Particle Flow Algorithms (PFAs) to the measurement of hadronic jets and features a very finely segmented readout with 1 x 1 cm2 cells. The active media of the calorimeter are Resistive Plate Chambers (RPCs) with a digital, i.e. one-bit, readout. To first order the energy of incident particles in this calorimeter is reconstructed as being proportional to the number of pads with a signal over a given threshold. A large-scale prototype calorimeter with approximately 500,000 readout channels has been built and underwent extensive testing in the Fermilab and CERN test beams. This paper reports on the design, construction, and commissioning of the electronic readout system of this prototype calorimeter. The system is based on the DCAL front-end chip and a VME-based back-end